OP02. NOVEL DNA METHYLATION LANDSCAPE OF METASTATIC COLORECTAL CANCER REVEALS SIGNIFICANT EPIGENETIC REGULATION OF DISEASEASSOCIATED ENHANCER REGIONS

Autor: Cosgrove, Donna, Whitton, L, Donohoe, G, Morris, DW, Das, Sudipto, Moran, B, Smeets, D, Kel, A, George, S, Van Brussel, T, Peutman, G, Klinger, R, Fender, B, Connor, K, Ebert, M, Gaiser, T, Prehn, JHM, Bacon, O, Kay, E, Hennessy, B, Murphy, V, Byrne, A, Gallagher, WM, Lambrechts, D, O’Connor, D, Murphy, Therese M, Crawford, B, Craig, Z, Mansell, G, White, I, Smith, A, Spaull, S, Imm, J, Hannon, E, Wood, A, Yaghootkar, H, Ji, Y, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mullins, N, Lewis, CM, Mill, J, Shortall, Ciara, Palfi, A, Chadderton, N, Kenna, PF, Carrigan, M, Boomkamp, S, Shen, S, Hardcastle, AJ, Farrar, GJ, Walsh, Naomi, Nelson, S, Zhang, H, Stolzenberg-Solomon, R, Patrick Byrne, Ross, van Rheenen, W, van den Berg, LH, Veldink, JH, McLaughlin, RL, Cassidy, Lara, Bradley, D, Gunne, Emer, Ward, A, Treacy, E, Lambert, D, Lynch, SA, Kostocenko, Marija, Lang, N, Clark, T, Barton, DE, McVeigh, Terri, Kelly, LJ, Whitmore, E, Mullaney, B, Savage, Sarah, Rakovac-Tisdall, A, Rasheed, E, Mac Namara, B, Keogh, E, O’Connor, P, Durkan, M, Maher, V, Griffin, D, MacAdam, B, Vaughan, C, Ryan, M, Heggarty, S, Hart, P, Crowley, VEF, Mullaney, Brendan, McQuaid, S, O’Brien, C, McDevitt, T, Brosnan, K, Logan, Peter, Byrne, C, Scott, J, Dabir, T, Amenyah, Sophia.D, McMahon, A, Ward, M, Deane, J, McNulty, H, Hughes, CF, Strain, JJ, Horigan, G, Purvis, J, Walsh, CP, Lees-Murdock, DJ, Anderson, Kerry, Cañadas-Garre, M, Maxwell, AP, McKnight, AJ, Angel, Zoe, McKenna, DJ, Ariano, Bruno, Mattiangeli, V, Cassidy, LM, McLaughlin, TR, Power, RK, Stock, JT, Mercieca-Spiteri, B, Stoddart, S, Malone, C, Bradley, DG, Atkinson, Sarah D, Campbell, N, Windrum, L, Hassett, P, Bjourson, AJ, Breslin, Emily, Martiniano, R, Silva, AM, Campbell, Ciaran, McCormack, M, Stapleton, C, the EpiPGX Consortium CP Doherty, Delanty, N, Cavalleri, GL, Cooke, Niall, Nakagome, S, D’Cruz, Leon.G, McEleney, K, Tan, K.B.C, Cobice, D, Dobbins, S, Tahanver, A, McLaughlin, C, Conway, C, Small, D, Connolly, C, Gardiner, P, Gibson, D, Flynn, Mairead, Gill, M, Corvin, A, Morris, D, Morrison, CG, Gilbert, Edmund, O’Reilly, S, Merrigan, M, McGettingan, D, Vitart, V, Joshi, PK, Clark, DW, Campbell, H, Hayward, C, Ring, S, Golding, J, Timpson, N, Navarro, P, Kerr, SM, Amador, C, Campbell, A, Haley, CS, Porteous, DJ, Wilson, JF, McNicholas, Áine, Cosgrove, D, Mothersill, DO, Holleran, L, Holland, J, Dauvermann, M, Salter-Townshend, Michael, Myers, SR, Stapleton, Caragh P, On behalf of the UK and Ireland Renal Transplant Consortium, Conlon, PJ, Villikudathil, Angelina T, McGuigan, D, English, A, C, Kelly, McClean, P, Bjourson, T, Shukla, P, Walsh, Darren J, Parle-McDermott, A, Whitton, Laura, Pardinas, A, Walters, J, Yesmambetov, Adlet, Kenna, P, O’Connor, D P, Zang, Jinnan, Simpson, DA, McKay, GJ, Crowley, Vivion, Walsh, E, Abdelfadil, S, Savage, S, MacNamara, B, McKiernan, S, Pazsderska, A, Murphy, R, McCarroll, K, D’Cruz, Leon G, Husain, SA, Yousef, Z, Edkins, S, Ashelford, K, Lai, FA, Duff, Marie, Cody, N, Clabby, C, McVeigh, TP, Green, AJ, Hengeveld, Jennifer, Doherty, MA, Dupuis, L, Vajda, A, Heverin, M, Hardiman, O, Lang, Niamh, O’Byrne, JJ, Kelly, RM, McKenna, Caoimhe, Morrison, P, Lakhanpaul, M, Saxena, N, Dabir, TA, Jones, J, Smith, G, Morrison, PJ, Znaczko, A, Hurrell, D, Donnelly, D, Al Shehhii, M, Jones, E. A., Murray, A, Wedderburn, S, Porteous, M, McVeigh, Úna M, Miller, N, Kerin, MJ, Ghrálaigh, Fiana Ní, Kenny, E, Gallagher, L, Lopez, LM, O’Byrne, James J, Byrne, N, Tapiea, D, Abidin, Z, Pastores, GM, Treacy, EP, Sasaki, Erina, McVeigh, T, O’Hici, B, O’Connell, S, Betts, D, McArdle, L, Hegarty, A, Gill, H, Flanagan, O, McMahon, C, Bradley, L, Scott, Janice, Martin, R, Logan, P, Ward, Alana, Giffney, C, Peyton, C, Turner, J, White, N, Znaczko, Anna, Benson, Katherine A, Kennedy, C, Murray, S, Conlon, P, Dwane, Lisa, Das, S, O’Connor, A E, Mulrane, L, Dirac, A M, Mooney, B, Jirstrom, K, Crown, J P, Bernards, R, Gallagher, W M, Ní Chonghaile, T

Publikováno v: The Ulster Medical Journal

Myocyte enhancer factor 2 C (MEF2C) is a transcription factor that plays a central role regulating cell differentiation, proliferation, survival and apoptosis. MEF2C has been implicated in each of the most recent GWAS of cognitive ability (CA) and ed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::696620cc9e9e6755a0ff119845fdcc13
http://europepmc.org/articles/PMC6342039

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Folic acid intervention during pregnancy alters DNA methylation, affecting neural target genes through two distinct mechanisms.

Autor: Ondičová M; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK., Irwin RE; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK., Thursby SJ; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK.; The Johns Hopkins University School of Medicine, Baltimore, USA., Hilman L; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK., Caffrey A; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Cassidy T; Psychology Institute, Ulster University, Coleraine, Northern Ireland, UK., McLaughlin M; Psychology Institute, Ulster University, Coleraine, Northern Ireland, UK., Lees-Murdock DJ; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK., Ward M; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Murphy M; Unitat de Medicina Preventiva i Salut Pública, Facultat de Medicina i Ciències de La Salut, Universitat Rovira i Virgili, Reus, Spain., Lamers Y; Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, and British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada., Pentieva K; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., McNulty H; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Walsh CP; Genomic Medicine Research Group, Ulster University, Coleraine, Northern Ireland, UK. cp.walsh@ulster.ac.uk.; Centre for Research and Development, Region Gävleborg/Uppsala University, Gävle, Sweden. cp.walsh@ulster.ac.uk.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2022 May 16; Vol. 14 (1), pp. 63. Date of Electronic Publication: 2022 May 16.

Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial.

Autor: Caffrey A; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK., McNulty H; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK., Rollins M; Northern Health and Social Care Trust, Causeway Hospital, Coleraine, Northern Ireland, UK., Prasad G; Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK., Gaur P; Intelligent Systems Research Centre, Ulster University, Derry~Londonderry, Northern Ireland, UK.; Department of Computer Science, BITS Pilani, Dubai campus, Dubai, United Arab Emirates., Talcott JB; Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK., Witton C; Institute of Health and Neurodevelopment, College of Health and Life Sciences, Aston University, Birmingham, UK., Cassidy T; Psychology Research Institute, Ulster University, Coleraine, Northern Ireland, UK., Marshall B; Northern Health and Social Care Trust, Causeway Hospital, Coleraine, Northern Ireland, UK., Dornan J; Royal-Jubilee Maternity Service, Belfast, Northern Ireland, UK., Moore AJ; School of Environmental Sciences, Ulster University, Coleraine, Northern Ireland, UK., Ward M; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK., Strain JJ; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK., Molloy AM; School of Medicine, Trinity College, Dublin, Ireland., McLaughlin M; Psychology Research Institute, Ulster University, Coleraine, Northern Ireland, UK., Lees-Murdock DJ; Genomics Medicine Research Group, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Walsh CP; Genomics Medicine Research Group, School of Biomedical Sciences, Ulster University, Coleraine, Northern Ireland, UK., Pentieva K; Nutrition Innovation Centre for Food and Health (NICHE), School of Biomedical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK. k.pentieva@ulster.ac.uk.

Publikováno v: BMC medicine [BMC Med] 2021 Mar 10; Vol. 19 (1), pp. 73. Date of Electronic Publication: 2021 Mar 10.