Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Leendert H.J. Looijenga"'
Autor:
Caroline C.C. Hulsker, Maya Schulpen, Annelies M.C. Mavinkurve-Groothuis, Otto Visser, József Zsiros, Marc H.W. Wijnen, Ronald R. de Krijger, Annette H. Bruggink, Leendert H.J. Looijenga, Henrike E. Karim-Kos, Alida F.W. van der Steeg
Publikováno v:
EJC Paediatric Oncology, Vol 3, Iss , Pp 100148- (2024)
Background: Population-based studies assessing long-term patterns of incidence and disease characteristics of germ cell tumors (GCTs) in children are scarce. We investigated incidence and survival trends of malignant extracranial GCTs in children usi
Externí odkaz:
https://doaj.org/article/3d2b227095c7475cb0180235ba227e31
Autor:
Michal Mego, Katarina Rejlekova, Daniela Svetlovska, Vera Miskovska, Ad J.M. Gillis, Valentina De Angelis, Katarina Kalavska, Jana Obertova, Patrik Palacka, Maria Reckova, Zuzana Sycova-Mila, Daniel Pindak, Michal Chovanec, Leendert H.J. Looijenga, Jozef Mardiak
Publikováno v:
European Urology Open Science, Vol 33, Iss , Pp 19-27 (2021)
Background: Germ cell tumors represent highly curable disease even in metastatic stage. However, poor-risk patients with an unfavorable serum tumor marker (STM) decline after the first cycle of chemotherapy represent a subgroup with dismal prognosis,
Externí odkaz:
https://doaj.org/article/d3c43bc015da42a092dcf78191b04e22
Autor:
Cezanne D. Kooij, Caroline C.C. Hulsker, Mariëtte E.G. Kranendonk, József Zsiros, Annemieke S. Littooij, Leendert H.J. Looijenga, Aart J. Klijn, Annelies M.C. Mavinkurve-Groothuis
Publikováno v:
Surgeries, Vol 2, Iss 1, Pp 9-19 (2021)
Aim: This study reports surgical treatment and its outcome for boys with a testicular tumor, in order to analyze the considerations of testis-sparing surgery (TSS) and investigate whether, in retrospect, treatment was according to a recently develope
Externí odkaz:
https://doaj.org/article/80ef7f923eb6468e89e74279a55ca702
Autor:
Daniela C.F. Salvatori, Lambert C.J. Dorssers, Ad J.M. Gillis, Gemma Perretta, Ton van Agthoven, Maria Gomes Fernandes, Hans Stoop, Jan-Bas Prins, J. Wolter Oosterhuis, Christine Mummery, Leendert H.J. Looijenga
Publikováno v:
Stem Cell Reports, Vol 11, Iss 6, Pp 1493-1505 (2018)
Summary: Predicting developmental potency and risk of posttransplantation tumor formation by human pluripotent stem cells (hPSCs) and their derivatives largely rely on classical histological analysis of teratomas. Here, we investigated whether an ass
Externí odkaz:
https://doaj.org/article/867f613e760548099acac7ca16f9da17
Autor:
Adone Mohd-Sarip, Miriam Teeuwssen, Alice G. Bot, Maria J. De Herdt, Stefan M. Willems, Robert J. Baatenburg de Jong, Leendert H.J. Looijenga, Diana Zatreanu, Karel Bezstarosti, Job van Riet, Edwin Oole, Wilfred F.J. van Ijcken, Harmen J.G. van de Werken, Jeroen A. Demmers, Riccardo Fodde, C. Peter Verrijzer
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 61-75 (2017)
The Nucleosome Remodeling and Deacetylase (NURD) complex is a key regulator of cell differentiation that has also been implicated in tumorigenesis. Loss of the NURD subunit Deleted in Oral Cancer 1 (DOC1) is associated with human oral squamous cell c
Externí odkaz:
https://doaj.org/article/388a23c8a0fc482fa04851442525be89
Autor:
Paul W. Schenk, Hans Stoop, Carsten Bokemeyer, Frank Mayer, Gerrit Stoter, J. Wolter Oosterhuis, Erik Wiemer, Leendert H.J. Looijenga, Kees Nooter
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 4, Pp 297-301 (2004)
Male germ cell tumors (GCTs) are extremely sensitive to platinum-containing chemotherapy, with only 10% of patients showing therapy resistance. However, the biological basis of the high curability of disseminated GCTs by chemotherapy is still unknown
Externí odkaz:
https://doaj.org/article/72cf020a20f24710ad08aec719857499
Autor:
James F. Amatruda, Dinesh Rakheja, Theodore W. Laetsch, Leendert H.J. Looijenga, Lawrence Lum, A. Lindsay Frazier, Payal Kapur, Kiyoshi Yamaguchi, Sarai H. Stuart, Christina Ateek, Albert Budhipramono, Emily K. Stroup, Abhay A. Shukla, Nicholas J. Fustino, Kenneth S. Chen
Germ cell tumors (GCT) are malignant tumors that arise from pluripotent embryonic germ cells and occur in children and young adults. GCTs are treated with cisplatin-based regimens which, while overall effective, fail to cure all patients and cause si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d02f346e8bfa5d168d6fbe51a99d23af
https://doi.org/10.1158/1535-7163.c.6538071.v1
https://doi.org/10.1158/1535-7163.c.6538071.v1
Autor:
Dennis M. Timmerman, Thomas F. Eleveld, Sruthi Sriram, Lambert C.J. Dorssers, Ad J.M. Gillis, Silvia Schmidtova, Katarina Kalavska, Harmen J.G. van de Werken, Christoph Oing, Friedemann Honecker, Michal Mego, Leendert H.J. Looijenga
Publikováno v:
Journal of Clinical Oncology, 118(26):JCO.21.02809, 3077-3087. American Society of Clinical Oncology
PURPOSE Cisplatin is the main systemic treatment modality for male type II germ cell tumors (GCTs). Although generally very effective, 5%-10% of patients suffer from cisplatin-resistant disease. Identification of the driving mechanisms of resistance
Autor:
Jw Oosterhuis, Leendert H.J. Looijenga
Publikováno v:
Reference Module in Biomedical Sciences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9b53b3ff7a96acb92392a470c1bae0
https://doi.org/10.1016/b978-0-12-801238-3.66150-0
https://doi.org/10.1016/b978-0-12-801238-3.66150-0
Autor:
Lorraine Robb, Marilyn Ibrahim, Leendert H.J. Looijenga, Chung Wo Chow, Adam H. Hart, Lynne Hartley, Karen M. Parker, Marija Pauchnik
Publikováno v:
Cancer. 104:2092-2098
BACKGROUND The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-