Zobrazeno 1 - 10
of 6 715
pro vyhledávání: '"Lei L. Chen"'
Autor:
Lei L Chen, Jing Zhu, Jonathan Schumacher, Chongjuan Wei, Latha Ramdas, Victor G Prieto, Arnie Jimenez, Marco A Velasco, Sheryl R Tripp, Robert H I Andtbacka, Launce Gouw, George M Rodgers, Liansheng Zhang, Benjamin K Chan, Pamela B Cassidy, Robert S Benjamin, Sancy A Leachman, Marsha L Frazier
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184154 (2017)
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human
Externí odkaz:
https://doaj.org/article/46dfaee1e3fc43939d5e87e4ff5f3493
Autor:
Launce Gouw, Sancy A. Leachman, Marco A. De Velasco, Jonathan A. Schumacher, Chongjuan Wei, Robert S. Benjamin, Marsha L. Frazier, Victor G. Prieto, George M. Rodgers, Lei L. Chen, Robert H.I. Andtbacka, Latha Ramdas, Benjamin K. Chan, Jing Zhu, Sheryl R. Tripp, Arnie Jimenez, Pamela B. Cassidy, Liansheng Zhang
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184154 (2017)
PLoS ONE, Vol 12, Iss 9, p e0184154 (2017)
We demonstrate that SCF-KIT signaling induces synthesis and secretion of endothelin-3 (ET3) in human umbilical vein endothelial cells and melanoma cells in vitro, gastrointestinal stromal tumors, human sun-exposed skin, and myenteric plexus of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63f12ff2561069c5685a19a6c76bdb6
https://pubmed.ncbi.nlm.nih.gov/28880927
https://pubmed.ncbi.nlm.nih.gov/28880927
Publikováno v:
OncoImmunology. 1:773-776
Imatinib revolutionized gastrointestinal stromal tumor (GIST) treatment but median-progression-free-survival of unresectable/metastatic disease is < 2 y. B-RAFV600-mutated-melanoma responds to vemurafenib dramatically but median-progression-free-surv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::841b28e53f39ee08d9d1dd735db9f2ea
https://doi.org/10.4161/onci.19729
https://doi.org/10.4161/onci.19729
Autor:
A. K. Raymond, Jonathan C. Trent, Kelly K. Hunt, Lei L. Chen, John H. Ward, Kimberly A. Jones, Joseph A. Holden, Marsha L. Frazier, R. Lor Randall, Robert H.I. Andtbacka, Courtney L. Scaife, Haesun Choi, Jing Zhu, Wei Zhang, Elsie F. Wu, Robert S. Benjamin, Victor G. Prieto
Publikováno v:
Modern Pathology. 21:826-836
Activating mutation in KIT or platelet-derived growth factor-alpha can lead to gastrointestinal stromal tumors (GISTs). Eighty-four cases from two institutes were analyzed. Of them, 62 (74%) harbored KIT mutations, 7 of which are previously unreporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f3413b50b5223df4be54f2f60e906d
https://doi.org/10.1038/modpathol.2008.46
https://doi.org/10.1038/modpathol.2008.46
Autor:
Chuslip Charnsangavej, Robert S. Benjamin, Michael A. Burgess, Lei L. Chen, Haesun Choi, Silvana de Castro Faria, Donald A. Podoloff, Homer A. Macapinlac, Shreyaskumar Patel
Publikováno v:
Journal of Clinical Oncology. 25:1753-1759
Purpose Response Evaluation Criteria in Solid Tumors (RECIST) are insensitive in evaluating gastrointestinal stromal tumors (GISTs) treated with imatinib. This study evaluates whether computed tomography (CT) findings of GIST after imatinib treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb1969acbeb5d4759468c1c44a484c5
https://doi.org/10.1200/jco.2006.07.3049
https://doi.org/10.1200/jco.2006.07.3049
Autor:
Shreyaskumar Patel, Peter W.T. Pisters, Janice N. Cormier, Lei L. Chen, Raphael E. Pollock, Robert S. Benjamin, Yan Xing, Stephan A. Vorburger, Matthew T. Ballo, Kelly K. Hunt, Gregory E. Lakin, Michael A. Burgess, Jonathan C. Trent, Barry W. Feig
Publikováno v:
Cancer. 104:2682-2688
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62e15adb4ad78302e057c7780de7cced
https://doi.org/10.1002/cncr.21531
https://doi.org/10.1002/cncr.21531
Autor:
Jonathan C. Trent, Kimberly Hayes, A. K. Raymond, Victor G. Prieto, Marco A. De Velasco, Shreyaskumar Patel, Elsie F. Wu, Robert S. Benjamin, Michael A. Burgess, Marsha L. Frazier, Walter N. Hittelman, Barry W. Feig, Caroline O. Oyedeji, Lei L. Chen, Wei Zhang, Raphael E. Pollock, Homer A. Macapinlac, Kelly K. Hunt, Gregory N. Fuller, Haesun Choi, Latha Ramdas
Publikováno v:
Cancer Research. 64:5913-5919
KIT gain of function mutations play an important role in the pathogenesis of gastrointestinal stromal tumors (GISTs). Imatinib is a selective tyrosine kinase inhibitor of ABL, platelet-derived growth factor receptor (PDGFR), and KIT and represents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c303dd7f8b1b9da2874fbc553d78b0
https://doi.org/10.1158/0008-5472.can-04-0085
https://doi.org/10.1158/0008-5472.can-04-0085
Autor:
Shreyaskumar R. Patel, Michael A. Burgess, Nicholas Papadopolous, Robert S. Benjamin, R N Jennifer Beach, Lei L. Chen, Jonathan C. Trent
Publikováno v:
Cancer. 98:2693-2699
BACKGROUND. The authors conducted a two-arm Phase II study of temozolomide to determine its efficacy and toxicity in patients with soft tissue sarcomas (STSs) who had received, had refused, or were not eligible for standard chemotherapy with doxorubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f57442e9ed7b13e284a19baf7623b5b
https://doi.org/10.1002/cncr.11875
https://doi.org/10.1002/cncr.11875
Autor:
A. Kevin Raymond, Kelly K. Hunt, Robert S. Benjamin, Janice N. Cormier, Courtney L Scaife, Lei L. Chen, Raphael E. Pollock, Peter W.T. Pisters, Barry W. Feig, Shreyaskumar Patel, Michael A. Burgess, Jonathan C. Trent
Publikováno v:
The American Journal of Surgery. 186:665-669
Background Imatinib mesylate (Gleevec) is being studied as adjuvant chemotherapy for the treatment of c KIT + gastrointestinal stromal tumors (GISTs). Early reports using Gleevec for the treatment of unresectable GISTs have shown 50% to 60% partial r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78352043bca3580952b897d6151a6048
https://doi.org/10.1016/j.amjsurg.2003.08.023
https://doi.org/10.1016/j.amjsurg.2003.08.023
Autor:
Thomas Ciesielski, Nelofar Shafi, Lei L. Chen, Nav.T. Singh, Valerie Synnott, Edward.L. Pesanti, Syed Bilgrami
Publikováno v:
Acta Haematologica. 93:101-104
Rare cases of low-grade lymphomas have been described in patients with human immunodeficiency virus (HIV) infection. However, this is the first reported case of mantle-cell lymphoma, a type of low-grade lymphoma, in a patient who also had HIV infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0f135a1ff834aa5e3181c1c3d6df32
https://doi.org/10.1159/000204120
https://doi.org/10.1159/000204120