Výsledky vyhledávání - "Leenus, Martin"

Data from Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

Autor: Alexander Drilon, Marc Ladanyi, Pratik Multani, Rupal Patel, Jennifer W. Oliver, Ge Wei, Shunqi Yan, Jason Harris, Gregory J. Riely, Eric Martin, Anni Schairer, Aleksandra Franovic, Leenus Martin, Takuo Hayashi, Roger S. Smith, James Joseph, Romel Somwar, Gang G. Li

Purpose: While multikinase inhibitors with RET activity are active in RET-rearranged thyroid and lung cancers, objective response rates are relatively low and toxicity can be substantial. The development of novel RET inhibitors with improved potency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b105702602221e55d28aa4cdca2dd19
https://doi.org/10.1158/1078-0432.c.6525270.v1

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Abstract 3345: ERAS-601, a potent inhibitor of SHP2, synergistically enhances the activity of a FLT3 inhibitor, gilteritinib, in FLT3-mutated AML tumor models

Autor: Leenus Martin, Roopal Patel, Jingchuan Zhang, Robin Nevarez, Taylor Congdon, Les Brail, Robert Shoemaker

Publikováno v: Cancer Research. 82:3345-3345

ERAS-601 is a potent, small molecule allosteric inhibitor of wildtype SHP2, a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. ERAS-601 inhibits wildtype SHP2 biochemically with an IC50 of 4.6 nM and demonstrates selectivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0080ecb628c7d3f0cbcb35c3c83753c
https://doi.org/10.1158/1538-7445.am2022-3345

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Abstract 2669: ERAS-007 (ERK inhibitor) + ERAS-601 (SHP2 inhibitor) exhibit nonclinical combination activity across KRAS mutated NSCLC, CRC, and PDAC tumor models

Autor: Leenus Martin, Erin D. Lew, Roopal Patel, Joanne Oh, Jingchuan Zhang, Robin Nevarez, Taylor Congdon, Wei Lin, Les Brail, Robert Shoemaker

Publikováno v: Cancer Research. 82:2669-2669

KRAS mutations occur in about 25% of all cancers and promote oncogenesis via constitutive activation of the RAS/MAPK pathway. Targeting KRAS mutant tumors by inhibiting individual nodes in the RAS/MAPK pathway, including SHP2, SOS1, KRAS, RAF, MEK, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60b038ca8f5fed99c0184034f96168a6
https://doi.org/10.1158/1538-7445.am2022-2669

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Abstract 2670: ERAS-601, a potent allosteric inhibitor of SHP2, synergistically enhances the efficacy of sotorasib/adagrasib and cetuximab in NSCLC, CRC, and HNSCC tumor models

Autor: Leenus Martin, Roopal Patel, Jingchuan Zhang, Robin Nevarez, Taylor Congdon, Les Brail, Robert Shoemaker

Publikováno v: Cancer Research. 82:2670-2670

ERAS-601 is a potent, small molecule allosteric inhibitor of wildtype SHP2, a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. ERAS-601 inhibits wild type SHP2 biochemically with an IC50 of 4.6 nM and demonstrates selectivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c90fa8e7628b87f728cb760e0cc35865
https://doi.org/10.1158/1538-7445.am2022-2670

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Abstract 2671: ERAS-601, a potent allosteric inhibitor of SHP2, demonstrates anti-tumor activity in RAS/MAPK-driven tumor models

Autor: Leenus Martin, Roopal Patel, Jingchuan Zhang, Jennifer Yang, Robin Nevarez, Taylor Congdon, Les Brail, Robert Shoemaker

Publikováno v: Cancer Research. 82:2671-2671

SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene. SHP2 transduces upstream receptor tyrosine kinase (RTK) signaling to the RAS/MAPK pathway via its phosphatase-mediated regulation of guanine nucleotide exchange fac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84abeb7491994e27f8761c4f64de95a6
https://doi.org/10.1158/1538-7445.am2022-2671

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Antitumor Activity of RXDX-105 in Multiple Cancer Types with RET Rearrangements or Mutations

Autor: Jennifer W. Oliver, Gang G Li, Ge Wei, Annelie E. Abrahamsson Schairer, Romel Somwar, Takuo Hayashi, Aleksandra Franovic, Pratik S. Multani, Rupal Patel, James Joseph, Shunqi Yan, Marc Ladanyi, Leenus Martin, Gregory J. Riely, Eric S. Martin, Alexander Drilon, Jason Harris, Roger S. Smith

Publikováno v: Clinical Cancer Research. 23:2981-2990

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63d8950f51ca5bdd465056e4fce2dddd
https://doi.org/10.1158/1078-0432.ccr-16-1887

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Stress-induced inhibition of nonsense mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11

Autor: Leenus Martin, Lawrence B. Gardner

Publikováno v: Oncogene

SLC7A11 encodes a subunit of the xCT cystine/glutamate amino acid transport system and plays a critical role in the generation of glutathione and the protection of cells from oxidative stress. Expression of SLC7A11 promotes tumorigenesis and chemothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9794c70a1eecdb74787bc1b326f620f
http://europepmc.org/articles/PMC4433865

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