Delineation of the complete reaction cycle of a natural Diels-Alderase.

Autor: Maschio L; School of Biochemistry, University Walk, University of Bristol BS8 1TD UK., Back CR; School of Biochemistry, University Walk, University of Bristol BS8 1TD UK., Alnawah J; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk.; Department of Chemistry, King Faisal University, College of Science Al-Ahsa 31982 Saudi Arabia., Bowen JI; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk., Johns ST; School of Biochemistry, University Walk, University of Bristol BS8 1TD UK., Mbatha SZ; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk., Han LC; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk., Lees NR; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk., Zorn K; Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca Pepparedsleden 1 431 83 Mölndal Sweden., Stach JEM; School of Natural and Environmental Sciences, Newcastle University NE1 7RU UK paul.race1@newcastle.ac.uk., Hayes MA; Discovery Sciences, Biopharmaceuticals R&D, AstraZeneca Pepparedsleden 1 431 83 Mölndal Sweden., van der Kamp MW; School of Biochemistry, University Walk, University of Bristol BS8 1TD UK., Pudney CR; Department of Biology and Biochemistry, University of Bath Claverton Down BA2 7AY UK., Burston SG; School of Biochemistry, University Walk, University of Bristol BS8 1TD UK., Willis CL; School of Chemistry, University of Bristol Cantock's Close BS8 1TS UK Chris.Willis@bristol.ac.uk., Race PR; School of Natural and Environmental Sciences, Newcastle University NE1 7RU UK paul.race1@newcastle.ac.uk.

Publikováno v: Chemical science [Chem Sci] 2024 Jun 24; Vol. 15 (29), pp. 11572-11583. Date of Electronic Publication: 2024 Jun 24 (Print Publication: 2024).

The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.

Autor: Devine AJ; School of Chemistry, University of Bristol, BS81TS, Bristol, UK., Parnell AE; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Back CR; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Lees NR; School of Chemistry, University of Bristol, BS81TS, Bristol, UK., Johns ST; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Zulkepli AZ; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Barringer R; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Zorn K; BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183, Mölndal, Sweden., Stach JEM; School of Natural and Environmental Sciences, Newcastle University, NE17RU, Newcastle-upon-Tyne, UK., Crump MP; School of Chemistry, University of Bristol, BS81TS, Bristol, UK., Hayes MA; BioPharmaceuticals R&D, AstraZeneca, Pepparedsleden 1, 43183, Mölndal, Sweden., van der Kamp MW; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Race PR; School of Biochemistry, University of Bristol, BS81TD, Bristol, UK., Willis CL; School of Chemistry, University of Bristol, BS81TS, Bristol, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2023 Jan 16; Vol. 62 (3), pp. e202213053. Date of Electronic Publication: 2022 Dec 08.

General Method for the Synthesis of α- or β-Deoxyaminoglycosides Bearing Basic Nitrogen.

Autor: Hoang KM; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Lees NR; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States., Herzon SB; Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.; Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520, United States.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2021 Feb 24; Vol. 143 (7), pp. 2777-2783. Date of Electronic Publication: 2021 Feb 08.

Synthesis and reactivity of precolibactin 886.

Autor: Healy AR; Department of Chemistry, Yale University, New Haven, CT, USA.; Chemical Biology Institute, Yale University, West Haven, CT, USA., Wernke KM; Department of Chemistry, Yale University, New Haven, CT, USA., Kim CS; Department of Chemistry, Yale University, New Haven, CT, USA.; Chemical Biology Institute, Yale University, West Haven, CT, USA., Lees NR; Department of Chemistry, Yale University, New Haven, CT, USA., Crawford JM; Department of Chemistry, Yale University, New Haven, CT, USA. jason.crawford@yale.edu.; Chemical Biology Institute, Yale University, West Haven, CT, USA. jason.crawford@yale.edu.; Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, USA. jason.crawford@yale.edu., Herzon SB; Department of Chemistry, Yale University, New Haven, CT, USA. seth.herzon@yale.edu.; Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA. seth.herzon@yale.edu.

Publikováno v: Nature chemistry [Nat Chem] 2019 Oct; Vol. 11 (10), pp. 890-898. Date of Electronic Publication: 2019 Sep 23.

An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.

Autor: Lees NR; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Han LC; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Byrne MJ; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Davies JA; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Parnell AE; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Moreland PEJ; School of Biology, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.; Centre for Synthetic Biology and the Bioeconomy, Newcastle-upon-Tyne, NE2 4AX, UK., Stach JEM; School of Biology, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.; Centre for Synthetic Biology and the Bioeconomy, Newcastle-upon-Tyne, NE2 4AX, UK., van der Kamp MW; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Willis CL; School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK., Race PR; School of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK.; BrisSynBio Synthetic Biology Research Centre, University of Bristol, Bristol, BS8 1TQ, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2019 Feb 18; Vol. 58 (8), pp. 2305-2309. Date of Electronic Publication: 2019 Jan 21.