Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Leif Bergsagel, P"'
Autor:
Sayaka Suzuki, Kazuma Komiya, Shogo Tsuda, Miya Yoshino, Tsuneyasu Kaisho, P. Leif Bergsagel, Koji Kawamura, Tetsuya Fukuda, Koji Tokoyoda
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic rol
Externí odkaz:
https://doaj.org/article/cd1dbfd2299c40218accf543c2c70207
Autor:
Francesco Maura, David G. Coffey, Caleb K. Stein, Esteban Braggio, Bachisio Ziccheddu, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, Erin W. Meermeier, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety
Externí odkaz:
https://doaj.org/article/0fb36d4f85d4436b947de3da11cd1f2d
Autor:
Nadine H. Abdallah, Arjun Lakshman, Shaji K. Kumar, Joselle Cook, Moritz Binder, Prashant Kapoor, Angela Dispenzieri, Morie A. Gertz, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, David Dingli, Yi Lin, Taxiarchis Kourelis, Rahma Warsame, Leif Bergsagel, S. Vincent Rajkumar
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract The approach to patients with high-risk smoldering multiple myeloma (SMM) varies among clinicians; while some advocate early intervention, others reserve treatment at progression to multiple myeloma (MM). We aimed to describe the myeloma-def
Externí odkaz:
https://doaj.org/article/0c829e27d7424164a3db5cbae0cc8d91
Autor:
Linda B. Baughn, Erik Jessen, Neeraj Sharma, Hongwei Tang, James B. Smadbeck, Mark D. Long, Kathryn Pearce, Matthew Smith, Surendra Dasari, Zohar Sachs, Michael A. Linden, Joselle Cook, A. Keith Stewart, Marta Chesi, Amit Mitra, P. Leif Bergsagel, Brian Van Ness, Shaji K. Kumar
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic landscape has not been comprehens
Externí odkaz:
https://doaj.org/article/5804789b64654223a5493d1fe1a65ff0
Autor:
Radhika Bansal, Mizba Baksh, Jeremy T. Larsen, Matthew A. Hathcock, David Dingli, A. Keith Stewart, Prashant Kapoor, Taxiarchis Kourelis, Suzanne R. Hayman, Rahma M. Warsame, Rafael Fonseca, P. Leif Bergsagel, Sikander Ailawadhi, Shaji K. Kumar, Yi Lin
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-5 (2023)
Abstract Bone marrow (BM) assessment of minimal residual disease (MRD) is prognostic for survival in multiple myeloma (MM). BM is still hypocellular at month 1 post CAR-T, thus the value of MRD negative (MRDneg) status at this timepoint is unclear. W
Externí odkaz:
https://doaj.org/article/fc98ec2442174aae8ca613b312533fc7
Autor:
Rodrigo Fonseca, Mariano Arribas, Julia E. Wiedmeier-Nutor, Yael N. Kusne, Miguel González Vélez, Heidi E. Kosiorek, Richard (Duke) J. Butterfield, Ilan R. Kirsch, Joseph R. Mikhael, A. Keith Stewart, Craig Reeder, Jeremy Larsen, P. Leif Bergsagel, Rafael Fonseca
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Minimal residual disease (MRD) assays allow response assessment in patients with multiple myeloma (MM), and negativity is associated with improved survival outcomes. The role of highly sensitive next generation sequencing (NGS) MRD in combin
Externí odkaz:
https://doaj.org/article/5c9ef42c664f419abb790369e9116b19
Autor:
Natalie Bezman, Erin W Meermeier, Caleb Stein, Meaghen Sharik, Megan Du, Chang-Xin Shi, Yuan Xiao Zhu, Keith Abayasiriwardana, Timothy Fisher, Bas Baaten, Kristin Bompiani-Myers, P Leif Bergsagel, Marta Chesi
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4fb39234917941daab7d6c48109eec89
Autor:
Melissa Alsina, Madhav Dhodapkar, Jesus Berdeja, Krina Patel, Shambavi Richard, Ravi Vij, Xavier Leleu, Daniel Egan, P. Leif Bergsagel, Reshef Ran, Saad Z Usmani, Anna Truppel-Hartmann, Debashree Basudhar, Ethan Thompson, Xirong Zheng, Xiaobo Zhong, Chiara Greggio, Mihaela Popa Mckiver, Marlene Carrasco Alfonso, David Siegel
Publikováno v:
HemaSphere, Vol 7, p e90596a3 (2023)
Externí odkaz:
https://doaj.org/article/6236526bdbd74b7b92eb7a5ad306efce
Autor:
Marie-France Gagnon, Shulan Tian, Susan Geyer, Neeraj Sharma, Celine M. Vachon, Yael Kusne, P. Leif Bergsagel, A. Keith Stewart, S. Vincent Rajkumar, Shaji Kumar, Sikander Ailawadhi, Linda B. Baughn
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-5 (2022)
Externí odkaz:
https://doaj.org/article/ff5dae072f2d408a8873dff9379bf208
Autor:
Josh N. Vo, Yi-Mi Wu, Jeanmarie Mishler, Sarah Hall, Rahul Mannan, Lisha Wang, Yu Ning, Jin Zhou, Alexander C. Hopkins, James C. Estill, Wallace K. B. Chan, Jennifer Yesil, Xuhong Cao, Arvind Rao, Alexander Tsodikov, Moshe Talpaz, Craig E. Cole, Jing C. Ye, Multiple Myeloma Research Consortium, P. Leif Bergsagel, Daniel Auclair, Hearn Jay Cho, Dan R. Robinson, Arul M. Chinnaiyan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The genetic factors involved in disease progression and drug resistance in multiple myeloma (MM) are varied and complex. Here, genomic and transcriptomic profiling of 511 relapsed and refractory MM patients reveals genetic alterations in several onco
Externí odkaz:
https://doaj.org/article/f655f451b78e4e7097fa8cd313e2e43d