Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid

Autor: Lotte Cornelli, Ruben Van Paemel, Maísa R. Ferro dos Santos, Sofie Roelandt, Leen Willems, Jelle Vandersteene, Edward Baert, Liselot M. Mus, Nadine Van Roy, Bram De Wilde, Katleen De Preter

Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)

Abstract Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detail to discriminate between different tumor types, while the histopathological examination of tumor tissue shows high int

Externí odkaz: https://doaj.org/article/b09b088a6a4a4632a066f2855b72dcb8

The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer

Autor: Mirjam E. van deVelde, Marleen. H. van denBerg, Gertjan J. L. Kaspers, Floor C. H. Abbink, Jos W. R. Twisk, Inge M. van derSluis, Cor van denBos, Marry M. van denHeuvel‐Eibrink, Heidi Segers, Christophe Chantrain, Jutte van derWerff Ten Bosch, Leen Willems, Raphaële R. L. vanLitsenburg

Publikováno v: Cancer Medicine, Vol 10, Iss 22, Pp 8172-8181 (2021)

Abstract Purpose Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR‐induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health‐related quality

Externí odkaz: https://doaj.org/article/e5e35beb568340dda7f7b38abc4d5585

Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4

Autor: Sofie Nelissen, Tim Vangansewinkel, Nathalie Geurts, Lies Geboes, Evi Lemmens, Pia M. Vidal, Stefanie Lemmens, Leen Willems, Francesco Boato, Dearbhaile Dooley, Debora Pehl, Gunnar Pejler, Marcus Maurer, Martin Metz, Sven Hendrix

Publikováno v: Neurobiology of Disease, Vol 62, Iss , Pp 260-272 (2014)

Mast cells (MCs) are found abundantly in the central nervous system and play a complex role in neuroinflammatory diseases such as multiple sclerosis and stroke. In the present study, we show that MC-deficient KitW-sh/W-sh mice display significantly i

Externí odkaz: https://doaj.org/article/c4ea801aa65d481681b4c71e2b849fbb

Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients

Autor: Mirjam E. van de Velde, Aniek Uittenboogaard, Wenjian Yang, Erik Bonten, Cheng Cheng, Deqing Pei, Marleen H. van den Berg, Inge M. van der Sluis, Cor van den Bos, Floor C. H. Abbink, Marry M. van den Heuvel-Eibrink, Heidi Segers, Christophe Chantrain, Jutte van der Werff ten Bosch, Leen Willems, William E. Evans, Gertjan J. L. Kaspers

Publikováno v: Cancers; Volume 14; Issue 14; Pages: 3510
Cancers, 14(14):3510. Multidisciplinary Digital Publishing Institute (MDPI)
van de Velde, M E, Uittenboogaard, A, Yang, W, Bonten, E, Cheng, C, Pei, D, van den Berg, M H, van der Sluis, I M, van den Bos, C, Abbink, F C H, van den Heuvel-Eibrink, M M, Segers, H, Chantrain, C, van der Werff ten Bosch, J, Willems, L, Evans, W E & Kaspers, G J L 2022, ' Genetic Polymorphisms Associated with Vincristine Pharmacokinetics and Vincristine-Induced Peripheral Neuropathy in Pediatric Oncology Patients ', Cancers, vol. 14, no. 14, 3510 . https://doi.org/10.3390/cancers14143510

Vincristine (VCR) is an important component of curative chemotherapy for many childhood cancers. Its main side effect is VCR-induced peripheral neuropathy (VIPN), a dose limiting toxicity. Some children are more susceptible to VIPN, which is at least

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf2606b06ed8365ca7f44d2297b555b
https://pubmed.ncbi.nlm.nih.gov/35884569

Hearing Loss in Malignant Infantile Osteopetrosis: A Case-Based Review

Autor: Elise, De Cuyper, Céline, De Cuyper, Leen, Willems, Jan, Casselman, Ingeborg, Dhooge, Helen, Van Hoecke

Publikováno v: Journal of International Advanced Otology, Vol 17, Iss 6, Pp 551-558 (2021)
JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY

Osteopetrosis, or marble bone disease, is a rare genetic disease of bone resorption. It includes a clinically heterogeneous group of conditions that are characterized by increased bone density on radiographs due to a defect in osteoclasts. A most com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc185cbd35a1d515deb6d5fbfad2f391
https://pubmed.ncbi.nlm.nih.gov/35177394