Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Leeni Koivisto"'
Autor:
Shuichiro Kobayashi, Jiarui Bi, Gethin Owen, Nelli Larjava, Leeni Koivisto, Lari Häkkinen, Hannu Larjava
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored. We hypothesiz
Externí odkaz:
https://doaj.org/article/d131ccc65e7446a497c70e5dbea6fea6
Autor:
Osamu Uehara, Jiarui Bi, Deshu Zhuang, Leeni Koivisto, Yoshihiro Abiko, Lari Häkkinen, Hannu Larjava
Publikováno v:
Journal of Oral Microbiology, Vol 14, Iss 1 (2022)
In periodontal disease (PD), bacterial biofilms suppress β6 integrin expression transforming growth factor-β1 signaling, resulting in gingival inflammation and bone loss. β6 integrin-null (Itgb6−/−) mice develop spontaneous PD. The aim of this
Externí odkaz:
https://doaj.org/article/2aeda8d8761b4c7c899b5c66c21633b8
Autor:
Jiarui Bi, Leeni Koivisto, Aihui Pang, Ming Li, Guoqiao Jiang, Saljae Aurora, Zhejun Wang, Gethin R. Owen, Jiayin Dai, Ya Shen, Daniel Grenier, Markus Haapasalo, Lari Häkkinen, Hannu Larjava
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Periodontal diseases manifest by the formation of deep pockets between the gingiva and teeth where multispecies bacterial biofilms flourish, causing inflammation and bone loss. Epithelial cell receptor αvβ6 integrin that regulates inflamma
Externí odkaz:
https://doaj.org/article/7122099892e944fca08d2c0010fd7dae
Akademický článek
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Autor:
Guoqiao Jiang, Hannu Larjava, Leeni Koivisto, Lari Häkkinen, Maria Fernanda Barona Intriago, Jiarui Bi
Publikováno v:
Journal of Clinical Periodontology. 47:851-862
Background Leucocyte- and platelet-rich fibrin (L-PRF) is a blood-derived biomaterial rich in leucocytes and platelets embedded in a high-density fibrin network that can be compressed into a membrane and used in surgical applications to stimulate tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10edf273bb14a35f17fadbd4f6f62301
https://doi.org/10.1111/jcpe.13293
https://doi.org/10.1111/jcpe.13293
Autor:
Shuichiro Kobayashi, Jiarui Bi, Gethin Owen, Nelli Larjava, Leeni Koivisto, Lari Häkkinen, Hannu Larjava
Publikováno v:
Scientific reports. 12(1)
Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored. We hypothesized that m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5b7a05a702c0f326cab978cf71adc0
https://pubmed.ncbi.nlm.nih.gov/36138045
https://pubmed.ncbi.nlm.nih.gov/36138045
Autor:
Colin Wiebe, Corrie L. Gallant-Behm, Dylan Olver, Leeni Koivisto, Hannu Larjava, Wesley Mah, David A. Hart, Guoqiao Jiang, Lari Häkkinen
Publikováno v:
The American Journal of Pathology. 187:1717-1735
Compared to skin, wound healing in oral mucosa is faster and produces less scarring, but the mechanisms involved are incompletely understood. Studies in mice have linked high expression of CD26 to a profibrotic fibroblast phenotype, but this has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d67b1913fa1153461de1a64f4da70c2
https://doi.org/10.1016/j.ajpath.2017.04.017
https://doi.org/10.1016/j.ajpath.2017.04.017
Autor:
Leeni Koivisto, Ya Shen, Milla Larjava, Liangjia Bi, Guoqiao Jiang, Fang Liu, Deshu Zhuang, Lari Häkkinen, Hannu Larjava, Jiayin Dai, Jiarui Bi, Markus Haapasalo
Publikováno v:
Journal of cell science. 133(5)
In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss. In healthy individuals, αvβ6 integrin in junctional epithelium maintains anti-inflammatory transforming growth factor-β1 (TGF-β1) signaling, wherea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b265640bc2b6e3dfb46cf69b0d8409b
https://pubmed.ncbi.nlm.nih.gov/31722981
https://pubmed.ncbi.nlm.nih.gov/31722981
Autor:
Gethin Rhys Owen, P. Huang, Liangjia Bi, Ya Shen, Jyrki Heino, Jiarui Bi, Leeni Koivisto, Anne Rokka, Zhejun Wang, Markus Haapasalo, Hannu Larjava, Lari Häkkinen
Publikováno v:
Journal of Dental Research. 95:680-688
Microvesicles (MVs) are extracellular vesicles secreted by various cell types that are involved in intercellular communication. We hypothesized that in human periodontal disease, the pocket epithelium releases MVs, which then modulate gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49a56ccc0789471c1db2000ac8fddc2
https://doi.org/10.1177/0022034516633172
https://doi.org/10.1177/0022034516633172
Publikováno v:
The international journal of biochemistrycell biology. 99
Integrins are cell surface receptors that traditionally mediate cell-to-extracellular matrix and cell-to-cell adhesion. They can, however, also bind a large repertoire of other molecules. Integrin αvβ6 is exclusively expressed in epithelial cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e792b87cd89d66cd1149879bda06e70b
https://pubmed.ncbi.nlm.nih.gov/29678785
https://pubmed.ncbi.nlm.nih.gov/29678785