Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leena Bhoite"'
Autor:
Andrew Gassman, Le T Hao, Leena Bhoite, Chad L Bradford, Chi-Bin Chien, Christine E Beattie, John P Manfredi
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74325 (2013)
Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions th
Externí odkaz:
https://doaj.org/article/f2dc9b0fc7754f7dbb55418140232e0b
Autor:
Paul M. Slattum, J. Adam Willardsen, Weston R Judd, Brita Brown, Liwen Huang, Daniel Wettstein, Kirill Ostanin, Khanh C. Hoang, Glen L Alberts, Bruce D. Roth, Burt Richards, Liisa Valppu, Leena Bhoite
Publikováno v:
Journal of Medicinal Chemistry. 54:5031-5047
A series of tetrahydropyranyl (THP) derivatives has been developed as potent inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) for use as anticancer agents. Structural modification of the submicromolar hit compound 3 led to the potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976862bd8e54e7b1fd5eabc0fd38a7e7
https://doi.org/10.1021/jm200249a
https://doi.org/10.1021/jm200249a
Publikováno v:
Molecular and Cellular Biology. 23:1910-1921
Transcriptional activation of the yeast HO gene involves the sequential action of DNA-binding and chromatin-modifying factors. Here we examine the role of the SAGA complex and the Nhp6 architectural transcription factor in HO regulation. Our data sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31410eacc1573d346d237cee6ed4e657
https://doi.org/10.1128/mcb.23.6.1910-1921.2003
https://doi.org/10.1128/mcb.23.6.1910-1921.2003
Autor:
Yaxin Yu, David J. Stillman, Yiyou Chen, Deborah W. Neklason, Robert M. Brazas, Michael D. Murphy, Leena Bhoite
Publikováno v:
Journal of Biological Chemistry. 270:29151-29161
SW15 encodes a zinc finger DNA binding protein required for the transcription of the Saccharomyces cerevisiae HO gene, and PHO2 encodes a homeodomain DNA binding protein. In vitro biochemical studies using purified Swi5p and Pho2p proteins have demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d921a6211ae12a84afbdf0d906daf98c
https://doi.org/10.1074/jbc.270.49.29151
https://doi.org/10.1074/jbc.270.49.29151
Autor:
Harry Austin, Kirill Ostanin, Leena Bhoite, Matthew D. Reeder, Kazuyuki Suzuki, Jeffrey W. Lockman, J. Adam Willardsen, Ryan Hoff, Vijay Baichwal
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
Several series of thieno[2-3-b]pyridine analogues were synthesized and screened for inhibitory activity against eukaryotic elongation factor-2 kinase (eEF2-K). Modifications around several regions of the lead molecules were made, with a ring fusion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363e0f2a1c0e59dffd146a427d6894dd
https://pubmed.ncbi.nlm.nih.gov/20189382
https://pubmed.ncbi.nlm.nih.gov/20189382
Autor:
Lance R. Thomas, Warren P. Voth, Emily Garcia, Ronda J. Rolfes, Leena Bhoite, I. David Gregory, Kristen Whelihan, Jason M. Allen, David J. Stillman
Publikováno v:
The Journal of biological chemistry. 277(40)
The yeast PHO2 gene encodes a homeodomain protein that exemplifies combinatorial control in transcriptional activation. Pho2 alone binds DNA in vitro with low affinity, but in vivo it activates transcription with at least three disparate DNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35478ed0eda0336b7c34df7e7bd7da6a
https://pubmed.ncbi.nlm.nih.gov/12145299
https://pubmed.ncbi.nlm.nih.gov/12145299
Regulation ofHOgene expression in the yeastSaccharomyces cerevisiaeis intricately orchestrated by an assortment of gene-specific DNA-binding and non-DNA binding regulators. Binding of the early G1transcription factor Swi5 to the distal URS1 element o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ede0030ae04011472ae85c368eb646
https://europepmc.org/articles/PMC312787/
https://europepmc.org/articles/PMC312787/
Autor:
David J. Stillman, Leena Bhoite
Publikováno v:
Molecular and cellular biology. 18(11)
The Swi5 zinc finger and the Pho2 homeodomain DNA-binding proteins bind cooperatively to the HO promoter. Pho2 (also known as Bas2 or Grf10) activates transcription of diverse genes, acting with multiple distinct DNA-binding proteins. We have perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c473200ffe6f5bfe983d297e1e8f254
https://pubmed.ncbi.nlm.nih.gov/9774660
https://pubmed.ncbi.nlm.nih.gov/9774660
Autor:
Christine E. Beattie, Le T. Hao, Leena Bhoite, Andrew D. Gassman, John Manfredi, Chad Bradford, Chi-Bin Chien
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e74325 (2013)
PLoS ONE, Vol 8, Iss 9, p e74325 (2013)
Proximal spinal muscular atrophy (SMA) is the most common inherited motor neuropathy and the leading hereditary cause of infant mortality. Currently there is no effective treatment for the disease, reflecting a need for pharmacologic interventions th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade8907953768142d9421b7a57b070ca
https://doi.org/10.1371/journal.pone.0074325
https://doi.org/10.1371/journal.pone.0074325
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
DNA replication in budding yeast cells depends on the activation of the Cdc28 kinase (Cdk1 of Saccharomyces cerevisiae) associated with B-type cyclins Clb1 to Clb6. Activation of the kinase depends on proteolysis of the Cdk inhibitor p40SIC1 in late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373d3d11d9149404ab6ef05de034ef67
https://europepmc.org/articles/PMC231570/
https://europepmc.org/articles/PMC231570/