Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old

Autor: Raj N. Kalaria, Tuomo Polvikoski, Raimo Sulkava, Frederik Barkhof, P. Scheltens, Leena Niinistö, Hannu J. Aronen, Timo Erkinjuntti, Minna Oinas, E.C.W. van Straaten

Publikováno v: University of Helsinki
Neurology, 75(23), 2071-2078. Lippincott Williams and Wilkins
Polvikoski, T M, van Straaten, E C W, Barkhof, F, Sulkava, R, Aronen, H J, Niinisto, L, Oinas, M, Scheltens, P, Erkinjuntti, T & Kalaria, R N 2010, ' Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old ', Neurology, vol. 75, no. 23, pp. 2071-2078 . https://doi.org/10.1212/WNL.0b013e318200d6f9

Background: Current studies suggest an interaction between vascular mechanisms and neurodegenerative processes that leads to late-onset Alzheimer disease (AD). We tested whether AD pathology was associated with white matter hyperintensities (WMH) or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd39c5d0f75c974b9ec175b8c91d7965
https://doi.org/10.1212/wnl.0b013e318200d6f9

Neuropathologic Findings of Dementia with Lewy Bodies (DLB) in a Population-based Vantaa 85+ Study

Autor: Irma-Leena Notkola, Tuomo Polvikoski, Sari Rastas, Raimo Sulkava, Kati Juva, Hannu Kalimo, Anders Paetau, Liisa Myllykangas, Minna Oinas, Leena Niinistö

Publikováno v: Journal of Alzheimer's Disease. 18:677-689

The consortium on dementia with Lewy bodies has established consensus guidelines for the neuropathologic diagnosis of dementia with Lewy bodies (DLB) including the likelihood that the neuropathologic findings associate with the clinical syndrome. Nev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e339c6d5479fa89a722d16f2608189
https://doi.org/10.3233/jad-2009-1169

Neurofibrillary tau pathology modulated by genetic variation of α-synuclein

Autor: Andrew B. Singleton, Tuomo Polvikoski, Anders Paetau, John Hardy, Leena Niinistö, Pentti J. Tienari, Raimo Sulkava, Hannu Kalimo, Terhi Peuralinna, Dena G. Hernandez, Liisa Myllykangas, Minna Oinas

Publikováno v: Annals of Neurology. 64:348-352

We analyzed whether genetic variation of alpha-synuclein modulates the extent of neuropathological changes in a population-based autopsied sample of 272 elderly Finns. None of the 11 markers was associated with the extent of neocortical beta-amyloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fde6466264df6b8817d4cb7454e83d2d
https://doi.org/10.1002/ana.21446

Incidence of Dementia in Very Elderly Individuals: A Clinical, Neuropathological and Molecular Genetic Study

Autor: Matti Haltia, Auli Verkkoniemi, Kati Juva, Annamaija Sutela, Sari Rastas, Leena Niinistö, Tuomo Polvikoski, Irma-Leena Notkola, Raimo Sulkava, Petteri Viramo

Publikováno v: Neuroepidemiology. 26:76-82

Aims: To evaluate the effect of medical record use on figures for the incidence of dementia and the effect of apolipoprotein E (APOE) polymorphism on this incidence and neuropathologically defined Alzheimer’s disease (AD) in very elderly individual

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560b93fe3dffed541be70093c2056e99
https://doi.org/10.1159/000090252

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Autor: Leena Niinistö, Kati Juva, Raimo Sulkava, Auli Verkkoniemi

Publikováno v: Journal of Clinical Geropsychology. 7:39-45

We examined 553 persons aged 85 years or more, who comprised 92% of all 601 citizens of a Finnish city Vantaa. The Mini-Mental State Examination (MMSE), Index of Activities of Daily Living (ADL), and the Instrumental Activities of Daily Living (IADL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f39c90895ce15dc9c35ed1ccf30007d8
https://doi.org/10.1023/a:1026412701660