Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Lei, Diao"'
Autor:
Qiao Li, Ying Cheng, Zhongsheng Tong, Yunjiang Liu, Xian Wang, Min Yan, Jianhua Chang, Shusen Wang, Caiwen Du, Liang Li, Chunjiao Wu, Mingxia Wang, Zhuo Wang, Zhuli Wu, Xingli Wang, Yongli Jin, Lei Diao, Yi Sun, Yongjiao Zhang, Ai-Min Hui, Binghe Xu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Currently approved HER2-targeting antibody-drug conjugates (ADCs) for HER2-positive breast cancer (BC) are associated with safety concerns. In this multicenter, single-arm, dose-escalation (phase 1a) and dose-expansion (phase 1b) phase 1 tri
Externí odkaz:
https://doaj.org/article/a970daa7143b4f0c9d62cb86b63129d8
Autor:
Lin Zhao, Yi Sun, Xiaoran Yang, Ling Tian, Lize Li, Fangfang Wang, Xiaoye Niu, Lei Diao, Haiyan Li
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Cardiotoxicity and QT interval prolongation have been a common cause of withdrawal of drugs from the market. FCN-437c is an oral, second-generation, potent, and selective CDK4/6 inhibitor for the treatment of patients with HR+/HER2- metastatic breast
Externí odkaz:
https://doaj.org/article/f2cebee37b224c779304de53b04a4ef2
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
ObjectiveSAF-189s is a potent ALK/ROS1 inhibitor that is currently in clinical development for treating advanced ALK+/ROS1+ non-small cell lung cancer (NSCLC). Comprehensive population pharmacokinetics (PopPK) and exposure–response models were deve
Externí odkaz:
https://doaj.org/article/781117d2f18b49b1ad708847a0666c61
Autor:
Xiaoqing Li, Yunhai Bo, Qingping Zeng, Lei Diao, Stephanie Greene, John Patterson, Lu Liu, Fen Yang
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background: ORIN1001, a first-in-class oral IRE1-α endoribonuclease inhibitor to block the activation of XBP1, is currently in clinical development for inhibiting tumor growth and enhancing the effect of chemical or targeted therapy. Early establish
Externí odkaz:
https://doaj.org/article/f807ce6e694648adacfed803dbdf3074
Autor:
Huiling Qin, Yan Tan, Lei Diao, Ai-Min Hui, Zhuli Wu, Yongchun Zhou, Juan Sun, Xiao Xiang, Jingjun Qiu, Wei Hu
Publikováno v:
Drugs in R&D, Vol 23, Iss 4, Pp 465-473 (2023)
Abstract Background and Objectives This study was conducted to investigate the effect of high-fat meals on the pharmacokinetics (PK) and safety profile of SAF-189s, a novel ALK/ROS1 inhibitor. Methods This was a single-center, phase I, open-label, cr
Externí odkaz:
https://doaj.org/article/a513998392c64eec8b24dd33ea1d2764
Autor:
Kun Wang, Pengqiang Duan, Xusheng Chen, Qing Yang, Guowei Feng, Lei Diao, Zhenting Zhang, Xin Yao
Publikováno v:
Cancer Medicine, Vol 12, Iss 13, Pp 14149-14156 (2023)
Abstract Objective To investigate the efficacy of tyrosine kinase inhibitors (TKIs) in the treatment of metastatic renal cell carcinoma (mRCC) with rhabdoid (mRCC‐R) and sarcomatoid (mRCC‐S) differentiations. Materials and Methods In this single
Externí odkaz:
https://doaj.org/article/6002303fa550471aaaa4142eb9c6712f
Autor:
Xiaojie Hu, Wenbin Li, Kang Zeng, Zhongyuan Xu, Changxing Li, Zhuang Kang, Shenglan Li, Xin Huang, Pu Han, Hongmei Lin, Ai-Min Hui, Yan Tan, Lei Diao, Ben Li, Xingli Wang, Zhuli Wu, Xiaoxi Lin
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Surgery is a common treatment strategy for patients with neurofibromatosis type 1 (NF1)-related plexiform neurofibroma (PN) and has limited efficacy. FCN-159 is a novel anti-tumorigenic drug via selective inhibition of MEK1/2. Thi
Externí odkaz:
https://doaj.org/article/40e19bb09d2a4f40ac6a436eed7cad1e
Autor:
Gang Yuan, Yili Chen, Li Li, Xin Wang, Gang Wei, Jiawei Zeng, Ai-Min Hui, Yueyun Jiang, Han Zhao, Lei Diao, Yongchun Zhou, Yinglian Xiao, Minhu Chen
Publikováno v:
International Journal of Clinical Practice, Vol 2024 (2024)
Background. Tenapanor is a locally acting selective sodium-hydrogen exchanger 3 inhibitor with the potential to treat sodium/phosphorus and fluid overload in various cardiac-renal diseases, which has been approved for constipation-predominant irritab
Externí odkaz:
https://doaj.org/article/d85dbf56ed6043709878e54acef2fe34
Autor:
Caixuan Liu, Mingliang Jin, Shutian Wang, Wenyu Han, Qiaoyu Zhao, Yifan Wang, Cong Xu, Lei Diao, Yue Yin, Chao Peng, Lan Bao, Yanxing Wang, Yao Cong
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract The eukaryotic chaperonin TRiC/CCT assists the folding of about 10% of cytosolic proteins through an ATP-driven conformational cycle, and the essential cytoskeleton protein tubulin is the obligate substrate of TRiC. Here, we present an ensem
Externí odkaz:
https://doaj.org/article/6674e738d7e64afd9e420eda67481fea
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18483- (2023)
In order to investigate the impact of blade tip winglet position on the internal flow and noise characteristics of axial flow fans,three different blade tip winglets,namely the TSW blade, the SSW blade, and the PSW blade,were hereby proposed. The acc
Externí odkaz:
https://doaj.org/article/49f0a79db3ed410ca9e14b4b802dc6a4