Inhibitors of the small membrane (M) protein viroporin prevent Zika virus infection.

Autor: Brown E; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Swinscoe G; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Lefteri DA; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Singh R; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Chemistry, Faculty of Maths and Physical Sciences, University of Leeds, Leeds, United Kingdom., Moran A; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Thompson RF; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Maskell D; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Beaumont H; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Bentham MJ; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Donald C; MRC and University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, Glasgow, United Kingdom., Kohl A; MRC and University of Glasgow Centre for Virus Research, Sir Michael Stoker Building, Glasgow, United Kingdom., Macdonald A; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Ranson N; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom., Foster R; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; School of Chemistry, Faculty of Maths and Physical Sciences, University of Leeds, Leeds, United Kingdom., McKimmie CS; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom., Kalli AC; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute for Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom., Griffin S; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom.; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, St James' University Hospital, Leeds, United Kingdom.

Publikováno v: ELife [Elife] 2024 Aug 23; Vol. 13. Date of Electronic Publication: 2024 Aug 23.

Evidence of Differences in Cellular Regulation of Wolbachia -Mediated Viral Inhibition between Alphaviruses and Flaviviruses.

Autor: Rainey SM; MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasogw, Glasgow G61 1QH, UK., Lefteri DA; MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasogw, Glasgow G61 1QH, UK., Darby C; MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasogw, Glasgow G61 1QH, UK., Kohl A; MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasogw, Glasgow G61 1QH, UK.; Departments of Tropical Disease Biology and Vector Biology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK., Merits A; Institute of Technology, University of Tartu, 50411 Tartu, Estonia., Sinkins SP; MRC-University of Glasgow-Centre for Virus Research, Garscube Campus, University of Glasogw, Glasgow G61 1QH, UK.

Publikováno v: Viruses [Viruses] 2024 Jan 13; Vol. 16 (1). Date of Electronic Publication: 2024 Jan 13.

Mosquito  saliva enhances virus infection through sialokinin-dependent vascular leakage.

Autor: Lefteri DA; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Bryden SR; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Pingen M; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Terry S; MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, Scotland, United Kingdom., McCafferty A; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Beswick EF; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Georgiev G; Inflammatory Skin Disease Group, Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Van der Laan M; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Mastrullo V; Section of Cardiovascular Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom., Campagnolo P; Section of Cardiovascular Sciences, Faculty of Health & Medical Sciences, University of Surrey, Guildford, GU2 7XH, United Kingdom., Waterhouse RM; Department of Ecology and Evolution, Swiss Institute of Bioinformatics, University of Lausanne, 1015 Lausanne, Switzerland., Varjak M; MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, Scotland, United Kingdom., Merits A; Institute of Technology, University of Tartu, 50411 Tartu, Estonia., Fragkoudis R; School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, United Kingdom., Griffin S; Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Shams K; Inflammatory Skin Disease Group, Leeds Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom., Pondeville E; MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, Scotland, United Kingdom., McKimmie CS; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, LS9 7TF, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jun 14; Vol. 119 (24), pp. e2114309119. Date of Electronic Publication: 2022 Jun 08.

Pan-viral protection against arboviruses by activating skin macrophages at the inoculation site.

Autor: Bryden SR; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK.; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Pingen M; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK.; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Lefteri DA; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK., Miltenburg J; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK., Delang L; KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium., Jacobs S; KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium., Abdelnabi R; KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium., Neyts J; KU Leuven Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, 3000 Leuven, Belgium., Pondeville E; MRC‑University of Glasgow Centre for Virus Research, Glasgow G61 1QH, UK, Major J; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK.; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Müller M; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Khalid H; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Tuplin A; School of Molecular and Cellular Biology, Faculty of Biological Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Varjak M; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Merits A; Institute of Technology, University of Tartu, 50411 Tartu, Estonia., Edgar J; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Graham GJ; Institute of Infection, Immunology and Inflammation, University of Glasgow, Glasgow G12 8TA, UK., Shams K; Inflammatory Skin Disease Group, Institute of Rheumatic and Musculoskeletal Medicine, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK., McKimmie CS; Virus Host Interaction Team, Leeds Institute of Medical Research, School of Medicine, Faculty of Medicine and Health, University of Leeds, Leeds LS9 7TF, UK. c.s.mckimmie@leeds.ac.uk.

Publikováno v: Science translational medicine [Sci Transl Med] 2020 Jan 22; Vol. 12 (527).