Chronic evoked seizures in young pre-symptomatic APP/PS1 mice induce serotonin changes and accelerate onset of Alzheimer’s disease-related neuropathology

Autor: del Pozo, Aaron, Knox, Kevin M., Lehmann, Leanne M., Davidson, Stephanie, Rho, Seongheon Leo, Jayadev, Suman, Barker-Haliski, Melissa

Publikováno v: In Progress in Neurobiology April 2024 235

Risk of unexpected mortality is increased by evoked seizures in the APP/PSEN1, but not PSEN2‐N141I transgenic, mouse model of Alzheimer's disease.

Autor: Sanz, Aaron Del Pozo, Knox, Kevin M, Davidson, Stephanie, Lehmann, Leanne M, Barker‐Haliski, Melissa

Publikováno v: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Dec2022 Supplement 3, Vol. 18 Issue 3, p1-2, 2p

Alzheimer's disease-associated genotypes differentially influence chronic evoked seizure outcomes and antiseizure medicine activity in aged mice.

Autor: Knox KM; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195., Davidson S; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195., Lehmann LM; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195., Skinner E; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195., Lo A; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195., Jayadev S; Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98195., Barker-Haliski M; Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.