Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Leena Hilakivi‐Clarke"'
Publikováno v:
Cancer Reports, Vol 5, Iss 12, Pp n/a-n/a (2022)
Abstract Background About 50 000 new cases of cancer in the United States are attributed to obesity. The adverse effects of obesity on breast cancer may be most profound when affecting the early development; that is, in the womb of a pregnant obese m
Externí odkaz:
https://doaj.org/article/2645d0002dcf485c9334b7128bb20ca7
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background ChIP-seq combines chromatin immunoprecipitation assays with sequencing and identifies genome-wide binding sites for DNA binding proteins. While many binding sites have strong ChIP-seq ‘peak’ observations and are well captured,
Externí odkaz:
https://doaj.org/article/7af3fa2ac7bb4e6599bc5d30b839504e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Exploring complex modularization of intracellular signal transduction pathways is critical to understanding aberrant cellular responses during disease development and drug treatment. IMPALA (Inferred Modularization of PAthway LAndscapes) int
Externí odkaz:
https://doaj.org/article/32d612ab2fdb4044b1d63cf35aeb622a
Autor:
Fabia de Oliveira Andrade, Lu Jin, Robert Clarke, Imani Wood, MaryAnn Dutton, Chezaray Anjorin, Grace Rubin, Audrey Gao, Surojeet Sengupta, Kevin FitzGerald, Leena Hilakivi-Clarke
Publikováno v:
Cells, Vol 12, Iss 6, p 961 (2023)
Although multifactorial in origin, one of the most impactful consequences of social isolation is an increase in breast cancer mortality. How this happens is unknown, but many studies have shown that social isolation increases circulating inflammatory
Externí odkaz:
https://doaj.org/article/6c0ca74964b34fddba43f3f77a7b7c77
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 7, p e1009203 (2021)
Transcription factors (TFs) often function as a module including both master factors and mediators binding at cis-regulatory regions to modulate nearby gene transcription. ChIP-seq profiling of multiple TFs makes it feasible to infer functional TF mo
Externí odkaz:
https://doaj.org/article/8dab73ad1e7f4e9e9a60c5ae09697eda
Autor:
Nguyen M. Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M. Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis, Leena Hilakivi-Clarke
Publikováno v:
Breast Cancer Research, Vol 19, Iss 1, Pp 1-13 (2017)
Abstract Background Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primor
Externí odkaz:
https://doaj.org/article/dbe31791a3c543a396728f625039585b
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170482 (2017)
One of the important tasks in cancer research is to identify biomarkers and build classification models for clinical outcome prediction. In this paper, we develop a CyNetSVM software package, implemented in Java and integrated with Cytoscape as an ap
Externí odkaz:
https://doaj.org/article/bbd33f947e7e48979061f44e6a0882ce
Publikováno v:
Journal of Pregnancy, Vol 2013 (2013)
Externí odkaz:
https://doaj.org/article/00a457f4bcbf4a43825956c52e86a5b9
Autor:
Maryann Kwa, Marc Schwartz, Katherine D. Crew, Jeanine M. Genkinger, Roger L. Brown, Leena Hilakivi-Clarke, Joanna Kitlinska, Douglas W. Roblin, Michael Antoni, Sylvia Adams, Kathie-Ann Joseph, Lei-Shih Chen, Judy Huei-yu Wang
Publikováno v:
Cancer Research. 83:OT3-14
Background: Socioeconomically disadvantaged and immigrant cancer survivors account for a significant and growing proportion of the breast cancer population in the US. Research on symptom burden and control among Chinese American (CA) breast cancer su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020fe99655e25039419f7558250ae6a2
https://doi.org/10.1158/1538-7445.sabcs22-ot3-14-01
https://doi.org/10.1158/1538-7445.sabcs22-ot3-14-01
Autor:
Fabia de Oliveira Andrade, Vivek Verma, Ester Molina Hoyo, Karla Andrade de Oliveira, Pal Koak, Lu Jin, Leena Hilakivi-Clarke
Publikováno v:
Cancer Research. 83:P3-06
Although immune checkpoint blockers (ICBs) have revolutionized the treatment of many cancers, only less than 30% of patients respond to any ICB as a monotherapy. Estrogens, produced by the adipose tissue in the mammary glands, are immunomodulators in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f09210c40cab537cc1205c2e15dde07
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-05
https://doi.org/10.1158/1538-7445.sabcs22-p3-06-05