Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Leggy A Arnold"'
Autor:
Sarojini Bulbule, Carl Gunnar Gottschalk, Molly E. Drosen, Daniel Peterson, Leggy A. Arnold, Avik Roy
Publikováno v:
Journal of Central Nervous System Disease, Vol 16 (2024)
Background Tetrahydrobiopterin (BH4) and its oxidized derivative dihydrobiopterin (BH2) were found to be strongly elevated in ME/CFS patients with orthostatic intolerance (ME + OI). Objective However, the molecular mechanism of biopterin biogenesis i
Externí odkaz:
https://doaj.org/article/828c8fd545a94f76940a75ffc854362a
Autor:
Richard G Moore, Thilo S Lange, Katina Robinson, Kyu K Kim, Alper Uzun, Timothy C Horan, Nada Kawar, Naohiro Yano, Sharon R Chu, Quanfu Mao, Laurent Brard, Monique E DePaepe, James F Padbury, Leggy A Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K Singh
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34443 (2012)
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of er
Externí odkaz:
https://doaj.org/article/1ab19dbd7f644ccbadcc68da0d5af459
Autor:
Xingjie Ping, Michelle J. Meyer, Nicolas M. Zahn, Lalit K. Golani, Dishary Sharmin, Kamal P. Pandey, Sepideh Revanian, Prithu Mondal, Xiaoming Jin, Leggy A. Arnold, Rok Cerne, James M. Cook, Branka Divović, Miroslav M. Savić, Arnold Lippa, Jodi L. Smith, Jeffrey M. Witkin
Publikováno v:
Drug Development Research
A series of imidazodiazepines has been developed that possess reduced sedative liabilities but retain efficacy in anticonvulsant screening models. The latest of these compounds, (5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazole[1,5-α][1,4]diazepin
Autor:
Kamal P. Pandey, Branka Divović, Farjana Rashid, Lalit K. Golani, Rok Cerne, Nicolas M. Zahn, Michelle Jean Meyer, Leggy A. Arnold, Dishary Sharmin, Md Yeunus Mian, Jodi L. Smith, Xingjie Ping, Xiaoming Jin, Arnold Lippa, V.V.N. Phani Babu Tiruveedhula, James M. Cook, Miroslav M. Savić, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 385:50-61
Autor:
Jose F, Perez-Zoghbi, Dannah Rae, Sajorda, Daniel A, Webb, Leggy A, Arnold, Charles W, Emala, Gene T, Yocum
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:482-490
Asthma is a common respiratory disease characterized, in part, by excessive airway smooth muscle (ASM) contraction (airway hyperresponsiveness). Various GABA
Autor:
Negar Khazan, Kyu Kwang Kim, Jeanne N. Hansen, Niloy A. Singh, Taylor Moore, Cameron W. A. Snyder, Ravina Pandita, Myla Strawderman, Michiko Fujihara, Yuta Takamura, Ye Jian, Nicholas Battaglia, Naohiro Yano, Yuki Teramoto, Leggy A. Arnold, Russell Hopson, Keshav Kishor, Sneha Nayak, Debasmita Ojha, Ashoke Sharon, John M. Ashton, Jian Wang, Michael T. Milano, Hiroshi Miyamoto, David C. Linehan, Scott A. Gerber, Nada Kawar, Ajay P. Singh, Erdem D. Tabdanov, Nikolay V. Dokholyan, Hiroki Kakuta, Peter W. Jurutka, Nina F. Schor, Rachael B. Rowswell-Turner, Rakesh K. Singh, Richard G. Moore
Publikováno v:
Journal of Medicinal Chemistry. 65:6039-6055
Vitamin-D receptor (VDR) mRNA is overexpressed in neuroblastoma and carcinomas of lung, pancreas, and ovaries and predicts poor prognoses. VDR antagonists may be able to inhibit tumors that overexpress VDR. However, the current antagonists are arduou
Autor:
M. S. Rashid Roni, Nicolas M. Zahn, Gene T. Yocum, Daniel A. Webb, Md Yeunus Mian, Michelle J. Meyer, Anika S. Tylek, James M. Cook, Charles W. Emala, Douglas C. Stafford, Leggy A. Arnold
Publikováno v:
Drug Dev Res
MIDD0301 is being developed as an oral drug to relax airway smooth muscle and reduce lung inflammation in asthma. We report a comparative study of MIDD0301 and its S isomer (MIDD0301S) and found that the compounds have equivalent affinity for GABA(A)
Autor:
Jawad B. Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S. Virdi, David N. Frick, A. F. M. Towheedur Rahman, Joseph S. Ulicki, Sreya Biswas, Leggy A. Arnold, M. S. Rashid Roni, Eric Y. Cheng, Douglas A. Steeber, Karyn M. Frick, M. Mahmun Hossain
Publikováno v:
J Med Chem
Histone acetylation is a prominent epigenetic modification linked to the memory loss symptoms associated with neurodegenerative disease. The use of existing histone deacetylase inhibitor (HDACi) drugs for treatment is precluded by their weak blood–
Autor:
Nicolas M. Zahn, M. S. Rashid Roni, Gene T. Yocum, Michelle J. Meyer, Daniel A. Webb, Md Yeunus Mian, James M. Cook, Douglas C. Stafford, Charles W. Emala, Leggy A. Arnold
Publikováno v:
ACS Pharmacology & Translational Science. 5:80-88
Autor:
Leggy A. Arnold, Nicolas M Zahn, James M. Cook, Daniel A. Webb, Brandon N Mikulsky, Yeunus Mian, Margaret L. Guthrie, M S Rashid Roni, Douglas C. Stafford, Daniel E. Knutson
Publikováno v:
Curr Drug Metab
Background: MIDD0301 is an oral asthma drug candidate that binds GABAA receptors on airway smooth muscle and immune cells. Objective: The objective of this study is to identify and quantify MIDD0301 metabolites in vitro and in vivo and determine the