Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lei K. Zhang"'
Autor:
Ping Zhao, Aleksandra Galetin, Vikram Arya, Lei K. Zhang, Shiew-Mei Huang, Xinning Yang, Daniel Scotcher, Amin Rostami-Hodjegan
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f639df1809d72b03e1d22fcfaf5f03
https://doi.org/10.1016/j.dmpk.2020.04.266
https://doi.org/10.1016/j.dmpk.2020.04.266
Autor:
Lei K. Zhang
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab64d43893eb99768006b89373753231
https://doi.org/10.1016/j.dmpk.2020.04.272
https://doi.org/10.1016/j.dmpk.2020.04.272
Publikováno v:
The AAPS Journal. 16:172-180
Drug interactions due to efflux transporters may result in one drug increasing or decreasing the systemic exposure of a second drug. The potential for in vivo drug interactions is estimated through in vitro cell assays. Variability in in vitro parame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90bd0c7d1baf6dca85da2bad30816846
https://doi.org/10.1208/s12248-013-9554-7
https://doi.org/10.1208/s12248-013-9554-7
Autor:
Shiew-Mei Huang, James E. Polli, Wei Zhang, Qing Li, Lei K. Zhang, Zhongqi Dong, Yan Shu, Dong Guo
Publikováno v:
Toxicology and Applied Pharmacology. 273:100-109
The nephrotoxicity limits the clinical application of cisplatin. Human organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATEs) work in concert in the elimination of cationic drugs such as cisplatin from the kidney. We h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a41e542a9a03e816fe8ef2a7329c9b
https://doi.org/10.1016/j.taap.2013.08.024
https://doi.org/10.1016/j.taap.2013.08.024
Autor:
Laurent Salphati, Eric Sands, Praveen Balimane, Caroline A. Lee, Johan E. Palm, Joe Bentz, Lalitha Podila, Jesse Taur, Tetsuo Yamagata, Lei K. Zhang, Kathleen M. Hillgren, Eric L. Reyner, Marie Brännström, Dietmar Weitz, Emile Plise, Jocelyn Yabut, Masoud Jamei, Harma Ellens, Anne Pak, Dallas Bednarczyk, Guangqing Xiao, Mitchell E. Taub, Libin Li, Heleen M. Wortelboer, Elke S Perloff, Andrew K Mason, Michael P. O'Connor, Krisztina Herédi-Szabó, Aarti Patel, Ganesh Rajaraman, Xiaoyan Chu, Evelyn Hollnack-Pusch, Christoph Funk, Joann Coleman, Cindy Q. Xia, Xuena Lin, Imad Hanna, Ailan Guo, Sibylle Neuhoff
Publikováno v:
Drug Metabolism and Disposition. 41:1347-1366
A P-glycoprotein (P-gp) IC₅₀ working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC₅₀ determinations. Each laboratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d287357bc8fa4a0193383933cbb55d1a
https://doi.org/10.1124/dmd.112.050500
https://doi.org/10.1124/dmd.112.050500
Autor:
Chao Han, Sandhya Girish, Raymond Evers, Shiew-Mei Huang, Steven W. Martin, Hong Zhao, Lewis Klunk, Lei K. Zhang, Eva Gil Berglund, Honghui Zhou, Mark C. Peterson, Min Zhu, Joseph P. Balthasar, Amita Joshi
Publikováno v:
The AAPS Journal
Therapeutic proteins (TPs) are increasingly combined with small molecules and/or with other TPs. However preclinical tools and in vitro test systems for assessing drug interaction potential of TPs such as monoclonal antibodies, cytokines and cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93782684f5e1e495ffd90bacdcf54758
http://europepmc.org/articles/PMC3144367
http://europepmc.org/articles/PMC3144367
Publikováno v:
The AAPS journal. 16(1)
Drug interactions due to efflux transporters may result in one drug increasing or decreasing the systemic exposure of a second drug. The potential for in vivo drug interactions is estimated through in vitro cell assays. Variability in in vitro parame
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::14db550a90d784173d8670cd749161b9
https://pubmed.ncbi.nlm.nih.gov/24338112
https://pubmed.ncbi.nlm.nih.gov/24338112
Autor:
Aarti Patel, Leslie J. Dickmann, J. Greg Slatter, Theresa V. Nguyen, Raymond Evers, Jane R. Kenny, Shannon Dallas, Eugenia Kraynov, Lei K. Zhang, Odette A. Fahmi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 41(9)
Drug-drug interactions (DDIs) between therapeutic proteins (TPs) and small-molecule drugs have recently drawn the attention of regulatory agencies, the pharmaceutical industry, and academia. TP-DDIs are mainly caused by proinflammatory cytokine or cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d819ed1c6be5726d2729b8d2b7d564
https://pubmed.ncbi.nlm.nih.gov/23792813
https://pubmed.ncbi.nlm.nih.gov/23792813