Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leena Saikko"'
Autor:
Lan Zhao, Shuyuan Wang, Marit Ilves, Sanna Lehtonen, Leena Saikko, Hani El-Nezami, Harri Alenius, Piia Karisola
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5183 (2023)
Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μg of nZnO
Externí odkaz:
https://doaj.org/article/306b81a74a5e48ebb24f5891be21e0cc
Autor:
Olli Dufva, Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran, Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh Ko, Won Seog Kim, Shih-Sung Chuang, Tero Aittokallio, Wing C. Chan, Koichi Ohshima, Fumihiro Ishida, Satu Mustjoki
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-S
Externí odkaz:
https://doaj.org/article/a90516e221ea4f0c9791e1e130cc3ead
Autor:
Emma I. Andersson, Oscar Brück, Till Braun, Susanna Mannisto, Leena Saikko, Sonja Lagström, Pekka Ellonen, Sirpa Leppä, Marco Herling, Panu E. Kovanen, Satu Mustjoki
Publikováno v:
Cancers, Vol 12, Iss 3, p 702 (2020)
Peripheral T-cell lymphomas (PTCL) are a heterogeneous, and often aggressive group of non-Hodgkin lymphomas. Recent advances in the molecular and genetic characterization of PTCLs have helped to delineate differences and similarities between the vari
Externí odkaz:
https://doaj.org/article/f2d03ed5e20842c1a6801994ad880456
Autor:
Claudia Filippone, Rauli Franssila, Arun Kumar, Leena Saikko, Panu E Kovanen, Maria Söderlund-Venermo, Klaus Hedman
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9496 (2010)
BACKGROUND: Continued development of in-vitro procedures for expansion and differentiation of erythroid progenitor cells (EPC) is essential not only in hematology and stem cell research but also virology, in light of the strict erythrotropism of the
Externí odkaz:
https://doaj.org/article/ab56d1eddac6402e8be74c70470d56df
Autor:
Satu Mustjoki, Francis Y.F. Lee, Kimmo Porkka, Panu E. Kovanen, Akseli Hemminki, Leena Saikko, Siri Tähtinen, Paula Savola, Markus Vähä-Koskela, Richard Smykla, Erin Michaud, Jun Yan, Mette Ilander, Can Hekim
Supplementary Figure S1. Dasatinib-induced rapid lymphocyte mobilization and tumor growth rate correlation Supplementary Figure S2. Immunohistochemical staining of CD8+ T cells in the tumor tissues of A) vehicle treated control group and B) dasatinib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61dbd4a204cf319008e6f53370ac729
https://doi.org/10.1158/2326-6066.22537601
https://doi.org/10.1158/2326-6066.22537601
Autor:
Satu Mustjoki, Francis Y.F. Lee, Kimmo Porkka, Panu E. Kovanen, Akseli Hemminki, Leena Saikko, Siri Tähtinen, Paula Savola, Markus Vähä-Koskela, Richard Smykla, Erin Michaud, Jun Yan, Mette Ilander, Can Hekim
Dasatinib, a broad-range tyrosine kinase inhibitor, induces rapid mobilization of lymphocytes and clonal expansion of cytotoxic cells in leukemia patients. Here, we investigated whether dasatinib could induce beneficial immunomodulatory effects in so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d227dfbe88af5b297188037bd5ef6c
https://doi.org/10.1158/2326-6066.c.6548492.v1
https://doi.org/10.1158/2326-6066.c.6548492.v1
Autor:
Satu Mustjoki, Bhagwan Yadav, Young Hyeh Ko, Samuli Eldfors, Emma I. Andersson, Koichi Ohshima, Panu E. Kovanen, Disha Malani, Olli Dufva, Hideyuki Nakazawa, Paavo Pietarinen, Nodoka Sekiguchi, Leena Saikko, Junji Suzumiya, Thomas P. Loughran, Matti Kankainen, Ritsuro Suzuki, Dean A. Lee, Wing C. Chan, Heikki Kuusanmäki, Shih-Sung Chuang, Teija Ojala, Shady Adnan Awad, Fumihiro Ishida, Won Seog Kim, Tiina Kelkka, Tero Aittokallio
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
Aggressive natural killer-cell (NK-cell) leukemia (ANKL) is an extremely aggressive malignancy with dismal prognosis and lack of targeted therapies. Here, we elucidate the molecular pathogenesis of ANKL using a combination of genomic and drug sensiti
Autor:
Kimmo Porkka, Akseli Hemminki, Satu Mustjoki, Jun Yan, Richard Smykla, Francis Y. Lee, Markus Vähä-Koskela, Mette Ilander, Siri Tähtinen, Can Hekim, Leena Saikko, Paula Savola, Panu E. Kovanen, Erin Michaud
Publikováno v:
Cancer immunology research. 5(2)
Dasatinib, a broad-range tyrosine kinase inhibitor, induces rapid mobilization of lymphocytes and clonal expansion of cytotoxic cells in leukemia patients. Here, we investigated whether dasatinib could induce beneficial immunomodulatory effects in so
Autor:
Satu Mustjoki, Young Hyeh Ko, Shady Adnan Awad, Heikki Kuusanmäki, Shih-Sung Chuang, Fumihiro Ishida, Wing C. Chan, Leena Saikko, Tiina Kelkka, Junji Suzumiya, Nodoka Sekiguchi, Won Seog Kim, Disha Malani, Paavo Pietarinen, Thomas P. Loughran, Emma I. Andersson, Olli Dufva, Samuli Eldfors, Koichi Ohshima, Panu E. Kovanen
Publikováno v:
Blood. 126:700-700
Background Natural killer (NK) cell malignancies are rare lymphoid neoplasms characterized by aggressive clinical behavior and poor treatment outcomes. Clinically they are classified as extranodal NK/T-cell lymphoma, nasal type (NKTCL) and aggressive
Autor:
Satu Mustjoki, Markus Vähä-Koskela, Kimmo Porkka, Panu E. Kovanen, Mette Ilander, Leena Saikko, Siri Tähtinen, Can Hekim, Paula Savola, Akseli Hemminki
Publikováno v:
Blood. 124:1408-1408
Background: Dasatinib is a 2nd generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML). Its kinase inhibition profile is broad and includes several kinases important in the immune cell function such as SRC k