EZH2 mutations in follicular lymphoma distort H3K27me3 profiles and alter transcriptional responses to PRC2 inhibition

Autor: Pierre Romero, Laia Richart, Setareh Aflaki, Ambre Petitalot, Megan Burton, Audrey Michaud, Julien Masliah-Planchon, Frédérique Kuhnowski, Samuel Le Cam, Carlos Baliñas-Gavira, Céline Méaudre, Armelle Luscan, Abderaouf Hamza, Patricia Legoix, Anne Vincent-Salomon, Michel Wassef, Daniel Holoch, Raphaël Margueron

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Abstract Mutations in chromatin regulators are widespread in cancer. Among them, the histone H3 lysine 27 methyltransferase Polycomb Repressive Complex 2 (PRC2) shows distinct alterations according to tumor type. This specificity is poorly understood

Externí odkaz: https://doaj.org/article/1b39f7921f8b45b382015dc3a19b069d

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Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling

Autor: L. Orliaguet, T. Ejlalmanesh, A. Humbert, R. Ballaire, M. Diedisheim, J. B. Julla, D. Chokr, J. Cuenco, J. Michieletto, J. Charbit, D. Lindén, J. Boucher, C. Potier, A. Hamimi, S. Lemoine, C. Blugeon, P. Legoix, S. Lameiras, L. G. Baudrin, S. Baulande, A. Soprani, F. A. Castelli, F. Fenaille, J. P. Riveline, E. Dalmas, J. Rieusset, J. F. Gautier, N. Venteclef, F. Alzaid

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Interferon Regulatory Factor 5 levels have been shown to increase in adipose tissue macrophages in diet-induced obesity. Here authors show that IRF5 transcriptionally represses the Growth Hormone Inducible Transmembrane Protein gene encoding a mitoch

Externí odkaz: https://doaj.org/article/3d59f1d6382c436d944d373741f290d3

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Methylation, Gene Expression, and Risk Genotypes at the TERT-CLPTM1L Locus in Cervical Cancer.

Autor: Ramachandran D; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Mao Q; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Liao D; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Kamal M; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France., Schürmann P; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Eisenblätter R; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Geffers R; Genome Analytics, Helmholtz Center for Infection Research, Braunschweig, Germany., Balint B; SeqOmics Biotechnology Ltd., Morahalom, Hungary., Lecompte L; Institut Curie, INSERM U900, Mines Paris Tech, Paris/Saint-Cloud, France., Servant N; Institut Curie, INSERM U900, Mines Paris Tech, Paris/Saint-Cloud, France., Chérif LL; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France., Lamy C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France., Baulande S; Institut Curie, ICGex Next-Generation Sequencing platform, Paris, France., Legoix P; Institut Curie, ICGex Next-Generation Sequencing platform, Paris, France., Le Tourneau C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France.; Institut Curie, INSERM U900, Mines Paris Tech, Paris/Saint-Cloud, France., Latouche A; Institut Curie, INSERM U900, Mines Paris Tech, Paris/Saint-Cloud, France.; Conservatoire National des Arts et Métiers, Paris, France., Hillemanns P; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany., Scholl S; Department of Drug Development and Innovation (D3i), Institut Curie, Paris and Saint-Cloud, France., Dörk T; Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.

Publikováno v: Molecular carcinogenesis [Mol Carcinog] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.