Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leif Benner"'
Publikováno v:
eLife, Vol 13 (2024)
Differentiation of female germline stem cells into a mature oocyte includes the expression of RNAs and proteins that drive early embryonic development in Drosophila. We have little insight into what activates the expression of these maternal factors.
Externí odkaz:
https://doaj.org/article/58cde495e6c94acfa05306c304630d80
Autor:
Chad B. Stein, Pavol Genzor, Sanga Mitra, Alexandra R. Elchert, Jonathan J. Ipsaro, Leif Benner, Sushil Sobti, Yijun Su, Molly Hammell, Leemor Joshua-Tor, Astrid D. Haase
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
PIWI-interacting RNAs (piRNAs) are regulatory RNAs that bind to PIWI proteins to control transposons and maintain genome integrity. Here the authors characterized their binding specificity and reveal the 5′ nucleotide bias of the Drosophila Piwi pr
Externí odkaz:
https://doaj.org/article/58d34676a5714e7abafef2822ed72676
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75713 (2013)
Dietary manipulations are increasingly viewed as possible approaches to treating neurodegenerative diseases. Previous studies suggest that Alzheimer's disease (AD) patients present an energy imbalance with brain hypometabolism and mitochondrial defic
Externí odkaz:
https://doaj.org/article/0159c81a16b84adda7ab0af43ec0ac60
Publikováno v:
microPublication biology. 2022
Balancer chromosomes contain multiple inversions that work to suppress crossing over and prevent recovery of most recombinant chromosomes, allowing for alleles to be kept long-term without selection. These balancers are incredible tools, but some all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::988af870fe8f253b8a3d3fa897c86c58
https://pubmed.ncbi.nlm.nih.gov/36439394
https://pubmed.ncbi.nlm.nih.gov/36439394
Tudor domain-containing proteins are conserved across the animal kingdom for their function in germline development and fertility. Previously, we demonstrated thatTudor domain-containing protein 5-like (Tdrd5l)plays an important role in the germline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ce19bf8772451a3d46c394a6712bd58
https://doi.org/10.1101/2022.08.02.502436
https://doi.org/10.1101/2022.08.02.502436
Autor:
Kevin R. Cook, Leif Benner, Dorothy A. Lerit, Brian Oliver, Cale Whitworth, Koen J. T. Venken, Haiwang Yang, Junnan Fang, Elias A Castro
Publikováno v:
Genetics
The small ovary (sov) locus was identified in a female sterile screen, yet its molecular identity and function remained a mystery for decades. In the present work, Benner et al. molecularly map...
Heterochromatin-mediated repression is essential
Heterochromatin-mediated repression is essential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2391895aaca609460372aaa6fc2d6c43
https://doi.org/10.1534/genetics.119.302590
https://doi.org/10.1534/genetics.119.302590
Autor:
Qingcai Meng, Daniel Stoyko, Celine Marlin Andrews, Parthena Konstantinidou, Pavol Genzor, Timothy O, Alexandra R Elchert, Leif Benner, Sushil Sobti, Esther Y Katz, Astrid D Haase
Publikováno v:
Nucleic Acids Res
The combination of genome-editing and epitope tagging provides a powerful strategy to study proteins with high affinity and specificity while preserving their physiological expression patterns. However, stably modifying endogenous genes in cells that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d023c51415f694e22fc4c13a2de72a
https://doi.org/10.1093/nar/gkac448
https://doi.org/10.1093/nar/gkac448
Autor:
Leif Benner, Dorothy A. Lerit, Brian Oliver, Haiwang Yang, Kevin R. Cook, Cale Whitworth, Elias A Castro, Koen J. T. Venken
Repression is essential for coordinated cell type-specific gene regulation and controlling the expression of transposons. In theDrosophilaovary, stem cell regeneration and differentiation requires controlled gene expression, with derepression leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d076d7178e5fadc09d2ed1fbd8a71ba9
Primordial germ cells (PGCs) are the embryonic precursors of the totipotent germline stem cells that form the eggs and sperm required for sexual reproduction. Proper PGC specification, development, and sexual identity are fundamental for fertility an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29b6431923a48d648ac39bcc1f93c658
https://doi.org/10.1016/b978-0-12-809633-8.20549-9
https://doi.org/10.1016/b978-0-12-809633-8.20549-9
Autor:
John F. Morris, Samir El-Andaloussi, Mark A. Behlke, Aurélie Goyenvalle, Matthew J.A. Wood, Graham McClorey, Yoshitsugu Aoki, Amer F. Saleh, Leif Benner, Joel Z. Nordin, Anna M.L. Coenen-Stass, Liz O'Donovan, Christian J. Leumann, Taavi Lehto, Antonio Garcia-Guerra, Siamon Gordon, Michael J. Gait, Kariem Ezzat, Taeyoung Koo, Branislav Dugovic
Publikováno v:
Ahmed, Kariem; Aoki, Yoshitsugu; Koo, Taeyoung; McClorey, Graham; Benner, Leif; Coenen-Stass, Anna; O'Donovan, Liz; Lehto, Taavi; Garciaguerra, Antonio; Nordin, Joel Zacharias; Saleh, Amer F.; Behlke, Mark A.; Morris, John; Goyenvalle, Aurelie; Dugovic, Branislav; Leumann, Christian Joerg; Gordon, Siamon; Gait, Michael J.; El-Andaloussi, Samir and Wood, Matthew J. A. (2015). Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides. Nano letters, 15(7), pp. 4364-4374. American Chemical Society 10.1021/acs.nanolett.5b00490
Antisense oligonucleotides (ASOs) have the potential to revolutionize medicine due to their ability to manipulate gene function for therapeutic purposes. ASOs are chemically modified and/or incorporated within nanoparticles to enhance their stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f63c829ff79f84d4fe2029f153b043b
https://pubmed.ncbi.nlm.nih.gov/26042553
https://pubmed.ncbi.nlm.nih.gov/26042553