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Peroxide Activation for Electrophilic Reactivity by the Binuclear Non-heme Iron Enzyme AurF

Autor: Shinji Kitao, Yeonju Kwak, Martin Srnec, Michael Hu, Shaun D. Wong, J. Martin Bollinger, Kiyoung Park, Lei V. Liu, Caleb B. Bell, Jiyong Zhao, Edward I. Solomon, Makoto Seto, Ning Li, Carsten Krebs, Yoshitaka Yoda

Publikováno v: Journal of the American Chemical Society. 139:7062-7070

Binuclear non-heme iron enzymes activate O2 for diverse chemistries that include oxygenation of organic substrates and hydrogen atom abstraction. This process often involves the formation of peroxo-bridged biferric intermediates, only some of which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cc805ff73ca74a5c70d008d8bd9dde
https://doi.org/10.1021/jacs.7b02997

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Nuclear Resonance Vibrational Spectroscopic Definition of Peroxy Intermediates in Nonheme Iron Sites

Autor: Lei V. Liu, Masayuki Kurokuzu, Lawrence Que, Wonwoo Nam, Makina Saito, Yasuhiro Kobayashi, Yoshitaka Yoda, Yeonju Kwak, Makoto Seto, Edward I. Solomon, Yong Min Lee, Kyle D. Sutherlin

Publikováno v: Journal of the American Chemical Society. 138:14294-14302

FeIII-(hydro)peroxy intermediates have been isolated in two classes of mononuclear non-heme Fe enzymes that are important in bioremediation: the Rieske dioxygenases and the extradiol dioxygenases. The binding mode and protonation state of the peroxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e724499c77e154128327c17171eed6ca
https://doi.org/10.1021/jacs.6b07227

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NRVS Studies of the Peroxide Shunt Intermediate in a Rieske Dioxygenase and Its Relation to the Native FeII O2 Reaction

Autor: Brent S. Rivard, Kiyoung Park, Shinji Kitao, Michael Hu, Jiyong Zhao, Martin Srnec, Makina Saito, Lei V. Liu, Makoto Seto, Melanie S. Rogers, Edward I. Solomon, Yasuhiro Kobayashi, Yoshitaka Yoda, Lars H. Böttger, John D. Lipscomb, Kyle D. Sutherlin

The Rieske dioxygenases are a major subclass of mononuclear nonheme iron enzymes that play an important role in bioremediation. Recently, a high-spin FeIII–(hydro)-peroxy intermediate (BZDOp) has been trapped in the peroxide shunt reaction of benzo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4695a1d11fdb8648cccdad435cde591
https://europepmc.org/articles/PMC5973823/

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Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

Autor: Shinji Kitao, J. Martin Bollinger, Lei V. Liu, E. Ercan Alp, Caleb B. Bell, Yoshitaka Yoda, Jiyong Zhao, Megan L. Matthews, Carsten Krebs, Kiyoung Park, Edward I. Solomon, Makoto Seto, Yeonju Kwak, Martin Srnec, Shaun D. Wong

Publikováno v: Nature. 499:320-323

Mononuclear non-haem iron (NHFe) enzymes catalyse a broad range of oxidative reactions, including halogenation, hydroxylation, ring closure, desaturation and aromatic ring cleavage reactions. They are involved in a number of biological processes, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::599cb5dae0d9861c73a1539a39c12109
https://doi.org/10.1038/nature12304

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Structure and reactivity of a mononuclear non-haem iron(III)–peroxo complex

Autor: Samuel A. Wilson, Eun A. Kang, Lei V. Liu, Keith O. Hodgson, Wonwoo Nam, Mi Hee Lim, Joan Selverstone Valentine, Sujin Jeon, Edward I. Solomon, Joseph J. Braymer, Britt Hedman, Jaeheung Cho

Publikováno v: Nature. 478:502-505

The iron–oxygen species iron(III)-peroxo, iron(III)-hydroperoxo and iron(IV)-oxo are key intermediates often detected in the catalytic cycles of dioxygen activation by haem and non-haem iron enzymes. The high-resolution crystal structure of a monon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fdf9511ee97f62796639c6505779d9
https://doi.org/10.1038/nature10535

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Theoretical Studies of Transition-Metal-Doped Single-Walled Carbon Nanotubes

Autor: Ya Kun Chen, Lei V. Liu, Wei Quan Tian, Yan Alexander Wang

Publikováno v: The Journal of Physical Chemistry C. 115:9306-9311

We have studied single-walled carbon nanotubes (SWCNTs) doped with transition metal (TM) atoms with both exo and endo doping configurations. The electronic and geometric properties of these TM-doped SWCNTs were calculated within density functional th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03eafbf23b2f01a506d014b549022203
https://doi.org/10.1021/jp909490v

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Nuclear Resonance Vibrational Spectroscopy on the FeIVO S=2 Non-Heme Site in TMG3tren: Experimentally Calibrated Insights into Reactivity

Autor: Shaun D. Wong, Jiyong Zhao, Lawrence Que, Caleb B. Bell, E. Ercan Alp, Yeonju Kwak, Jason England, Edward I. Solomon, Lei V. Liu

Publikováno v: Angewandte Chemie. 123:3273-3276

Mononuclear non-heme iron (NHFe) enzymes catalyze a number of key biological reactions including hydroxylation, desaturation, ring closure and halogenation.[1-3] The reactive intermediate that carries out many of the C–H bond activations is an S =

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c532d19c6bf05f0fd4ad7079942b508
https://doi.org/10.1002/ange.201007692

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S K-Edge X-Ray Absorption Spectroscopy and Density Functional Theory Studies of High and Low Spin {FeNO}7 Thiolate Complexes: Exchange Stabilization of Electron Delocalization in {FeNO}7 and {FeO2}8

Autor: Gloria Villar-Acevedo, Britt Hedman, Lei V. Liu, Ning Sun, Julie A. Kovacs, Edward I. Solomon, Marcetta Y. Darensbourg, Keith O. Hodgson, Abhishek Dey

Publikováno v: Inorganic Chemistry. 50:427-436

S K-edge X-ray absorption spectroscopy (XAS) is a direct experimental probe of metal ion electronic structure as the pre-edge energy reflects its oxidation state, and the energy splitting pattern of the pre-edge transitions reflects its spin state. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12aa16d9d1feada4bf1440adc1e5de5d
https://doi.org/10.1021/ic1006378

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Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

Autor: Edward I. Solomon, Jiyong Zhao, Yeonju Kwak, Samuel A. Wilson, Lei V. Liu, Caleb B. Bell, Shaun D. Wong, Keith O. Hodgson, Britt Hedman, Marina S. Chow

Publikováno v: Proceedings of the National Academy of Sciences. 107:22419-22424

Bleomycin (BLM) is a glycopeptide anticancer drug capable of effecting single- and double-strand DNA cleavage. The last detectable intermediate prior to DNA cleavage is a low spin Fe III peroxy level species, termed activated bleomycin (ABLM). DNA st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e47ec4dc1ff23350c8ad1a05752d1e7
https://doi.org/10.1073/pnas.1016323107

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