Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Leena E, Viiri"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Metabolic dysfunction, partly driven by altered liver function, predisposes to coronary artery disease (CAD), but the role of liver in vulnerable atherosclerotic plaque development remains unclear. Here we produced hepatocyte-like cells (HLC
Externí odkaz:
https://doaj.org/article/a59d60494e114422b480f9913979936d
Autor:
Siiri Suominen, Tinja Hyypijev, Mari Venäläinen, Alma Yrjänäinen, Hanna Vuorenpää, Mari Lehti-Polojärvi, Mikko Räsänen, Aku Seppänen, Jari Hyttinen, Susanna Miettinen, Katriina Aalto-Setälä, Leena E. Viiri
Publikováno v:
Cells, Vol 12, Iss 19, p 2368 (2023)
Induced pluripotent stem cell (iPSC) technology enables differentiation of human hepatocytes or hepatocyte-like cells (iPSC-HLCs). Advances in 3D culturing platforms enable the development of more in vivo-like liver models that recapitulate the compl
Externí odkaz:
https://doaj.org/article/c56c0b0a36cf45aeabc88d46db5d20d7
Autor:
Iris D. Zelnik, Giora Volpert, Leena E. Viiri, Dimple Kauhanen, Tamar Arazi, Katriina Aalto-Setälä, Reijo Laaksonen, Anthony H. Futerman
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 10, Pp 1341-1346 (2020)
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has im
Externí odkaz:
https://doaj.org/article/304856de0b1d4bf49da64840fc81f255
Autor:
Mostafa Kiamehr, Leena E. Viiri, Terhi Vihervaara, Kaisa M. Koistinen, Mika Hilvo, Kim Ekroos, Reijo Käkelä, Katriina Aalto-Setälä
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1141-1153 (2017)
Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem cells (iPSCs) offer an alternative model to primary human hepatocytes to study lipid aberrations. However, the detailed lipid profile of HLCs is yet unknown. In the curre
Externí odkaz:
https://doaj.org/article/27d75dac246b442ab173278a2d2822ef
Autor:
Leena E. Viiri, Olli T. Raitakari, Heini Huhtala, Mika Kaähoänen, Riikka Rontu, Markus Juonala, Nina Hutri-Kaähoänen, Jukka Marniemi, Jorma S.A. Viikari, Pekka J. Karhunen, Terho Lehtimaäki
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 6, Pp 1298-1306 (2006)
The common apolipoprotein E (apoE) gene (APOE) ɛ2/ɛ3/ɛ4 polymorphism explains part of serum lipid variation, and polymorphisms in the APOE promoter region have been proposed to participate in the regulation of serum lipid levels within the most co
Externí odkaz:
https://doaj.org/article/fff1b391f2284d4698cd22c83c5c81e7
Publikováno v:
Clinical Epigenetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::6a3090338105f563198feef542b1e4af
Autor:
Dimple Kauhanen, Iris D. Zelnik, Tamar Arazi, Anthony H. Futerman, Reijo Laaksonen, Katriina Aalto-Setälä, Leena E. Viiri, Giora Volpert
Publikováno v:
J Lipid Res
Journal of Lipid Research, Vol 61, Iss 10, Pp 1341-1346 (2020)
Journal of Lipid Research, Vol 61, Iss 10, Pp 1341-1346 (2020)
The backbone of all sphingolipids (SLs) is a sphingoid long-chain base (LCB) to which a fatty acid is N-acylated. Considerable variability exists in the chain length and degree of saturation of both of these hydrophobic chains, and recent work has im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bab769d820b01d98f1c623f106c0a5
https://trepo.tuni.fi/handle/10024/127940
https://trepo.tuni.fi/handle/10024/127940
Autor:
Dimple Kauhanen, Leena E. Viiri, Kim Ekroos, Mostafa Kiamehr, Laura Heiskanen, Reijo Käkelä, Anna Alexanova, Reijo Laaksonen, Terhi Vihervaara, Katriina Aalto-Setälä
Publikováno v:
Journal of Cellular Physiology. 234:3744-3761
Hepatocyte-like cells (HLCs) differentiated from human-induced pluripotent stem cells offer an alternative platform to primary human hepatocytes (PHHs) for studying the lipid metabolism of the liver. However, despite their great potential, the lipid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84016418a56bb534150cd6f882dca077
https://doi.org/10.1002/jcp.27131
https://doi.org/10.1002/jcp.27131
Publikováno v:
Atherosclerosis. 331:e220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ada68a234906e84e575236d16d4c21
https://doi.org/10.1016/j.atherosclerosis.2021.06.675
https://doi.org/10.1016/j.atherosclerosis.2021.06.675
Autor:
Henri Niskanen, Mikko Oittinen, Tommi Rantapero, Minna U. Kaikkonen, Keijo Viiri, Leena E. Viiri, Katriina Aalto-Setälä, Anna Alexanova, Matti Nykter, Mostafa Kiamehr
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Hepatocyte-like cells (HLCs) derived from induced pluripotent stem cells (iPSCs) provide a renewable source of cells for drug discovery, disease modelling and cell-based therapies. Here, by using GRO-Seq we provide the first genome-wide analysis of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea73c25b864e2c8a8d4ffd1821d72b7a