Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Leif Antonschmidt"'
Autor:
Benedikt Frieg, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot, Loren B. Andreas, Stefan Becker, Christian Griesinger, Gunnar F. Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Interactions between α-synuclein fibrils and lipids have been associated with the development of Parkinson’s disease. This cryo-EM study reveals structural details of these interactions and suggests a mechanism for fibril-induced lipid extraction.
Externí odkaz:
https://doaj.org/article/370fbaf8c903466ab28670a017457f67
Autor:
Leif Antonschmidt, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky, Vrinda Sant, Sergey Ryazanov, Armin Giese, Gunnar F. Schröder, Stefan Becker, Bert L. de Groot, Christian Griesinger, Loren B. Andreas
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Understanding how small molecules bind to pathological aggregates is of importance for therapeutic and diagnostic development in diseases such as Parkinson’s Disease. Here, the authors reveal a binding site of anle138b to lipid-induced α-synuclein
Externí odkaz:
https://doaj.org/article/ed3eab20b6124a5585faf679ec466929
Autor:
Rıza Dervişoğlu, Leif Antonschmidt, Evgeny Nimerovsky, Vrinda Sant, Myeongkyu Kim, Sergey Ryazanov, Andrei Leonov, Juan Carlos Fuentes-Monteverde, Melanie Wegstroth, Karin Giller, Guinevere Mathies, Armin Giese, Stefan Becker, Christian Griesinger, Loren B. Andreas
Publikováno v:
Methods
Small molecules that bind to oligomeric protein species such as membrane proteins and fibrils are of clinical interest for development of therapeutics and diagnostics. Definition of the binding site at atomic resolution via NMR is often challenging d
Autor:
Benedikt Frieg, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot, Loren B. Andreas, Stefan Becker, Christian Griesinger, Gunnar F. Schröder
Publikováno v:
Nature Communications
Nature Communications 13(1), 6810 (2022). doi:10.1038/s41467-022-34552-7
Nature Communications 13(1), 6810 (2022). doi:10.1038/s41467-022-34552-7
α-synuclein misfolding and aggregation into fibrils is a common feature of α-synucleinopathies, such as Parkinson’s disease, in which α-synuclein fibrils are a characteristic hallmark of neuronal inclusions called Lewy bodies. Studies on the com
Autor:
Vrinda Sant, Dietmar Riedel, Leif Antonschmidt, Christian Griesinger, Stefan Becker, Ingo Mey, Riza Dervisoglu, Kumar Tekwani Movellan, Loren B. Andreas, Claudia Steinem
Publikováno v:
Science Advances
Aggregation intermediates of Parkinson’s disease–related α-synuclein on liposomes are structurally characterized by NMR.
Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structure
Recent advances in the structural biology of disease-relevant α-synuclein fibrils have revealed a variety of structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8250ade122a14bd6919bc33c09dd2f
https://hdl.handle.net/21.11116/0000-0009-689A-521.11116/0000-0009-689E-1
https://hdl.handle.net/21.11116/0000-0009-689A-521.11116/0000-0009-689E-1
Autor:
Abhijith G. Karkisaval, Yushuang Liu, Zi Chao Shiah, Alan T. Johnson, Chunhai Fan, Ratnesh Lal, Deependra Kumar Ban, Leif Antonschmidt, Jinglei Ping, Michael T. Hwang, Gennadi V. Glinsky, Joon Lee, Zejun Wang
Publikováno v:
Advanced materials (Deerfield Beach, Fla.), vol 30, iss 34
Advanced Materials
Advanced Materials
Electronic DNA-biosensor with a single nucleotide resolution capability is highly desirable for personalized medicine. However, existing DNA-biosensors, especially single nucleotide polymorphism (SNP) detection systems, have poor sensitivity and spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdfd958c6ec5b94627468b5e0fd34b3
https://escholarship.org/uc/item/4nr1s7b2
https://escholarship.org/uc/item/4nr1s7b2
Autor:
Sergey Ryazanov, Andre Fischer, Riza Dervisoglu, Gregor Eichele, Andrei Leonov, Christian Griesinger, Loren B. Andreas, Karin Giller, Leif Antonschmidt, Armin Giese, Stefan Becker, Melanie Wegstroth, Roland Benz
Publikováno v:
Biophysical Journal. 116:352a
Autor:
Stefan Becker, Melanie Wegstroth, Armin Giese, Sergey Ryazanov, Loren B. Andreas, Andre Fischer, Riza Dervisoglu, Ratneshwar Lal, Andrei Leonov, Joon Lee, Christian Griesinger, Karin Giller, Leif Antonschmidt, Gregor Eichele
Publikováno v:
Biophysical Journal. 114:560a