Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Leendert W, Hamoen"'
Autor:
Declan A. Gray, Biwen Wang, Margareth Sidarta, Fabián A. Cornejo, Jurian Wijnheijmer, Rupa Rani, Pamela Gamba, Kürşad Turgay, Michaela Wenzel, Henrik Strahl, Leendert W. Hamoen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The bactericidal activity of several antibiotics partially relies on the production of reactive oxygen species (ROS), which is generally linked to enhanced respiration and requires the Fenton reaction. Bacterial persister cells, an important
Externí odkaz:
https://doaj.org/article/973560fd47384ef4942e73993a74b4e5
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 3 (2024)
ABSTRACTTo infer the biological meaning from transcriptome data, it is useful to focus on genes that are regulated by the same regulator, i.e., regulons. Unfortunately, current gene set enrichment analysis (GSEA) tools do not consider whether a gene
Externí odkaz:
https://doaj.org/article/8d0fe696dd0c42078aee2e187abaf35b
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background The bacterium Bacillus subtilis is extensively used for the commercial production of enzymes due to its efficient protein secretion capacity. However, the efficiency of secretion varies greatly between enzymes, and despite many ye
Externí odkaz:
https://doaj.org/article/93fbd73cf128402bb56c855b87b6baa2
Autor:
Laura C. Bohorquez, Joana de Sousa, Transito Garcia-Garcia, Gaurav Dugar, Biwen Wang, Martijs J. Jonker, Marie-Françoise Noirot-Gros, Michael Lalk, Leendert W. Hamoen
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT The conserved protein WhiA is present in most Gram-positive bacteria and plays a role in cell division. WhiA contains a DNA-binding motif and is a transcription regulator of the key cell division gene ftsZ in actinomycetes. In Bacillus subti
Externí odkaz:
https://doaj.org/article/78f70b4caa8d41dd9c440d10875e7969
Autor:
Xudong Ouyang, Jelmer Hoeksma, Ronnie J. M. Lubbers, Tjalling K. Siersma, Leendert W. Hamoen, Jeroen den Hertog
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Antimicrobial resistance is a major threat to human health. Basic knowledge of antimicrobial mechanism of action (MoA) is imperative for patient care and for identification of novel antimicrobials. However, the process of antimicrobial MoA i
Externí odkaz:
https://doaj.org/article/25b05b3697bc464cbd9cd8e56dc0f06d
Autor:
Michaela Wenzel, Marien P. Dekker, Biwen Wang, Maroeska J. Burggraaf, Wilbert Bitter, Jan R. T. van Weering, Leendert W. Hamoen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Wenzel et al. developed a flat embedding method for TEM, which increases the fraction of appropriately orientated cells per image, making it easier to quantify cell morphology. They find that tetracycline-treated B. subtilis shows membrane lesions an
Externí odkaz:
https://doaj.org/article/6891a8b700bc4b0d86ca8c303d7203c1
Autor:
Declan A. Gray, Gaurav Dugar, Pamela Gamba, Henrik Strahl, Martijs J. Jonker, Leendert W. Hamoen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Bacteria can become dormant or form spores when starved for nutrients. Here, Gray et al. describe an alternative strategy, or ‘oligotrophic growth state’, showing that non-sporulating Bacillus subtilis cells can survive deep starvation conditions
Externí odkaz:
https://doaj.org/article/133c12f4670a4ffe92c3389e4e2a75af
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract The conserved cell division protein SepF aligns polymers of FtsZ, the key cell division protein in bacteria, during synthesis of the (Fts)Z-ring at midcell, the first stage in cytokinesis. In addition, SepF acts as a membrane anchor for the
Externí odkaz:
https://doaj.org/article/569eec12e463423998eb20c4d829d865
Autor:
Terrens N. V. Saaki, Zihao Teng, Michaela Wenzel, Magali Ventroux, Rut Carballido‐Lόpez, Marie Francoise Noirot‐Gros, Leendert W. Hamoen
Publikováno v:
Molecular Microbiology, 117(5), 1263-1274. Wiley-Blackwell
In many bacteria, cell division begins before the sister chromosomes are fully segregated. Specific DNA translocases ensure that the chromosome is removed from the closing septum, such as the transmembrane protein FtsK in Escherichia coli. Bacillus s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22268ce8251fb5fd38592ffead92a56c
https://hdl.handle.net/11245.1/c792bea2-8777-4df2-8fe3-00914f062070
https://hdl.handle.net/11245.1/c792bea2-8777-4df2-8fe3-00914f062070
Publikováno v:
Nature genetics, 54. Nature Publishing Group
Nucleoprotein complexes play an integral role in genome organization of both eukaryotes and prokaryotes. Apart from their role in locally structuring and compacting DNA, several complexes are known to influence global organization by mediating long-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cf4f6b5c03c4ca42f53e9cd7218064
https://doi.org/10.1038/s41588-021-00988-8
https://doi.org/10.1038/s41588-021-00988-8