Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leepakshi Khurana"'
Publikováno v:
Neuropharmacology. 124:3-12
Cannabinoid pharmacology has been intensely studied because of cannabis' pervasive medicinal and non-medicinal uses as well as for the therapeutic potential of cannabinoid-based drugs for the treatment of pain, anxiety, substance abuse, obesity, canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1852cc24accf97e6aeb6140af60cdd82
https://doi.org/10.1016/j.neuropharm.2017.05.018
https://doi.org/10.1016/j.neuropharm.2017.05.018
Autor:
Boqiao Fu, Sri Sujana Immadi, Anantha Lakshmi Duddupudi, Dai Lu, Debra A. Kendall, Yu-Hsien Liao, Leepakshi Khurana
Publikováno v:
Journal of Medicinal Chemistry. 60:1089-1104
The allosteric modulator 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea (PSNCBAM-1, 2) bound the cannabinoid receptor 1 (CB1) and antagonized G protein coupling. This compound demonstrated potent anorectic effects similar to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::729ba040af197ad8a07732775dff5669
https://doi.org/10.1021/acs.jmedchem.6b01448
https://doi.org/10.1021/acs.jmedchem.6b01448
Publikováno v:
Methods in enzymology. 629
Several fundamental discoveries made over the last two decades, in the field of cancer biology, have increased our understanding of the complex tumor micro- and macroenvironments. This has shifted the current empirical cancer therapies to more ration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dde2e294b6249efbbab73f4647aa0df5
https://pubmed.ncbi.nlm.nih.gov/31727247
https://pubmed.ncbi.nlm.nih.gov/31727247
Autor:
Elias Lolis, Anthony K Ma, Krystle Reiss, Leepakshi Khurana, George P. Lisi, Georgios Pantouris, Erin Skeens, Victor S. Batista
Publikováno v:
Cell Chem Biol
In proteins with multiple functions, such as macrophage migration inhibitory factor (MIF), the study of its intramolecular dynamic network can offer a unique opportunity to understand how a single protein is able to carry out several nonoverlapping f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd17b5eb2a87960d8a870795f8366bf1
https://pubmed.ncbi.nlm.nih.gov/32433911
https://pubmed.ncbi.nlm.nih.gov/32433911
Several fundamental discoveries made over the last two decades, in the field of cancer biology, have increased our understanding of the complex tumor micro- and macroenvironments. This has shifted the current empirical cancer therapies to more ration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::389090746504b3f72742c8c9f070badb
https://doi.org/10.1016/bs.mie.2019.05.053
https://doi.org/10.1016/bs.mie.2019.05.053
Autor:
Leepakshi, Khurana, Bo-Qiao, Fu, Anantha L, Duddupudi, Yu-Hsien, Liao, Sri Sujana, Immadi, Debra A, Kendall, Dai, Lu
Publikováno v:
Journal of medicinal chemistry. 60(3)
The allosteric modulator 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea (PSNCBAM-1, 2) bound the cannabinoid receptor 1 (CB1) and antagonized G protein coupling. This compound demonstrated potent anorectic effects similar to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e05eec21482767d20c602dde14e9cdc5
https://pubmed.ncbi.nlm.nih.gov/28059509
https://pubmed.ncbi.nlm.nih.gov/28059509
Despite the important role of the carboxyl-terminus (Ct) of the activated brain cannabinoid receptor one (CB1) in the regulation of G protein signaling, a structural understanding of interactions with G proteins is lacking. This is largely due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef10f5889e6192fe69eaf4fdf2ef2567
Autor:
Tania Tahtouh, Emilie Durieu, Benoît Villiers, Céline Bruyère, Thu Lan Nguyen, Xavier Fant, Kwang H. Ahn, Leepakshi Khurana, Emmanuel Deau, Mattias F. Lindberg, Elodie Sévère, Frédéric Miege, Didier Roche, Emmanuelle Limanton, Jean-Martial L’Helgoual’ch, Guillaume Burgy, Solène Guiheneuf, Yann Herault, Debra A. Kendall, François Carreaux, Jean-Pierre Bazureau, Laurent Meijer
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2022, ⟨10.1021/acs.jmedchem.1c01141⟩
Journal of Medicinal Chemistry, 2022, 65 (2), pp.1396-1417. ⟨10.1021/acs.jmedchem.1c01141⟩
Journal of Medicinal Chemistry, American Chemical Society, 2022, ⟨10.1021/acs.jmedchem.1c01141⟩
Journal of Medicinal Chemistry, 2022, 65 (2), pp.1396-1417. ⟨10.1021/acs.jmedchem.1c01141⟩
International audience; The protein kinase DYRK1A is involved in Alzheimer's disease, Down syndrome, diabetes, viral infections, and leukemia. Leucettines, a family of 2-aminoimidazolin-4-ones derived from the marine sponge alkaloid Leucettamine B, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b69d0950240f3edb4ed4b932320217
Publikováno v:
Communications Biology; 2/10/2020, Vol. 3 Issue 1, p1-9, 9p
Publikováno v:
Proteins; Apr2016, Vol. 84 Issue 4, p532-543, 12p