Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Leia M. Smith"'
Autor:
Dennis R. Benjamin, Nancy Whiting, Heather A. Van Epps, Lori Westendorf, Albina Nesterova, Jamie B. Miyamoto, Heather Kostner, Joshua H. Hunter, Steve Duniho, Martha E. Anderson, Leia M. Smith, Django Sussman
In this article, we describe a novel antibody–drug conjugate (ADC; SGN–LIV1A), targeting the zinc transporter LIV-1 (SLC39A6) for the treatment of metastatic breast cancer. LIV-1 was previously known to be expressed by estrogen receptor–positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3042d158186c555911d8bdd687fbbe
https://doi.org/10.1158/1535-7163.c.6537138
https://doi.org/10.1158/1535-7163.c.6537138
Autor:
Dennis R. Benjamin, Nancy Whiting, Heather A. Van Epps, Lori Westendorf, Albina Nesterova, Jamie B. Miyamoto, Heather Kostner, Joshua H. Hunter, Steve Duniho, Martha E. Anderson, Leia M. Smith, Django Sussman
Supplementary Table 1: Surface antigen density impacts in vitro potency of anti-LIV-1 ADC . MCF-7 ATCC cells from three sources with varying levels of LIV-1 expression were tested with SGN-LIV1A for cytotoxicity. Lower antigen density resulted in dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a51b89562749a45548755643dceabbd
https://doi.org/10.1158/1535-7163.22502631.v1
https://doi.org/10.1158/1535-7163.22502631.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplemental data Figure 2 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b0f02df417d29d3cdfdf216f7260c6
https://doi.org/10.1158/1078-0432.22439359.v1
https://doi.org/10.1158/1078-0432.22439359.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplementary Table 1. CD70 and CD27 expression on hematologic tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422ad6c281bb23a2464a5e1982dbaa5f
https://doi.org/10.1158/1078-0432.22439347.v1
https://doi.org/10.1158/1078-0432.22439347.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplemental data Figure 4 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62a8e4e98822cb29c03d0ff7220a2c0
https://doi.org/10.1158/1078-0432.22439353.v1
https://doi.org/10.1158/1078-0432.22439353.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplemental data Figure 3 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c4895dccd1ff616961ea091109f37d
https://doi.org/10.1158/1078-0432.22439356.v1
https://doi.org/10.1158/1078-0432.22439356.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplementary Figures S1-S4 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1149f1efa8dae2589ffaacd68aa0d7ca
https://doi.org/10.1158/1078-0432.22439350.v1
https://doi.org/10.1158/1078-0432.22439350.v1
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Supplemental data Figure 1 from Preclinical Characterization of SGN-70, a Humanized Antibody Directed against CD70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ba638b7c8872f188154eaef3b46b07
https://doi.org/10.1158/1078-0432.22439365
https://doi.org/10.1158/1078-0432.22439365
Autor:
Che-Leung Law, Iqbal S. Grewal, Paul J. Carter, Tamar E. Boursalian, Maureen Ryan, Steven Duniho, Carol A. Morris-Tilden, Kristine A. Gordon, Kerry Klussman, Charlotte F. McDonagh, Leia M. Smith, Julie A. McEarchern
Purpose: CD70 (CD27L) is a member of the tumor necrosis factor family aberrantly expressed on a number of hematologic malignancies and some carcinomas. CD70 expression on malignant cells coupled with its highly restricted expression on normal cells m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd33c4bfb68c2f4becda536245aab4e
https://doi.org/10.1158/1078-0432.c.6516832.v1
https://doi.org/10.1158/1078-0432.c.6516832.v1
Autor:
Steve Duniho, Lori Westendorf, Jamie B. Miyamoto, Dennis Benjamin, Nancy Whiting, Django Sussman, Joshua H. Hunter, Leia M. Smith, Martha Anderson, Albina Nesterova, Heather A. Van Epps, Heather Kostner
Publikováno v:
Molecular Cancer Therapeutics. 13:2991-3000
In this article, we describe a novel antibody–drug conjugate (ADC; SGN–LIV1A), targeting the zinc transporter LIV-1 (SLC39A6) for the treatment of metastatic breast cancer. LIV-1 was previously known to be expressed by estrogen receptor–positiv