Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial

Autor: Jan Brzezicki, Ramon Toro-Torres, Juan Cruz Rizo Rodriguez, Eric C. Mueller, Atul Deodhar, Anna Dudek, Gunther Neeck, Roger J. Diegel, Maria Greenwald, Lianne S. Gensler, Hitoshi Goto, Judith Carrio, Seung Jae Hong, Cassandra M. Skinner, Yoshinori Taniguchi, Tatsuya Atsumi, Mikkel Østergaard, Shigeru Honjo, Clemens Scheinecker, Heinrich Resch, Rafal Plebanski, Yoshifuji Matsumoto, David H. Adams, Min Chan Park, Richard Roseff, David H. Goddard, Hiroaki Dobashi, Steven C. Kimmel, Johannes Grisar, Christine Thai, Sergio Duran Barragan, Chang Keun Lee, Tetsuya Tomita, Frederic Morin, Roel Querubin, Jose Maldonado Cocco, Craig D. Scoville, Philip J. Mease, Luminita Tronaru, Kurisu Tada, Denis Poddubnyy, Mohamed B. Sebai, Federico Ariel, Eleonora Lucero, Mark D. Harris, Kari K. Eklund, Melvin Churchill, Jeffrey L. Kaine, Cesar Ricardo Ramos Remus, Francisco Fidencio Cons Molina, Kazuhiro Hatta, Eun Bong Lee, Joachim Sieper, Alan Kivitz, Yukitaka Ueki, Jorge Velasco, Seong Wook Kang, Jürgen Braun, Sang-Heon Lee, Xiaoqi Li, Kentaro Inui, Leena Paimela, Michael E. Sayers, Arthur R. Mabaquiao, Antonio Scafuto Scotton, Sylke Wagner, Carlos Pantojas, Janina Drabiszcak-Piatkowska, Ana Maria Ramazan, Steven J. Klein, Proton Rahman, M. Hojnik, Marleen G H van de Sande, Tania L. Rivera, Amarilis Perez-De Jesus, Kathleen P. Flint, Jyothi R. Mallepalli, John E. Hull, Karel Pvelka, Evgeniya Schmidt, Mary P. Howell, Yuya Takakubo, Gaia Gallo, Walter P. Maksymowych, Joseph C. Shanahan, Marek Krogulec, Aaron Alejandro Barrera Rodriguez, Cesar Francisco Pacheco Tena, Anna Karjalainen, Pentti Jarvinen, Oscar Soto-Raices, Zdenek Dvorak, Désirée van der Heijde, Tokutaro Tsuda, Galina Matsievskaya, Sergey Yakushin, Eva Dokoupilova, Ann Leung, Luis Roimicher, Daniela Opris-Belinski, Pawel Hrycai, Tomasz Blicharshi, Kiyoshi Matsui, Hilde Carlier, Olga Ershova, Alberto Berman, Tae-Hwan Kim, Eric A. Peters, Marina Stanislav, Ana Claudia Melazzi, Martina Malcova, Louis Bessette, Sang-Hoon Lee, Helena Marzo-Ortega, Andrey Rebroy, Diego O. Viola, Rodolfo A Pardo Hidalgo

Publikováno v: Lancet, 395(10217), 53-64
Lancet, 395(10217), 53-64. Elsevier Limited

Summary Background Ixekizumab, a high-affinity interleukin-17A (IL-17A) monoclonal antibody, has previously shown efficacy in radiographic axial spondyloarthritis (also known as ankylosing spondylitis). We aimed to evaluate the efficacy and safety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de58e8a78134c8e494ab8c28ac8b159f
https://hdl.handle.net/1887/3181441

Infliximab for 6 months added on combination therapy in early rheumatoid arthritis: 2-year results from an investigator-initiated, randomised, double-blind, placebo-controlled study (the NEO-RACo Study)

Autor: Heikki Julkunen, Leena Laasonen, Pekka Hannonen, Kirsti Ilva, Hannu Kautiainen, Markku Korpela, Kari Puolakka, T Uutela, Riitta Luosujärvi, Markku J Kauppi, Eeva Moilanen, Harri Blåfield, Oili Kaipiainen-Seppänen, Leena Paimela, Anna Karjalainen, Timo Möttönen, Marjatta Leirisalo-Repo, Reijo Luukkainen

Publikováno v: Annals of the Rheumatic Diseases. 72:851-857

ObjectiveEarly treatment of patients with rheumatoid arthritis (RA) with combination treatment starting with methotrexate, sulfasalazine, hydroxychloroquine and prednisolone (FIN-RACo strategy) is superior to monotherapy. A study was undertaken to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2518dfd204f9d0ed9724339ec1a1427
https://doi.org/10.1136/annrheumdis-2012-201365

Causes of death in patients with rheumatoid arthritis autopsied during a 40-year period

Autor: Tapio Helve, Risto Suomalainen, Leena Paimela, Marjatta Leirisalo-Repo, Matti Karesoja, H Piirainen, Riitta Koivuniemi

Publikováno v: Rheumatology International. 28:1245-1252

We studied causes of death (CoDs) between 1952 and 1991 assessed by a clinician before autopsy and then determined at autopsy by a pathologist in 369 subjects with rheumatoid arthritis (RA) and 370 subjects without RA (non-RA). We analysed clinical d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394ef547e750f84f8a1f1ecfc015bcf7
https://doi.org/10.1007/s00296-008-0685-6

Infectious causes of death in patients with rheumatoid arthritis: an autopsy study

Autor: Riitta Koivuniemi, Marjatta Leirisalo-Repo, Leena Paimela, R Suomalainen, H Piirainen

Publikováno v: Scandinavian Journal of Rheumatology. 35:273-276

To study mortality from infections and accuracy of pre-mortem diagnoses in patients with rheumatoid arthritis (RA) autopsied during a 40-year period.We investigated infectious causes of death, findings at autopsy, and clinicians' estimation of cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd90f71a3d96e49c1a1a9493c27522ea
https://doi.org/10.1080/03009740600556258

Impact of initial aggressive drug treatment with a combination of disease-modifying antirheumatic drugs on the development of work disability in early rheumatoid arthritis: A five-year randomized followup trial

Autor: Reijo Luukkainen, Harri Blåfield, Markku Korpela, Timo Möttönen, Marjatta Leirisalo-Repo, Hannu Kautiainen, Kari Puolakka, Leena Paimela, Julkunen H, M Hakala, Pekka Hannonen, Kaisa Vuori

Publikováno v: Arthritis & Rheumatism. 50:55-62

Objective To compare the efficacy of therapy with a combination of disease-modifying antirheumatic drugs (DMARDs) versus therapy with a single DMARD in the prevention of work disability in patients with early rheumatoid arthritis (RA). Methods In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbed5b12b29e350812c9c98a4fc181d8
https://doi.org/10.1002/art.11436