Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leiah M. Carey"'
Autor:
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough
Publikováno v:
IUCrJ, Vol 9, Iss 5, Pp 610-624 (2022)
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that are h
Externí odkaz:
https://doaj.org/article/288bb78b21864584a71fa98e261fa74e
Autor:
Brandon M. Murphy, Elizabeth M. Terrell, Venkat R. Chirasani, Tirzah J. Weiss, Rachel E. Lew, Andrea M. Holderbaum, Aastha Dhakal, Valentina Posada, Marie Fort, Michael S. Bodnar, Leiah M. Carey, Min Chen, Craig J. Burd, Vincenzo Coppola, Deborah K. Morrison, Sharon L. Campbell, Christin E. Burd
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The factors that determine the distinct profiles of NRAS mutants across different tumor types remain unclear. Here, the authors use an allelic series of conditional mouse models to investigate the molecular mechanisms underlying the enrichment of spe
Externí odkaz:
https://doaj.org/article/a16f75dc242345688e57e18ad40b740a
Autor:
Minh V, Huynh, G Aaron, Hobbs, Antje, Schaefer, Mariaelena, Pierobon, Leiah M, Carey, J Nathaniel, Diehl, Jonathan M, DeLiberty, Ryan D, Thurman, Adelaide R, Cooke, Craig M, Goodwin, Joshua H, Cook, Lin, Lin, Andrew M, Waters, Naim U, Rashid, Emanuel F, Petricoin, Sharon L, Campbell, Kevin M, Haigis, Diane M, Simeone, Costas A, Lyssiotis, Adrienne D, Cox, Channing J, Der
Publikováno v:
Sci Signal
Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh
Autor:
Minh V. Huynh, G. Aaron Hobbs, Antje Schaefer, Mariaelena Pierobon, Leiah M. Carey, J. Nathaniel Diehl, Jonathan M. DeLiberty, Ryan D. Thurman, Adelaide R. Cooke, Craig M. Goodwin, Joshua H. Cook, Lin Lin, Andrew M. Waters, Naim U. Rashid, Emanuel F. Petricoin, Sharon L. Campbell, Kevin M. Haigis, Diane M. Simeone, Costas A. Lyssiotis, Adrienne D. Cox, Channing J. Der
Publikováno v:
Science Signaling. 15
Missense mutations at the three hotspots in the guanosine triphosphatase (GTPase) RAS—Gly 12 , Gly 13 , and Gln 61 (commonly known as G12, G13, and Q61, respectively)—occur differentially among the three RAS isoforms. Q61 mutations in KRAS are in
Publikováno v:
Journal of inorganic biochemistry. 236
The multifunctional catalytic globin dehaloperoxidase (DHP) from the marine worm Amphitrite ornata was shown to catalyze the H
Autor:
Nicholas G. Martinez, Samantha K. Kistler, Juhi A. Rasquinha, Brian Kuhlman, Sharon L. Campbell, David F Thieker, Leiah M. Carey
Publikováno v:
J Mol Biol
Phosphatidylinositol-3-kinases (PI3Ks) are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate to generate a key lipid second messenger, phosphatidylinositol 3,4,5-bisphosphate. PI3Kα and PI3Kγ require activation by RAS proteins
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1866:230-241
The coelomic hemoglobin of Amphitrite ornata, termed dehaloperoxidase (DHP), is the first known multifunctional catalytic globin to possess biologically-relevant peroxidase and peroxygenase activities. Although the two isoenzymes of DHP, A and B, dif
Publikováno v:
Biochemistry. 55:2465-2478
The marine hemoglobin dehaloperoxidase (DHP) from Amphitrite ornata was found to catalyze the H2O2-dependent oxidation of nitrophenols, an unprecedented nonmicrobial degradation pathway for nitrophenols by a hemoglobin. Using 4-nitrophenol (4-NP) as
Publikováno v:
Molecular Cancer Research. 18:IA04-IA04
RAS is the most frequently activated oncoprotein in human cancer. Mutations in KRAS are prevalent in pancreatic, colon, and lung cancer. Despite the need for anti-RAS therapies, there are no clinically successful targeted therapies for RAS. We will p
Publikováno v:
Biochemistry. 57(30)
The dehaloperoxidase-hemoglobin (DHP) from the terebellid polychaete Amphitrite ornata is a multifunctional hemoprotein that catalyzes the oxidation of a wide variety of substrates, including halo/nitrophenols, haloindoles, and pyrroles, via peroxida