Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Lefteris C. Zacharia"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/62836552cd654f68b1ec702da957a477
Publikováno v:
Natural Product Research. 36:4210-4214
Smoking is a public health concern, and even though smoking cessation methods exist, nicotine replacement therapy (NRT) is often ineffective. Smoking behavior is related to the nicotine metabolizing enzyme (NME) P450 2A6 (mouse 2A5) polymorphisms. Ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b284a6bade5b8eb529515732eab03f4
https://doi.org/10.1080/14786419.2021.1972419
https://doi.org/10.1080/14786419.2021.1972419
Publikováno v:
Life Sciences. 309:121047
Alzheimer's Disease (AD) is characterized by progressive cognitive impairment, and memory loss. It has been shown that depletion of estrogens renders women vulnerable to AD with menopause women presenting higher risk for AD development than men. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119df7d191a6578b4010da1886f8fc5e
https://doi.org/10.1016/j.lfs.2022.121047
https://doi.org/10.1016/j.lfs.2022.121047
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 703 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Aging-associated neurodegenerative diseases, which are characterized by progressive neuronal death and synapses loss in human brain, are rapidly growing affecting millions of people globally. Alzheimer’s is the most common neurodegenerative disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0963ac293c6583a10fae54bf442dac8
https://www.mdpi.com/1422-0067/21/3/703
https://www.mdpi.com/1422-0067/21/3/703
Autor:
Lefteris C. Zacharia, Kyriacos Ioannou, Constantina Eleftheriou, Mohamed El-Shazly, Kyriaki S. Pafiti, Manos C. Vlasiou
Publikováno v:
Journal of Molecular Structure. 1249:131567
A newly synthesized chalcone derivative was used as a ligand to form a stable cobalt (II/III) complex. The cytotoxic activity of the complex was evaluated against breast cancer cells MDA-MB-231. The prooxidant and DNA binding activity of the complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625fb6e66a0ff32277ad341fffaefd34
https://doi.org/10.1016/j.molstruc.2021.131567
https://doi.org/10.1016/j.molstruc.2021.131567
Autor:
Lefteris C. Zacharia
Publikováno v:
Toxicological Sciences. 159:279-289
This report aims to determine the permitted daily exposure (PDE) of flutamide, an androgen receptor blocker, as directed by guideline EMA/CHMP/CVPM/SWP/169430/2012 that came into effect on June 2015. A literature review was conducted to identify toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c5a84ef27e0769cbc6774a083a1972
https://doi.org/10.1093/toxsci/kfx135
https://doi.org/10.1093/toxsci/kfx135
Autor:
Antreas Afantitis, Lefteris C. Zacharia, Georgia Melagraki, Kalliopi Moschovou, Thomas Mavromoustakos
Publikováno v:
Expert opinion on drug discovery. 15(1)
Introduction: Parkinson's Disease (PD) is a neurodegenerative central nervous system (CNS) disorder characterized by dopaminergic neuron degeneration with consequent reduction in striatal dopamine (DA) levels that leads to motor symptoms. Catechol-O-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07f0dbb80918fb1d20d75660d0661f2
https://pubmed.ncbi.nlm.nih.gov/31744341
https://pubmed.ncbi.nlm.nih.gov/31744341
Autor:
Stylianou, Andreas, Gkretsi, Vasiliki, Louca, Maria, Lefteris C. Zacharia, Stylianopoulos, Triantafyllos
In many solid tumours a desmoplastic reaction takes place, which results in tumour tissue stiffening due to the extensive production of extracellular matrix (ECM) proteins, such as collagen, by stromal cells, mainly fibroblasts (FBs) and cancer assoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcf5fd643de24f8d6598c93587de4a2
Metastasis to distant organs and not the primary tumor itself is usually the cause of death for cancer patients. Hence, studying the key molecules and molecular pathways involved in metastasis is essential. Metastasis is a complex process in which ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e23d3a6db5d534419857abea662ee9c
https://europepmc.org/articles/PMC5985951/
https://europepmc.org/articles/PMC5985951/
Autor:
Lefteris C. Zacharia
Publikováno v:
Toxicological Sciences. 163:334-334
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee0d75739a0c1a8508e6446323b565f
https://doi.org/10.1093/toxsci/kfy074
https://doi.org/10.1093/toxsci/kfy074