Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Leena, Laitinen"'
Autor:
Hong Tsao, Yongkai Sun, Paresh P. Chothe, Amanda Moore, Leena Laitinen, Jennifer E. Sager, Niresh Hariparsad
Publikováno v:
Drug Metabolism and Disposition. 45:692-705
Typically, concentration-response curves are based upon nominal inducer concentrations for in-vitro-to-in-vivo extrapolation of CYP3A4 induction. The limitation of this practice is that it assumes the hepatocyte culture model is a static system. We a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0459581a368a4e777d9e59a6aa0d2ef0
https://doi.org/10.1124/dmd.117.075481
https://doi.org/10.1124/dmd.117.075481
Autor:
Niresh Hariparsad, Hong Tsao, Craig Zetterberg, Leena Laitinen, Francois Maltais, Shengkai Liao, Ananthsrinivas Chakilam
Publikováno v:
Drug Metabolism and Disposition. 44:1286-1295
(R)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanamide (VX-509, decernotinib) is an oral Janus kinase 3 inhibitor that has been studied in patients with rheumatoid arthritis. Patients with rheumatoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b027e83df4d0184cb1a0e1deca7ffc
https://doi.org/10.1124/dmd.116.071100
https://doi.org/10.1124/dmd.116.071100
Autor:
Veli-Matti Ulander, Leena Laitinen, Aila Tiitinen, Päivi J. Galambosi, Risto Kaaja, Vilho Hiilesmaa
Publikováno v:
Thrombosis research. 143
Introduction: In contrast to unfractionated heparin (UFH), use of low-molecular weight heparin (LMWH) during pregnancy has not been reported to be associated with a significant decrease in bone mineral density (BMD). The aim of this study was to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e8ca79bdbb1f675e5e1c06ba5229c5
https://pubmed.ncbi.nlm.nih.gov/27236710
https://pubmed.ncbi.nlm.nih.gov/27236710
Autor:
Eric Block, Hui Huang, Minzhang Chen, Christopher Town, Scott A. Raybuck, Young Chun Jung, Francois Maltais, Chien Ma, Christopher L Brummel, Robert B. Perni, Hongying Gao, Rebecca S. Shawgo, Jerry Tanoury, David Howe, Nagraj Mani, Leena Laitinen, Shengkai Liao, Youssef L. Bennani, Hong Tsao, S Pazhanisamy, Mark N. Namchuk
Publikováno v:
Journal of Medicinal Chemistry. 52:7993-8001
Telaprevir 2 (VX-950), an inhibitor of the hepatitis C virus (HCV(a)) NS3-4A protease, is in phase 3 clinical trials. One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3 (VRT-394), containing an inversion at the chiral center next to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1026c8ab8e4f24ba8a6ef16c25c45c80
https://doi.org/10.1021/jm901023f
https://doi.org/10.1021/jm901023f
Autor:
Hanna-Sisko Kortejärvi, Maija Koljonen, Arto Urtti, Sanna Siissalo, Ann Marie Kaukonen, Leena Laitinen, Kati-Sisko Vellonen, Jouni Hirvonen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 67:548-554
The mRNA level expression of MDR1, MRP1-6, BCRP and CYP3A4 was determined by quantitative PCR in wild type (Caco-2WT) and vinblastine-treated (Caco-2VBL) Caco-2 cells at different passage levels (32-53). Differentiation increased the mRNA levels of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0497554860ba263f4fa8a880c3da63d6
https://doi.org/10.1016/j.ejpb.2007.03.017
https://doi.org/10.1016/j.ejpb.2007.03.017
Autor:
Jaani Tuura, Teemu Heikkilä, Jouni Hirvonen, Jarno Salonen, Vesa-Pekka Lehto, Ann Marie Kaukonen, Leena Laitinen, Tarja Limnell
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 66:348-356
The combined release and permeation behavior of furosemide loaded into thermally carbonized mesoporous silicon (TCPSi) microparticles was studied in order to evaluate the potential of TCPSi-loading to improve permeation of furosemide, a BCS class IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c678166ec7e748825d76e73b4e9991
https://doi.org/10.1016/j.ejpb.2006.11.021
https://doi.org/10.1016/j.ejpb.2006.11.021
Autor:
David Messersmith, Harmon J. Zuccola, Thomas Hoock, Sudipta Mahajan, Christopher Town, M. Woods Wannamaker, Luke Oh, Jian Wang, James J. Black, Bin Fan, Pamela McCarthy, Francesco G. Salituro, Mark N. Namchuk, Christopher L Brummel, Valerie Marone, Warren Dorsch, Randy S. Bethiel, Mark W. Ledeboer, Edmund Harrington, Summer Halas, Dina Shlyakter, Lora Swenson, Cochran John E, Youssef L. Bennani, Arthur Rugg, David Howe, Albert C. Pierce, Shannon Dean, Marina Penney, Hui Huang, Tiansheng Wang, Gabriel Martinez-Botella, James K. Hogan, Ananthsrinivas Chakilam, Shengkai Liao, Michael J. Arnost, Kumkum Saxena, Luc J. Farmer, Scott A. Raybuck, Shi-Kai Tian, Dylan Jacobs, Leena Laitinen, Raymond J. Winquist
Publikováno v:
Journal of medicinal chemistry. 58(18)
While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a57998bf457ae6f3959a86c5e2312bb
https://pubmed.ncbi.nlm.nih.gov/26230873
https://pubmed.ncbi.nlm.nih.gov/26230873
Autor:
Kari Kreander, Marina Heinonen, Leena Laitinen, Päivi Tammela, Pia Vuorela, Satu Vuorela, Anna Galkin
Publikováno v:
Journal of Pharmacy and Pharmacology. 58:1545-1552
This study investigated the mutagenic, anti-mutagenic and cytotoxic effects of acetone extract of raspberry, Rubus idaeus L. (v. Ottawa) Rosaceae, and the isolated and characterized ellagitannin and anthocyanin fractions thereof, suitable for food ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c1b8bd1ed6fa4c39c2baff85c0b2da
https://doi.org/10.1211/jpp.58.11.0016
https://doi.org/10.1211/jpp.58.11.0016
Autor:
Tomi Järvinen, Hanna Kumpulainen, Hannu Raunio, Risto O. Juvonen, Marja Jaurakkajärvi, Jouko Vepsäläinen, Niina Mähönen, Jarkko Rautio, Marja-Leena Laitinen
Publikováno v:
Journal of Medicinal Chemistry. 49:1207-1211
Hydroxyimine derivatives of ketoprofen (1) and nabumetone (2) were synthesized and evaluated in vitro and in vivo as cytochrome P450-selective intermediate prodrug structures of ketones. 2 released nabumetone in vitro in the presence of isolated rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3016fbf4e5dfa9e056e77e071f2f4e4
https://doi.org/10.1021/jm0510124
https://doi.org/10.1021/jm0510124
Autor:
Kalle Vähä-Heikkilä, Jarno Salonen, Mikko Björkqvist, Vesa-Pekka Lehto, Ann Marie Kaukonen, Jaani Tuura, Teemu Heikkilä, Leena Laitinen, Jouni Hirvonen
Publikováno v:
Journal of Controlled Release. 108:362-374
Mesoporous silicon (PSi) microparticles were produced using thermal carbonization (TCPSi) or thermal oxidation (TOPSi) to obtain surfaces suitable for oral drug administration applications. The loading of five model drugs (antipyrine, ibuprofen, gris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dab0f52d11a34c2206528cff1ba3c3c
https://doi.org/10.1016/j.jconrel.2005.08.017
https://doi.org/10.1016/j.jconrel.2005.08.017