Zobrazeno 1 - 10
of 655
pro vyhledávání: '"Leif A, Eriksson"'
Autor:
Vibhu Jha, Leif A. Eriksson
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract The mitochondrial enzyme methylenetetrahydrofolate dehydrogenase (MTHFD2) is involved in purine and thymidine synthesis via 1C metabolism. MTHFD2 is exclusively overexpressed in cancer cells but absent in most healthy adult human tissues. Ho
Externí odkaz:
https://doaj.org/article/c7b319449a7e40df8795f0d51351fc2e
Autor:
Sunniva Sigurdardóttir, Suélen Fernandes Silva, Ievgeniia Tiukova, Hanna Alalam, Ross D. King, Morten Grøtli, Leif A. Eriksson, Per Sunnerhagen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 10 (2024)
ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus continues to cause severe disease and deaths in many parts of the world, despite massive vaccination efforts. Antiviral drugs to curb an ongoing infection remain a priori
Externí odkaz:
https://doaj.org/article/78eed8274ce84aa2812953c0557ee2e6
Autor:
S. Jalil Mahdizadeh, Johan Grandén, Diana Pelizzari-Raymundo, Xavier Guillory, Antonio Carlesso, Eric Chevet, Leif A. Eriksson
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The flavonoid Quercetin (Qe) was identified as an activator of Inositol-requiring enzyme 1 (IRE1) in S. cerevisiae (scIre1p), but its impact on human IRE1 (hIRE1) remains controversial due to the absence of a conserved Qe binding site. We ha
Externí odkaz:
https://doaj.org/article/987ce2cf50b941f4876954d45013c533
Publikováno v:
IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, Vol 16, Pp 7393-7402 (2023)
In this article, we investigate the feasibility to align synthetic aperture radar (SAR) imagery based on a compensation for sea ice drift occurring between temporally shifted image acquisitions. The image alignment is a requirement for improving sea
Externí odkaz:
https://doaj.org/article/d990ecf804354dd09cc4cd06cec3292e
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is growing rapidly among the elderly population around the world. Studies show that a lack of acetylcholine and butyrylcholine due to the overexpression of enzymes A
Externí odkaz:
https://doaj.org/article/9ae550e4d4da46e9b2c90c50eb45c7b9
Publikováno v:
ChemistryOpen, Vol 12, Iss 5, Pp n/a-n/a (2023)
Abstract Methylenetetrahydrofolate dehydrogenase (MTHFD2) is a mitochondrial enzyme involved in 1 C metabolism that is upregulated in various cancer cells, but absent in normal proliferating cells. Xanthine derivatives are the first selective inhibit
Externí odkaz:
https://doaj.org/article/4ae40db2b0194b2b96b24ef13911f906
Autor:
Diana Pelizzari-Raymundo, Dimitrios Doultsinos, Raphael Pineau, Chloé Sauzay, Thodoris Koutsandreas, Timothy Langlais, Antonio Carlesso, Elena Gkotsi, Luc Negroni, Tony Avril, Aristotelis Chatziioannou, Eric Chevet, Leif A. Eriksson, Xavier Guillory
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106687- (2023)
Summary: Inositol-requiring enzyme 1 (IRE1) is a major mediator of the unfolded protein response (UPR), which is activated upon endoplasmic reticulum (ER) stress. Tumor cells experience ER stress due to adverse microenvironmental cues, a stress overc
Externí odkaz:
https://doaj.org/article/ec4db961d77f43c39ac1a07754c5bca7
Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response
Autor:
Kosala N. Amarasinghe, Diana Pelizzari-Raymundo, Antonio Carlesso, Eric Chevet, Leif A. Eriksson, Sayyed Jalil Mahdizadeh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1584-1592 (2022)
The unfolded protein response (UPR) is activated to cope with an accumulation of improperly folded proteins in the Endoplasmic reticulum (ER). The Inositol requiring enzyme 1α (IRE1α) is the most evolutionary conserved transducer of the UPR. Activa
Externí odkaz:
https://doaj.org/article/9c0a764ffe7b4efaad7c3bc6b85214d1
Autor:
Jeroen M. Maertens, Simone Scrima, Matteo Lambrughi, Samuel Genheden, Cecilia Trivellin, Leif A. Eriksson, Elena Papaleo, Lisbeth Olsson, Maurizio Bettiga
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract The use of lignocellulosic-based fermentation media will be a necessary part of the transition to a circular bio-economy. These media contain many inhibitors to microbial growth, including acetic acid. Under industrially relevant conditions,
Externí odkaz:
https://doaj.org/article/eb4202100acf44439af78cf73782172f
Publikováno v:
ACS Omega, Vol 6, Iss 35, Pp 22551-22558 (2021)
Externí odkaz:
https://doaj.org/article/975753a81cc946b5aa4e796344296ae5