Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Leena Alhonen"'
Autor:
Olga N. Ivanova, Anastasiya V. Snezhkina, George S. Krasnov, Vladimir T. Valuev-Elliston, Olga A. Khomich, Alexey R. Khomutov, Tuomo A. Keinanen, Leena Alhonen, Birke Bartosch, Anna V. Kudryavtseva, Sergey N. Kochetkov, Alexander V. Ivanov
Publikováno v:
Cells, Vol 7, Iss 12, p 275 (2018)
Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment. In particular, cancer cells exhibit elevated levels of bi
Externí odkaz:
https://doaj.org/article/ea67aed7265e479cb82b5746ed3972ce
Autor:
Mervi T. Hyvönen, Olga A. Smirnova, Vladimir A. Mitkevich, Vera L. Tunitskaya, Maxim Khomutov, Dmitry S. Karpov, Sergey P. Korolev, Merja R. Häkkinen, Marko Pietilä, Marina B. Gottikh, Jouko Vepsäläinen, Leena Alhonen, Alexander A. Makarov, Sergey N. Kochetkov, Heather M. Wallace, Tuomo A. Keinänen, Alex R. Khomutov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 9; Pages: 4614
The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key downregulator of the polyamine pool is the polyamine-inducible protein, antizyme 1 (OAZ1). OAZ1 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce39be386fe80d10da9fb9252770da08
https://pubmed.ncbi.nlm.nih.gov/35563006
https://pubmed.ncbi.nlm.nih.gov/35563006
Publikováno v:
Bio-Protocol, Vol 4, Iss 22 (2014)
The polyamines, spermidine (Spd) and spermine, and their diamine precursor putrescine, are important regulators of various cellular functions, such as proliferation and differentiation. Polyamine homeostasis is tightly regulated on the level of uptak
Externí odkaz:
https://doaj.org/article/30f52608431c4f81a9c7468c53912f2c
Autor:
Merja R. Häkkinen, Aino-Liisa Alanne, Sebahat Ucal, Mervi T. Hyvönen, Jouko Vepsäläinen, Tuomo A. Keinänen, Leena Alhonen
Publikováno v:
Biochemical Journal. 475:663-676
Replacing protium with deuterium is an efficient method to modulate drug metabolism. N-alkylated polyamine analogues are polyamine antimetabolites with proven anticancer efficacy. We have characterized earlier the preferred metabolic routes of N1,N12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54b6258be8e07bd20d128f1afc97387
https://doi.org/10.1042/bcj20170887
https://doi.org/10.1042/bcj20170887
Autor:
Pia Leppänen, Ivana Kholová, Anssi J Mähönen, Kari Airenne, Suvi Koota, Hannu Mansukoski, Johanna Närväinen, Maria Wirzenius, Leena Alhonen, Juhani Jänne, Kari Alitalo, Seppo Ylä-Herttuala
Publikováno v:
PLoS ONE, Vol 1, p e13 (2006)
We have generated a transgenic mouse where hVEGF-A(165) expression has been silenced with loxP-STOP fragment, and we used this model to study the effects of hVEGF-A(165) over-expression in mice after systemic adenovirus mediated Cre-gene transfer. Un
Externí odkaz:
https://doaj.org/article/b3e430171ec14f14a0e0055676d8a8ae
Autor:
Leena Alhonen, Mervi T. Hyvönen, A. R. Simonian, Tuomo A. Keinänen, Alex R. Khomutov, Sergey N. Kochetkov, Jouko Vepsäläinen, M. A. Khomutov, Janne Weisell
Publikováno v:
Mendeleev Communications. 28:479-481
The title compounds were prepared in high overall yields from properly protected (Boc, Cbz) 2- , 3- or 8-methyl-4-azaoctane-1,8-diamines. N1-Acetyl-2-methyl- and N1-acetyl-8-methylspermidines, but not N1-acetyl-3-methylspermidine, were the substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65978ac23ce5c9d419774435686bbdca
https://doi.org/10.1016/j.mencom.2018.09.008
https://doi.org/10.1016/j.mencom.2018.09.008
Autor:
Andrey A Formanovsky, A. R. Simonian, M. A. Khomutov, Leena Alhonen, Alex R. Khomutov, Alexander O. Chizhov, Sergey N. Kochetkov, Jouko Vepsäläinen, Tuomo A. Keinänen, I. V. Mikhura, Mervi T. Hyvönen
Publikováno v:
Journal of Medicinal Chemistry
The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in the regulation of vital cellular functions including proliferation and differentiation. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c6c352cfa90120fe5031a178726c3b
https://pubmed.ncbi.nlm.nih.gov/31765147
https://pubmed.ncbi.nlm.nih.gov/31765147
Autor:
Jouko Vepsäläinen, Anne Uimari, Qingqiu Huang, Nikolay Grigorenko, Leena Alhonen, Tuomo A. Keinänen, Alex R. Khomutov, Mervi T. Hyvönen
Publikováno v:
Bioscience Reports
Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO), human spermine (Spm) oxidase (SMOX) and yeast polyamine oxidase (Fms1), we demonstrate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122d17afef95b90b33dcfd2e9c2f0eb0
https://doi.org/10.1042/bsr20180527
https://doi.org/10.1042/bsr20180527
Autor:
M. A. Khomutov, Janne Weisell, Sergey N. Kochetkov, Tuomo A. Keinänen, Jouko Vepsäläinen, Alex R. Khomutov, Mervi T. Hyvönen, Leena Alhonen
Publikováno v:
Russian Journal of Bioorganic Chemistry. 41:548-553
Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity starting from commercially available R- and S-isomers of N-Boc-2-aminopropanol-1. Applicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab6897b1f9a85c3e74aa4af8f6a97a1
https://doi.org/10.1134/s1068162015050064
https://doi.org/10.1134/s1068162015050064
Autor:
Sergey N. Kochetkov, Marine J. Petit, Mervi T. Hyvönen, M. A. Khomutov, Jouko Vepsäläinen, Tuomo A. Keinänen, Leena Alhonen, Janne Weisell, Alex R. Khomutov
Publikováno v:
ACS Chemical Biology. 10:1417-1424
Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion of a specific Lys to hypusine [N(ε)-(4-amino-2-hydroxybutyl)lysine]. Deoxyhypusine synthas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a56796de0f5f5bf642e022c509a1aea
https://doi.org/10.1021/cb500938e
https://doi.org/10.1021/cb500938e