Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

Autor: Ulrike Kühbacher, Irene Gallina, Julio C Y Liu, Yoshiaki Azuma, Nicolai B. Larsen, Claire Guérillon, Nikoline Borgermann, Niels Mailand, Ronald T. Hay, Emma Branigan, Leena Ackermann, Dimitriya H Garvanska, Ivo A. Hendriks, Michael L. Nielsen, Peter Haahr, Julien P. Duxin

Publikováno v: Liu, J C Y, Kühbacher, U, Larsen, N B, Borgermann, N, Garvanska, D H, Hendriks, I A, Ackermann, L, Haahr, P, Gallina, I, Guérillon, C, Branigan, E, Hay, R T, Azuma, Y, Nielsen, M L, Duxin, J P & Mailand, N 2021, ' Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway ', E M B O Journal, vol. 40, e107413 . https://doi.org/10.15252/embj.2020107413
The EMBO Journal

DNA‐protein crosslinks (DPCs) obstruct essential DNA transactions, posing a serious threat to genome stability and functionality. DPCs are proteolytically processed in a ubiquitin‐ and DNA replication‐dependent manner by SPRTN and the proteasom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06fd624e33a326d63e7e57078ba37ff6
https://curis.ku.dk/ws/files/280729418/embj.2020107413.pdf

SUMOylation promotes protective responses to DNA-protein crosslinks

Autor: Hannes Lans, Petra Schwertman, Karen L. Thijssen, Nikoline Borgermann, Leena Ackermann, Niels Mailand, Julio C Y Liu, Ivo A. Hendriks, Michael L. Nielsen

Publikováno v: Borgermann, N, Ackermann, L, Schwertman, P, Hendriks, I A, Thijssen, K, Liu, J C, Lans, H, Nielsen, M L & Mailand, N 2019, ' SUMOylation promotes protective responses to DNA-protein crosslinks ', E M B O Journal, vol. 38, e101496 . https://doi.org/10.15252/embj.2019101496
The EMBO Journal
EMBO Journal, 38(8):e101496. Wiley-Blackwell

DNA‐protein crosslinks (DPCs) are highly cytotoxic lesions that obstruct essential DNA transactions and whose resolution is critical for cell and organismal fitness. However, the mechanisms by which cells respond to and overcome DPCs remain incompl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a2bbe01a2ad9d894ceeb591134ad99
https://curis.ku.dk/portal/da/publications/sumoylation-promotes-protective-responses-to-dnaprotein-crosslinks(b11db8db-def5-41da-b302-7aa5faa4f775).html

An epidemic of allergic contact dermatitis caused by a new allergen, caprylhydroxamic acid, in moisturizers

Autor: Leena, Ackermann, Hannele, Virtanen, Laura, Korhonen, Arja, Laukkanen, Laura, Huilaja, Riitta, Riekki, Taina, Hasan

Publikováno v: Contact dermatitis. 77(3)

In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6def03e6aff99ac8ac480de966f0f6b0
https://pubmed.ncbi.nlm.nih.gov/28421670

Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin

Autor: Thorsten Hoppe, André Franz, Leena Ackermann

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, Vol 7 (2016)

The dynamic composition of proteins associated with nuclear DNA is a fundamental property of chromosome biology. In the chromatin compartment dedicated protein complexes govern the accurate synthesis and repair of the genomic information and define t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f95c9c80a49b976e85487770bf39b85
http://europepmc.org/articles/PMC4853748

Multidisciplinary Management of Mastocytosis: Nordic Expert Group Consensus

Autor: Lene H. Garvey, Charlotte G. Mortz, Gunnar Nilsson, Peter Valent, Thomas Kielsgaard Kristensen, Ole Weis Bjerrum, Leena Ackermann, Trine Torfing, Theo Gülen, Maria Sääf, Eva Stylianou, Carsten Bindslev-Jensen, Ingunn Dybedal, Hanne Vestergaard, Birgitta Sander, Michael Boe Møller, Troels Havelund, Marie Bendix, Sigurd Broesby-Olsen, Anna Bergström, Maria A Karlsson, Lone Agertoft, Kim Brixen, Hans Hägglund, Pernille Hermann

Publikováno v: Broesby-Olsen, S, Dybedal, I, Gülen, T, Kristensen, T, Møller, M B, Ackermann, L, Sääf, M, Karlsson, M A, Agertoft, L, Brixen, K, Hermann, P, Stylianou, E, Mortz, C G, Torfing, T, Havelund, T, Sander, B, Bergström, A, Bendix, M, Garvey, L H, Bjerrum, O W, Valent, P, Bindslev-Jensen, C, Nilsson, G, Vestergaard, H & Hägglund, H 2016, ' Multidisciplinary Management of Mastocytosis : Nordic Expert Group Consensus ', Acta Dermatovenereologica, vol. 96, no. 5, pp. 602-612 . https://doi.org/10.2340/00015555-2325
Broesby-Olsen, S, Dybedal, I, Gülen, T, Kielsgaard Kristensen, T, Boe Møller, M, Ackermann, L, Sääf, M, Karlsson, M A, Agertoft, L, Brixen, K, Hermann, P, Stylianou, E, Mortz, C G, Torfing, T, Havelund, T, Sander, B, Bergström, A, Bendix, M, Garvey, L H, Weis Bjerrum, O, Valent, P, Bindslev-Jensen, C, Nilsson, G, Vestergaard, H & Hägglund, H 2016, ' Multidisciplinary Management of Mastocytosis : Nordic Expert Group Consensus ', Acta Dermato-Venereologica, vol. 96, no. 5, pp. 602-614 . https://doi.org/10.2340/00015555-2325

Mastocytosis is a heterogeneous group of diseases defined by an increased number and accumulation of mast cells, and often also by signs and symptoms of mast cell activation. Disease subtypes range from indolent to rare aggressive forms. Mastocytosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b43f3ca95fd776eb96c275fc9ce0e1
https://pubmed.ncbi.nlm.nih.gov/26694951