Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Autor: Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., van Amelsvoort, T., Bartels-Velthuis, A. A., Bruggeman, R., Cahn, W., Guloksuz, S., de Haan, L., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., Alizadeh, B. Z., Luykx, J. J., Rutten, B. P. F., van Winkel, R., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F., Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R., Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A.

Publikováno v: Translational Psychiatry, 12(1):145. Nature Publishing Group
Translational psychiatry, 12(1):145. Nature Publishing Group

Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d35979803fbaf570d9245558fcc0da
https://research.rug.nl/en/publications/68c11f0b-1d30-47b1-b8cc-469ae7b6003c

Evidence that duplications of 22q11.2 protect against schizophrenia

Autor: Richards, A L, Legge, S E, Levinson, D, Kendler, K S, Walters, J T R, Craddock, N, Duan, J, Morris, D, Shi, J, Chambert, K D, Sanders, A, O'Neill, F A, Kirov, G, Genovese, G, Moy, W, Cormican, P, Szatkiewicz, J, Pato, M, Rees, E, Hultman, C, Pato, C, Sklar, P, Jones, I, Green, E K, Gill, M, Moran, J L, Sullivan, P F, Davies, G, Corvin, A, O'Dushlaine, C, Riley, B, Göring, H H H

A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis of 47 005 individuals, the largest CNV a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dacac11ce2aa65f3e26759a6d3cc1f02

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Erratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia

Autor: Legge, S E, Hamshere, M L, Ripke, S, Pardinas, A F, Goldstein, J I, Rees, E, Richards, A L, Leonenko, G, Jorskog, L F, Chambert, K D, Collier, D A, Genovese, G, Giegling, I, Holmans, P, Jonasdottir, A, Kirov, G, McCarroll, S A, MacCabe, J H, Mantripragada, K, Moran, J L, Neale, B M, Stefansson, H, Rujescu, D, Daly, M J, Sullivan, P F, Owen, M J, O'Donovan, M C, Walters, J T R

Publikováno v: Molecular Psychiatry; January 2018, Vol. 23 Issue: 1 p162-163, 2p

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders.

Autor: Okhuijsen-Pfeifer C; Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands.; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands., van der Horst MZ; Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands.; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands.; GGNet Mental Health, Warnsveld, The Netherlands., Bousman CA; Department of Medical Genetics, University of Calgary, Calgary, Canada.; Department of Psychiatry, University of Calgary, Calgary, Canada.; Department of Physiology & Pharmacology, University of Calgary, Calgary, Canada.; Department of Psychiatry, University of Melbourne, Melbourne Neuropsychiatry Centre, Melbourne, Australia., Lin B; Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands.; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands., van Eijk KR; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands., Ripke S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany., Ayhan Y; Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Babaoglu MO; Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Bak M; Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.; Mondriaan, Mental Health Institute, Maastricht, The Netherlands., Alink W; Multicomplexe Zorg, Pro Persona, Wolfheze, The Netherlands., van Beek H; Clinical Recovery Clinic, Mental Health Services Rivierduinen, Leiden, The Netherlands., Beld E; Mental Health Organization North-Holland North location Den Helder, Den Helder, The Netherlands., Bouhuis A; Program for early psychosis & severe mental illness, Pro Persona Mental Healthcare, Wolfheze, The Netherlands., Edlinger M; Department of Psychiatry, Psychotherapy and Psychosomatics, Division for Psychiatry I, Medical University Innsbruck, Innsbruck, Austria., Erdogan IM; Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Ertuğrul A; Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Yoca G; Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey.; Şarkışla State Hospital, Ministry of Health, Sivas, Turkey., Everall IP; Department of Psychiatry, University of Melbourne, Melbourne Neuropsychiatry Centre, Melbourne, Australia.; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Görlitz T; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty University Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Grootens KP; Reinier van Arkel, s-Hertogenbosch, The Netherlands.; Unit for Clinical Psychopharmacology and Neuropsychiatry, Radboud University Medical Centre, Nijmegen, The Netherlands., Gutwinski S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany., Hallikainen T; Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland., Jeger-Land E; Arkin, Institute for Mental Health, Amsterdam, The Netherlands., de Koning M; Arkin, Institute for Mental Health, Amsterdam, The Netherlands.; Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands., Lähteenvuo M; Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland., Legge SE; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom., Leucht S; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Morgenroth C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany., Müderrisoğlu A; Department of Pharmacology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey., Narang A; Department of Medical Genetics, University of Calgary, Calgary, Canada., Pantelis C; Department of Psychiatry, University of Melbourne, Melbourne Neuropsychiatry Centre, Melbourne, Australia., Pardiñas AF; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom., Oviedo-Salcedo T; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Schneider-Thoma J; Department of Psychiatry and Psychotherapy, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Schreiter S; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Berlin, Germany.; Berlin Institute of Health (BIH), BIH Biomedical Innovation Academy, Berlin, Germany., Repo-Tiihonen E; Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland., Tuppurainen H; Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland., Veereschild M; GGNet Mental Health, Warnsveld, The Netherlands., Veerman S; Mental Health Organization North-Holland North location Alkmaar, Alkmaar, The Netherlands., de Vos M; GGNet Mental Health, Warnsveld, The Netherlands., Wagner E; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany., Cohen D; Mental Health Organization North-Holland North location Heerhugowaard, Heerhugowaard, The Netherlands., Bogers JPAM; High Care Clinics, Mental Health Services Rivierduinen, Leiden, The Netherlands., Walters JTR; Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, United Kingdom., Yağcıoğlu AEA; Department of Psychiatry, Faculty of Medicine, Hacettepe University, Ankara, Turkey., Tiihonen J; Department of Forensic Psychiatry, University of Kuopio, Niuvanniemi Hospital, Kuopio, Finland.; Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.; Center for Psychiatric Research, Stockholm City Council, Stockholm, Sweden., Hasan A; Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.; Department of Psychiatry, Psychotherapy and Psychosomatics, Medical Faculty University Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany., Luykx JJ; Department of Psychiatry, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands. j.luykx@umcutrecht.nl.; Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht University, Brain Center, Utrecht, The Netherlands. j.luykx@umcutrecht.nl.; GGNet Mental Health, Warnsveld, The Netherlands. j.luykx@umcutrecht.nl.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2022 Apr 07; Vol. 12 (1), pp. 145. Date of Electronic Publication: 2022 Apr 07.