Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Leeyup Chung"'
Publikováno v:
Neurobiology of Disease, Vol 110, Iss , Pp 12-19 (2018)
Epilepsy is prevalent and often medically intractable in Angelman syndrome (AS). AS mouse model (Ube3am−/p+) shows reduced excitatory neurotransmission but lower seizure threshold. The neural mechanism linking the synaptic dysfunction to the seizur
Externí odkaz:
https://doaj.org/article/0082dc84acac421492c82f07cf46503c
Autor:
Xiaoming Wang, Alexandra L. Bey, Brittany M. Katz, Alexandra Badea, Namsoo Kim, Lisa K. David, Lara J. Duffney, Sunil Kumar, Stephen D. Mague, Samuel W. Hulbert, Nisha Dutta, Volodya Hayrapetyan, Chunxiu Yu, Erin Gaidis, Shengli Zhao, Jin-Dong Ding, Qiong Xu, Leeyup Chung, Ramona M. Rodriguiz, Fan Wang, Richard J. Weinberg, William C. Wetsel, Kafui Dzirasa, Henry Yin, Yong-hui Jiang
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
SHANK3 mutations have been linked to autism spectrum disorders, although the underlying mechanisms remain unclear. Here, the authors generate a complete knockout Shank3 mouse model, identifying ASD-like behaviours associated with impaired mGluR5-Home
Externí odkaz:
https://doaj.org/article/31226ec3e0a84099b658a1cc0d12be11
Autor:
Philip A. Feinberg, Shannon C. Becker, Leeyup Chung, Loris Ferrari, David Stellwagen, Christelle Anaclet, Violeta Durán-Laforet, Travis E. Faust, Rachita K. Sumbria, Dorothy P. Schafer
Publikováno v:
J Neurosci
Interferon regulatory factor 8 (IRF8) is a transcription factor necessary for the maturation of microglia, as well as other peripheral immune cells. It also regulates the transition of microglia and other immune cells to a pro-inflammatory phenotype.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5026e33398d9e72dde9db2ded2fbaa0
https://europepmc.org/articles/PMC9374154/
https://europepmc.org/articles/PMC9374154/
Autor:
Jun Takatoh, Vincent Prevosto, P. M. Thompson, Jinghao Lu, Leeyup Chung, Andrew Harrahill, Shun Li, Shengli Zhao, Zhigang He, David Golomb, David Kleinfeld, Fan Wang
Publikováno v:
Nature
Central oscillators are primordial neural circuits that generate and control rhythmic movements (1,2). Mechanistic understanding of these circuits requires genetic identification of the oscillator neurons and their synaptic connections, to target ele
Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8.
Autor:
Feinberg, Philip A., Becker, Shannon C., Leeyup Chung, Ferrari, Loris, Stellwagen, David, Anaclet, Christelle, Durán-Laforet, Violeta, Faust, Travis E., Sumbria, Rachita K., Schafer, Dorothy P.
Publikováno v:
Journal of Neuroscience; 8/10/2022, Vol. 42 Issue 32, p6171-6185, 15p
Autor:
Yulong Li, Steven R. DeGroot, Paul D. Gardner, Paul M. Klenowski, Andrew R. Tapper, Susanna Molas, Rubing Zhao-Shea, Leeyup Chung, Fangmiao Sun
Publikováno v:
Biol Psychiatry
Background Dopamine (DA) is hypothesized to modulate anxiety-like behavior, although the precise role of DA in anxiety behaviors and the complete anxiety network in the brain have yet to be elucidated. Recent data indicate that dopaminergic projectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0b57187a1f7121751cff29f28a0ad8
https://europepmc.org/articles/PMC8043246/
https://europepmc.org/articles/PMC8043246/
Autor:
Scott D. Moore, Monisha Sachdev, Qiang Li, Melanie Masoud, Mohamad A. Mikati, Elie Abdelnour, Jordan Richardson, Arsen S. Hunanyan, Leeyup Chung, J. Victor Nadler, Ashley Helseth, Bassil Kherallah
Publikováno v:
Epilepsia. 59:1455-1468
Objective Na+ /K+ -ATPase dysfunction, primary (mutation) or secondary (energy crisis, neurodegenerative disease) increases neuronal excitability in the brain. To evaluate the mechanisms underlying such increased excitability we studied mice carrying
Publikováno v:
Neurobiology of Disease, Vol 110, Iss, Pp 12-19 (2018)
Epilepsy is prevalent and often medically intractable in Angelman syndrome (AS). AS mouse model (Ube3am−/p+) shows reduced excitatory neurotransmission but lower seizure threshold. The neural mechanism linking the synaptic dysfunction to the seizur
Autor:
Arsen S, Hunanyan, Ashley R, Helseth, Elie, Abdelnour, Bassil, Kherallah, Monisha, Sachdev, Leeyup, Chung, Melanie, Masoud, Jordan, Richardson, Qiang, Li, J Victor, Nadler, Scott D, Moore, Mohamad A, Mikati
Publikováno v:
Epilepsia. 59(7)
NaWe performed extracellular recordings, as well as whole-cell patch clamp recordings from pyramidal cells and interneurons, in the CA1 region on hippocampal slices. We also performed immunohistochemistry from hippocampal sections to count CA1 pyrami
Autor:
Edgar Garcia-Rill, Young-Jin Kang, Gubbi Govindaiah, Hannah Elisabeth Smashey Lewis, Lazar John Greenfield, Leeyup Chung, Sang-Hun Lee, Ethan M. Clement
Publikováno v:
Neuropharmacology. 139
GABAergic interneurons in the hippocampus are critically involved in almost all hippocampal circuit functions including coordinated network activity. Somatostatin-expressing orienslacunosum moleculare (O-LM) interneurons are a major subtype of dendri