Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Leendert H. J. Looijenga"'
Autor:
Ferdinand W. Janssen, Nathalie S. M. Lak, Claudia Y. Janda, Lennart A. Kester, Michael T. Meister, Johannes H. M. Merks, Marry M. van den Heuvel-Eibrink, Max M. van Noesel, Jozsef Zsiros, Godelieve A. M. Tytgat, Leendert H. J. Looijenga
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-25 (2024)
Abstract Liquid biopsies are emerging as an alternative source for pediatric cancer biomarkers with potential applications during all stages of patient care, from diagnosis to long-term follow-up. While developments within this field are reported, th
Externí odkaz:
https://doaj.org/article/7e228ee58b924504a47bb48758ddcf6e
Autor:
Sruthi Sriram, Tiago Macedo, Annelies Mavinkurve‐Groothuis, Marianne van deWetering, Leendert H. J. Looijenga
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 7, Pp n/a-n/a (2024)
Abstract Rising cure rates in pediatric cancer patients warrants an increased attention toward the long‐term consequences of the diagnosis and treatment in survivors. Chemotherapeutic agents can be gonadotoxic, rendering them at risk for infertilit
Externí odkaz:
https://doaj.org/article/6363f12c5da5476cb9855c8efc0244c7
Autor:
Lin Xu, Joshua L. Pierce, Angelica Sanchez, Kenneth S. Chen, Abhay A. Shukla, Nicholas J. Fustino, Sarai H. Stuart, Aditya Bagrodia, Xue Xiao, Lei Guo, Mark D. Krailo, Furqan Shaikh, Deborah F. Billmire, Farzana Pashankar, Jessica Bestrashniy, J. Wolter Oosterhuis, Ad J. M. Gillis, Yang Xie, Lisa Teot, Jaume Mora, Jenny N. Poynter, Dinesh Rakheja, Leendert H. J. Looijenga, Bruce W. Draper, A. Lindsay Frazier, James F. Amatruda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Germ cell tumors (GCTs) are neoplasms of the testis, ovary and extragonadal sites that occur in infants, children, adolescents and adults. Post-pubertal (type II) malignant GCTs may present as seminoma, non-seminoma or mixed histologies. In
Externí odkaz:
https://doaj.org/article/7de0ec00eddb4344af90c7a9512816da
Autor:
Francis S. P. L. Wens, Caroline C. C. Hulsker, Marta Fiocco, József Zsiros, Stephanie E. Smetsers, Ronald R. de Krijger, Alida F. W. van der Steeg, Ronald P. Zweemer, Inge O. Baas, Eva Maria Roes, Leendert H. J. Looijenga, Cornelis G. Gerestein, Annelies M. C. Mavinkurve-Groothuis
Publikováno v:
Cancers, Vol 15, Iss 15, p 3794 (2023)
Background: Small-cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare aggressive ovarian malignancy mainly affecting children, adolescents, and young adults. Since the discovery of mutations in the SMARCA4 gene in 2014, SCCOHT has beco
Externí odkaz:
https://doaj.org/article/d21599d3da59460aa268e0f1502c3451
Autor:
Vera Miranda-Gonçalves, João Lobo, Catarina Guimarães-Teixeira, Daniela Barros-Silva, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Christoph Oing, Friedemann Honecker, Daniel Nettersheim, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
Abstract Background Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ cell development. The recent and expanding field of RNA modifications is being increasingly implicated in such molecular events, as well a
Externí odkaz:
https://doaj.org/article/a7363cbfa25843038c4292ef51b2d603
Autor:
João Lobo, Vera Constâncio, Catarina Guimarães‐Teixeira, Pedro Leite‐Silva, Vera Miranda‐Gonçalves, José Pedro Sequeira, Laura Pistoni, Rita Guimarães, Mariana Cantante, Isaac Braga, Joaquina Maurício, Leendert H. J. Looijenga, Rui Henrique, Carmen Jerónimo
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 846-865 (2021)
Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit side effects of chemotherap
Externí odkaz:
https://doaj.org/article/52fde9c1694a4ab4be5da24a6b2b8d6b
Publikováno v:
Cancer Medicine, Vol 10, Iss 8, Pp 2897-2903 (2021)
Abstract Background To determine, using testicular germ cell cancer screening as an example, whether screening can also be effective for cancers with a good prognosis. Methods Based on the Dutch incidence, stage distribution, and survival and mortali
Externí odkaz:
https://doaj.org/article/b7d3756d0a3648ba98fe046848cd4b85
Autor:
Joaquin Montilla-Rojo, Monika Bialecka, Kimberley E. Wever, Christine L. Mummery, Leendert H. J. Looijenga, Bernard A. J. Roelen, Daniela C. F. Salvatori
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3879 (2023)
Pluripotency describes the ability of stem cells to differentiate into derivatives of the three germ layers. In reporting new human pluripotent stem cell lines, their clonal derivatives or the safety of differentiated derivatives for transplantation,
Externí odkaz:
https://doaj.org/article/8a54886de89e48a6b308d2be90296a15
Autor:
Jobran M. Moshi, Klaas J. Hoogduin, Monique Ummelen, Mieke E. R. Henfling, Manon vanEngeland, Kim A. D. Wouters, Hans Stoop, Imke Demers, Leendert H. J. Looijenga, Frans C. S. Ramaekers, Anton N. H. Hopman
Publikováno v:
Cancer Medicine, Vol 9, Iss 17, Pp 6330-6343 (2020)
Abstract Aims The dynamics and topographical distribution of SOX17 and SOX2 expression was studied in the transformation zone (TZ) of the uterine cervix. This TZ is a dynamic area where switches from glandular into squamous epithelium can be recogniz
Externí odkaz:
https://doaj.org/article/48b7637d65e54d66b12f87f63287acfd
Autor:
Silvia Schmidtova, Lambert C. J. Dorssers, Katarina Kalavska, Ad J. M. Gillis, J. Wolter Oosterhuis, Hans Stoop, Svetlana Miklikova, Zuzana Kozovska, Monika Burikova, Katarina Gercakova, Erika Durinikova, Michal Chovanec, Michal Mego, Lucia Kucerova, Leendert H. J. Looijenga
Publikováno v:
Cancer Cell International, Vol 20, Iss 1, Pp 1-16 (2020)
Abstract Background Cisplatin resistance of ovarian yolk sac tumors (oYST) is a clinical challenge due to dismal patient prognosis, even though the disease is extremely rare. We investigated potential association between cisplatin resistance and canc
Externí odkaz:
https://doaj.org/article/258316cd46dd400db76dfc03e396edbd