Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Leena Maddukuri"'
Autor:
Megan R. Reed, A. Geoffrey Lyle, Annick De Loose, Leena Maddukuri, Katrina Learned, Holly C. Beale, Ellen T. Kephart, Allison Cheney, Anouk van den Bout, Madison P. Lee, Kelsey N. Hundley, Ashley M. Smith, Teresa M. DesRochers, Cecile Rose T. Vibat, Murat Gokden, Sofie Salama, Christopher P. Wardell, Robert L. Eoff, Olena M. Vaske, Analiz Rodriguez
Publikováno v:
Cells, Vol 10, Iss 12, p 3400 (2021)
Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by germline mutations in TP53. TP53 is the most common mutated gene in human cancer, occurring in 30–50% of glioblastomas (GBM). Here, we highlight a precision medicin
Externí odkaz:
https://doaj.org/article/9dc85f09d7834fddbaa84d2a1a8e9843
Autor:
Justin W.C. Leung, Jessica H. Hartman, Makayla Berry, Robert L. Eoff, Lane Smith, Alyssa Richey, Julie Gunderson, Leena Maddukuri, Callie Johnson, Megan R. Reed, Amit Ketkar
Publikováno v:
Nucleic Acids Research
We previously reported that human Rev1 (hRev1) bound to a parallel-stranded G-quadruplex (G4) from the c-MYC promoter with high affinity. We have extended those results to include other G4 motifs, finding that hRev1 exhibited stronger affinity for pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c08dd83219609f6a81157da30073a87
http://europepmc.org/articles/PMC7913688
http://europepmc.org/articles/PMC7913688
Autor:
Narsimha Reddy Penthala, Amit Ketkar, Peter A. Crooks, Maroof K. Zafar, Leena Maddukuri, Robert L. Eoff, Megan R. Reed
Publikováno v:
ACS Chem Biol
Overexpression of human DNA polymerase kappa (hpol κ) in glioblastoma is associated with shorter survival time and resistance to the alkylating agent temozolomide (TMZ), making it an attractive target for the development of small-molecule inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26018f3e9d3838c0e9c18de7d9702ef6
https://doi.org/10.1021/acschembio.9b00304
https://doi.org/10.1021/acschembio.9b00304
Autor:
Robert L. Eoff, Justin W.C. Leung, Maroof K. Zafar, Amit Ketkar, Analiz Rodriguez, Megan R. Reed, Leena Maddukuri
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5135b1063f38eb6806bfcdb84747814b
https://doi.org/10.1096/fasebj.2021.35.s1.03041
https://doi.org/10.1096/fasebj.2021.35.s1.03041
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8495ef04b8f98f1e24ce8e13d8e872b
https://doi.org/10.1096/fasebj.2021.35.s1.02971
https://doi.org/10.1096/fasebj.2021.35.s1.02971
Autor:
Jessica Hartman, Amit Ketkar, Alyssa Richey, Megan Reed, Lane Smith, Julie Gunderson, Leena Maddukuri, Robert L. Eoff, Makayla Berry, Justin W.C. Leung, Callie Johnson
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43eb87c39b0362f5a2d575e0f28c9b93
https://doi.org/10.1096/fasebj.2021.35.s1.02319
https://doi.org/10.1096/fasebj.2021.35.s1.02319
Autor:
Maroof K. Zafar, Leena Maddukuri, Robert L. Eoff, Amit Ketkar, Stephanie D. Byrum, Alan J. Tackett, April C.L. Bostian, Megan R. Reed
Publikováno v:
Nar Cancer
Expression of tryptophan 2,3-dioxygenase (TDO) is a determinant of malignancy in gliomas through kynurenine (KYN) signaling. We report that inhibition of TDO activity attenuated recovery from replication stress and increased the genotoxic effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b6a536ca8038d6c8cc55a6c11f9dbc
https://doi.org/10.1101/2020.05.28.110874
https://doi.org/10.1101/2020.05.28.110874
Autor:
Megan R. Reed, Robert L. Eoff, Narsimha Reddy Penthala, Leena Maddukuri, Peter A. Crooks, Maroof K. Zafar, Sarah Eddy, Amit Ketkar
Publikováno v:
Biochemistry
Translesion DNA synthesis (TLS) performed by human DNA polymerase eta (hpol η) allows tolerance of damage from cis-diamminedichloroplatinum(II) (CDDP or cisplatin). We have developed hpol η inhibitors derived from N-aryl-substituted indole barbitur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4734c01ca96f549f43ec9e06fdf89e
https://doi.org/10.1021/acs.biochem.7b01176
https://doi.org/10.1021/acs.biochem.7b01176
Autor:
Christopher P. Wardell, Robert L. Eoff, Annick De Loose, Sofie R. Salama, Anouk van den Bout, Teresa M. DesRochers, A. Geoffrey Lyle, Murat Gokden, Madison P Lee, Kelsey Hundley, Analiz Rodriguez, Allison Cheney, Katrina Learned, Leena Maddukuri, Olena M. Vaske, Megan R. Reed, Holly C. Beale, Cecile Rose T. Vibat, Ashley M. Smith, Ellen Kephart
Publikováno v:
Cells, Vol 10, Iss 3400, p 3400 (2021)
Cells
Cells; Volume 10; Issue 12; Pages: 3400
Cells
Cells; Volume 10; Issue 12; Pages: 3400
Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by germline mutations in TP53. TP53 is the most common mutated gene in human cancer, occurring in 30–50% of glioblastomas (GBM). Here, we highlight a precision medicin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f35e9765ca24ba4181d07b0b2ccd621
https://doi.org/10.3390/cells10123400
https://doi.org/10.3390/cells10123400
Publikováno v:
Biochemistry. 55:5218-5229
We have investigated the in vitro properties of human Y-family polymerase κ (hpol κ) on G-quadruplex DNA (G4 DNA). Similar to hpol η, another Y-family member implicated in replication of G4 motifs, hpol κ bound G4 DNA with a 5.7-fold preference o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa43d59785aeef03cef5250911be723
https://doi.org/10.1021/acs.biochem.6b00374
https://doi.org/10.1021/acs.biochem.6b00374