Výsledky vyhledávání - "Leesa Bryant"

Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway

Autor: Timothy M. Doyle, Frank Porreca, Mahsa Mohammadebrahim Ghaffari, William L. Neumann, Leesa Bryant, Joshua W. Little, Zhoumou Chen, Daniela Salvemini

Publikováno v: The Journal of Neuroscience. 32:10797-10808

Peroxynitrite (PN, ONOO−) is a potent oxidant and nitrating agent that contributes to pain through peripheral and spinal mechanisms, but its supraspinal role is unknown. We present evidence here that PN in the rostral ventromedial medulla (RVM) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99403e188abab1a39c05b2c708586c9e
https://doi.org/10.1523/jneurosci.6345-11.2012

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ECG Detection of Murine Chagasic Cardiomyopathy

Autor: Arthur J. Labovitz, Cade T. Lawrence, John E. Sagartz, Simil S. Gala, Daniel F. Hoft, Leesa Bryant, Christopher S. Eickhoff

Publikováno v: Journal of Parasitology. 96:758-764

Chagas' disease, induced by Trypanosoma cruzi , is a common cause of infectious myocarditis. Recent clinical treatment trials and vaccine studies indicate that chagasic immunopathology is directed against the parasite and not self-antigens. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04e085cc07e2bba98696fde6bca0945
https://doi.org/10.1645/ge-2396.1

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Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance

Autor: Daniela N. Petrusca, Zhoumo Chen, Timothy M. Doyle, Irina Petrache, Daniela Salvemini, Emanuela Mazzon, Emanuela Masini, Emanuela Esposito, Salvatore Cuzzocrea, Leesa Bryant, M. Cristina Vinci

Publikováno v: Neuroscience Letters. 463:49-53

Opiates, like morphine, are the most effective analgesics for treating acute and chronic severe pain, but their use is limited by the development of analgesic tolerance and hypersensitivity to innocuous and noxious stimuli. Because opioids are a main

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2d90b262ce25a90efd56b8bf6aabdc
https://doi.org/10.1016/j.neulet.2009.07.051

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The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1

Autor: Joshua W. Little, Kali Janes, Ashley J. Snider, Irina Petrache, Daniela Salvemini, William L. Neumann, Lina M. Obeid, Leesa Bryant, Emanuela Esposito, Erhard Bieberich, Chao Li, Zhoumou Chen, Grant D. Nicol, Collin L. Chen, Krzysztof Kamocki, Salvatore Cuzzocrea, Timothy M. Doyle

Publikováno v: The Journal of biological chemistry. 289(30)

The ceramide-sphingosine 1-phosphate (S1P) rheostat is important in regulating cell fate. Several chemotherapeutic agents, including paclitaxel (Taxol), involve pro-apoptotic ceramide in their anticancer effects. The ceramide-to-S1P pathway is also i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::580208213ad29404b8bd48ccf311705d
https://pubmed.ncbi.nlm.nih.gov/24876379

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Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

Autor: Emanuela Esposito, Jan S. Ryerse, Kali Janes, Timothy M. Doyle, Daniela Salvemini, Salvatore Cuzzocrea, Gary J. Bennett, Leesa Bryant

Publikováno v: Pain. 154(11)

Many of the widely used anticancer drugs induce dose-limiting peripheral neuropathies that undermine their therapeutic efficacy. Animal models of chemotherapy-induced painful peripheral neuropathy (CIPN) evoked by a variety of drug classes, including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875ee119319bcc833b639fb406d26027
https://pubmed.ncbi.nlm.nih.gov/23891899

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NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice

Autor: Emanuela Esposito, Leesa Bryant, Salvatore Cuzzocrea, Daniela Salvemini, Timothy M. Doyle

The analgesic effectiveness of long-term opioid therapies is compromised by the development of antinociceptive tolerance linked to the overt production of peroxynitrite (ONOO(-), PN), the product of the interaction between superoxide (O2(-), SO) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b024f32f73e8f0f5a2d114ed63d4f57
https://europepmc.org/articles/PMC4184413/

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Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

Autor: Emanuela Esposito, William L. Neumann, Leesa Bryant, Timothy M. Doyle, Joshua W. Little, Smita Rausaria, Daniela Salvemini, Salvatore Cuzzocrea

Treatment of severe pain by morphine, the gold-standard opioid and a potent drug in our arsenal of analgesic medications, is limited by the eventual development of hyperalgesia and analgesic tolerance. We recently reported that systemic administratio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b23e5900407c960ae9d6867d37ec1eec
http://hdl.handle.net/11570/2541030

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Controlling murine and rat chronic pain through A3 adenosine receptor activation

Autor: Kenneth A. Jacobson, Dilip K. Tosh, Leesa Bryant, Kali Janes, Zhoumou Chen, Daniela Salvemini, Collin L. Chen, Timothy M. Doyle

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(5)

Clinical management of chronic neuropathic pain is limited by marginal effectiveness and unacceptable side effects of current drugs. We demonstrate A3 adenosine receptor (A3AR) agonism as a new target-based therapeutic strategy. The development of me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a2d94ca061529d75b13a4cc3827d08
https://pubmed.ncbi.nlm.nih.gov/22345405

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