Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leeona Galligan"'
Autor:
Richard D. Kennedy, James R. Bradford, Eileen Parkes, Emma O'Connor, Laura A. Knight, Shauna Lambe, Leeona Galligan, Nuala McCabe, Paul Harkin, Gemma E Logan, Steven Walker
Publikováno v:
Journal of Clinical Oncology. 37:e21045-e21045
e21045 Background: Traditionally gene expression signatures (GES) are used individually to classify patients into subgroups. Signatures targeting the same biology are often developed independently and may not classify identically. We developed the cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80ee487193406a01a2517c19233b322
https://doi.org/10.1200/jco.2019.37.15_suppl.e21045
https://doi.org/10.1200/jco.2019.37.15_suppl.e21045
Autor:
M. Drake, C Hodkinson, P Kettle, H.D. Alexander, Stephen Drain, Treen C. M. Morris, Nick Orr, Irene Maeve Rea, Mark Catherwood, Leeona Galligan
Publikováno v:
Leukemia & Lymphoma. 50:566-570
Multi-drug resistance (MDR) may compromise the successful management of haematological malignancies, impairing the effectiveness of chemotherapy. The P-glycoprotein (P-gp) drug efflux pump, encoded by the gene ABCB1 (MDR1), is the most widely studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03993bb78fbfd418cc6debcefeaba50c
https://doi.org/10.1080/10428190902853144
https://doi.org/10.1080/10428190902853144
Autor:
Kirsty McLaughlin, Daniel B. Longley, Leeona Galligan, Miranda McEwan, Patrick G. Johnston, Timothy R. Wilson
Publikováno v:
Molecular Cancer Therapeutics. 4:2026-2036
Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has recently attracted attention as a potential therapeutic agent in the treatment of cancer. We assessed the roles of p53, TRAIL receptors, and cellular Fas-associated death domain–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e737c8ce955c06a2bf33064e529b61
https://doi.org/10.1158/1535-7163.mct-05-0262
https://doi.org/10.1158/1535-7163.mct-05-0262
Autor:
Leeona Galligan, Miranda McEwan, Patrick G. Johnston, Wendy L. Allen, Timothy R. Wilson, Daniel B. Longley, Ultan McDermott
Publikováno v:
Oncogene. 25:838-848
c-FLIP inhibits caspase 8 activation and apoptosis mediated by death receptors such as Fas and DR5. We studied the effect of c-FLIP on the apoptotic response to chemotherapies used in colorectal cancer (CRC) (5-fluorouracil, oxaliplatin and irinoteca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c0a388e6f291d72dc4b6370e9f3483
https://doi.org/10.1038/sj.onc.1209122
https://doi.org/10.1038/sj.onc.1209122
Autor:
Anthi Karaiskou-McCaul, Eric Van Cutsem, Daniel B. Longley, Patrick G. Johnston, Leeona Galligan, Donal M. Kelly, Sandra Van Schaeybroeck
Publikováno v:
Clinical Cancer Research. 11:7480-7489
Purpose: Up to now, there have been no established predictive markers for response to epidermal growth factor receptor (EGFR/HER1/erbB1) inhibitors alone and in combination with chemotherapy in colorectal cancer. To identify markers that predict resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3579eb14a90e187278c9202543f4ac
https://doi.org/10.1158/1078-0432.ccr-05-0328
https://doi.org/10.1158/1078-0432.ccr-05-0328
Autor:
Yuri Volkov, Leeona Galligan, Mark Lawler, Karsten Hokamp, Wendy Livingstone, Owen P. Smith, Kenji Fukudome, Ciaran Murphy
Publikováno v:
British Journal of Haematology. 115:408-414
Many sequelae associated with endotoxaemic-induced shock result from excessive production of the cytokine mediators, tumour necrosis factor alpha (TNF-alpha), interleukin 1 (IL-1) and IL-6 from lipopolysaccharide (LPS)-activated monocytes. Protein C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8ea89a60623654edfe063bad2204f44
https://doi.org/10.1046/j.1365-2141.2001.03187.x
https://doi.org/10.1046/j.1365-2141.2001.03187.x
Publikováno v:
Thrombosis and Haemostasis. 88:163-165
The G7763C Endothelial Protein C Receptor (EPCR) Gene Mutation: Prevalence and Association with DVT in the Irish Population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db2377210985961f566a330a782bfd9
https://doi.org/10.1055/s-0037-1613174
https://doi.org/10.1055/s-0037-1613174
Autor:
Christine Matthews, H. Dennis Alexander, T.C.M. ‘Curly’ Morris, Mark Catherwood, Leeona Galligan
Publikováno v:
Leukemialymphoma. 49(4)
Biased IgHV gene usage in chronic lymphocytic leukemia (CLL) is well documented and suggests antigen involvement in leukemogenesis. IgHV1-69 is one of the most frequently rearranged IgHV genes in CLL and the majority of IgHV1-69 cases lack somatic hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897ed4b47db7ba78c6902918f7f03d01
https://pubmed.ncbi.nlm.nih.gov/18398727
https://pubmed.ncbi.nlm.nih.gov/18398727
Autor:
Leeona Galligan, Patrick G. Johnston, M. Thomas, Hidekazu Sakai, Daniel B. Longley, Timothy R. Wilson, Katherine Rogers, Wendy L. Allen
Publikováno v:
Molecular cancer therapeutics. 6(5)
Combination treatment regimens that include topoisomerase-II–targeted drugs, such as doxorubicin, are widely used in the treatment of breast cancer. Previously, we showed that IFN-γ and doxorubicin cotreatment synergistically induced apoptosis in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a2140ada71fad42f88d8ff98dbcc68
https://pubmed.ncbi.nlm.nih.gov/17513603
https://pubmed.ncbi.nlm.nih.gov/17513603
Autor:
Timothy R. Wilson, Ultan McDermott, Wendy L. Allen, Patrick G. Johnston, Daniel B. Longley, Leeona Galligan
Publikováno v:
Cancer research. 65(19)
We investigated the role of p53 and the signal transducer and activator of transcription 1 (STAT1) in regulating Fas-mediated apoptosis in response to chemotherapies used to treat colorectal cancer. We found that 5-fluorouracil (5-FU) and oxaliplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715b43f25a55cf6a4788cfd64d30aeae
https://pubmed.ncbi.nlm.nih.gov/16204068
https://pubmed.ncbi.nlm.nih.gov/16204068