Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Leen M. ‘t Hart"'
Autor:
Shiying Li, Iulian Dragan, Van Du T. Tran, Chun Ho Fung, Dmitry Kuznetsov, Michael K. Hansen, Joline W. J. Beulens, Leen M. ‘t Hart, Roderick C. Slieker, Louise A. Donnelly, Mathias J. Gerl, Christian Klose, Florence Mehl, Kai Simons, Petra J. M. Elders, Ewan R. Pearson, Guy A. Rutter, Mark Ibberson
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionType 2 diabetes (T2D) onset, progression and outcomes differ substantially between individuals. Multi-omics analyses may allow a deeper understanding of these differences and ultimately facilitate personalised treatments. Here, in an unsu
Externí odkaz:
https://doaj.org/article/8020ce5607d8402da7325136b175bf1e
Autor:
Annemieke Naber, Daniel Demus, Roderick C. Slieker, Simone Nicolardi, Joline W. J. Beulens, Petra J. M. Elders, Aloysius G. Lieverse, Eric J. G. Sijbrands, Leen M. ‘t Hart, Manfred Wuhrer, Mandy van Hoek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5365 (2024)
Apolipoprotein-CIII (apo-CIII) inhibits the clearance of triglycerides from circulation and is associated with an increased risk of diabetes complications. It exists in four main proteoforms: O-glycosylated variants containing either zero, one, or tw
Externí odkaz:
https://doaj.org/article/0e134a42768641449a1bfdfded36d2c7
Autor:
Gerard A. Bouland, Joline W. J. Beulens, Joey Nap, Arno R. van der Slik, Arnaud Zaldumbide, Leen M. ’t Hart, Roderick C. Slieker
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Aims/hypothesis Numerous genome-wide association studies have been performed to understand the influence of genetic variation on type 2 diabetes etiology. Many identified risk variants are located in non-coding and intergenic regions, which
Externí odkaz:
https://doaj.org/article/3ad7c553e70d4b9ba2a38b7010f19527
Autor:
Annemieke Naber, Daniel Demus, Roderick Slieker, Simone Nicolardi, Joline W. J. Beulens, Petra J. M. Elders, Aloysius G. Lieverse, Eric J. G. Sijbrands, Leen M. ’t Hart, Manfred Wuhrer, Mandy van Hoek
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14844 (2023)
Apolipoprotein-CIII (apo-CIII) is involved in triglyceride-rich lipoprotein metabolism and linked to beta-cell damage, insulin resistance, and cardiovascular disease. Apo-CIII exists in four main proteoforms: non-glycosylated (apo-CIII0a), and glycos
Externí odkaz:
https://doaj.org/article/229cfd966d7a4751a0e6cd2820ab143d
Autor:
Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Background Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes duration, number of visits and length of follow-up. Here, we characterize glyce
Externí odkaz:
https://doaj.org/article/db9e99db550c41419fd5f84c64666dd3
Autor:
Morgan O. Obura, Irene GM van Valkengoed, Femke Rutters, Leen M. ’t Hart, Simone P. Rauh, Eric Moll van Charante, Marieke B. Snijder, Joline WJ Beulens
Publikováno v:
Global Heart, Vol 16, Iss 1 (2021)
Background: Most risk assessment models for type 2 diabetes (T2DM) have been developed in Caucasians and Asians; little is known about their performance in other ethnic groups. Objective(s): We aimed to identify existing models for the risk of preval
Externí odkaz:
https://doaj.org/article/021704269dbf4aa19523a4b604f7dc13
Autor:
Soheil Yousefi, Tooba Abbassi-Daloii, Thirsa Kraaijenbrink, Martijn Vermaat, Hailiang Mei, Peter van ‘t Hof, Maarten van Iterson, Daria V. Zhernakova, Annique Claringbould, Lude Franke, Leen M. ‘t Hart, Roderick C. Slieker, Amber van der Heijden, Peter de Knijff, BIOS consortium, Peter A. C. ’t Hoen
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background SNP panels that uniquely identify an individual are useful for genetic and forensic research. Previously recommended SNP panels are based on DNA profiles and mostly contain intragenic SNPs. With the increasing interest in RNA expr
Externí odkaz:
https://doaj.org/article/0e8138dd70e8467994de1cfcfd00291b
Autor:
Jana V. van Vliet-Ostaptchouk, Timon W. van Haeften, Gijs W. D. Landman, Erwin Reiling, Nanne Kleefstra, Henk J. G. Bilo, Olaf H. Klungel, Anthonius de Boer, Cleo C. van Diemen, Cisca Wijmenga, H. Marike Boezen, Jacqueline M. Dekker, Esther van 't Riet, Giel Nijpels, Laura M. C. Welschen, Hata Zavrelova, Elinda J. Bruin, Clara C. Elbers, Florianne Bauer, N. Charlotte Onland-Moret, Yvonne T. van der Schouw, Diederick E. Grobbee, Annemieke M. W. Spijkerman, Daphne L. van der A, Annemarie M. Simonis-Bik, Elisabeth M. W. Eekhoff, Michaela Diamant, Mark H. H. Kramer, Dorret I. Boomsma, Eco J. de Geus, Gonneke Willemsen, P. Eline Slagboom, Marten H. Hofker, Leen M. 't Hart
Publikováno v:
PLoS ONE, Vol 7, Iss 6 (2012)
Externí odkaz:
https://doaj.org/article/76154e90636b40dabf402b0cc3f9e7b6
Autor:
Xinyu Li, Anoukh van Giessen, James Altunkaya, Roderick C. Slieker, Joline W.J. Beulens, Leen M. ‘t Hart, Ewan R. Pearson, Petra J.M. Elders, Talitha L. Feenstra, Jose Leal
Publikováno v:
Li, X, van Giessen, A, Altunkaya, J, Slieker, R C, Beulens, J W J, ‘t Hart, L M, Pearson, E R, Elders, P J M, Feenstra, T L & Leal, J 2023, ' Potential Value of Identifying Type 2 Diabetes Subgroups for Guiding Intensive Treatment : A Comparison of Novel Data-Driven Clustering With Risk-Driven Subgroups ', Diabetes Care, vol. 46, no. 7, pp. 1395-1403 . https://doi.org/10.2337/dc22-2170
Diabetes Care. AMER DIABETES ASSOC
Diabetes Care. AMER DIABETES ASSOC
OBJECTIVE To estimate the impact on lifetime health and economic outcomes of different methods of stratifying individuals with type 2 diabetes, followed by guideline-based treatment intensification targeting BMI and LDL in addition to HbA1c. RESEARCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace8b5455460305d7a9f28fa1457c468
https://doi.org/10.2337/dc22-2170
https://doi.org/10.2337/dc22-2170
Autor:
Juliette A. de Klerk, Joline W. J. Beulens, Hailiang Mei, Roel Bijkerk, Anton Jan van Zonneveld, Robert W. Koivula, Petra J. M. Elders, Leen M. ’t Hart, Roderick C. Slieker
Publikováno v:
Diabetologia, 66(6), 1057-1070. Springer Verlag
de Klerk, J A, Beulens, J W J, Mei, H, Bijkerk, R, van Zonneveld, A J, Koivula, R W, Elders, P J M, ’t Hart, L M & Slieker, R C 2023, ' Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism : a Mendelian randomisation study ', Diabetologia, vol. 66, no. 6, pp. 1057-1070 . https://doi.org/10.1007/s00125-023-05886-8
de Klerk, J A, Beulens, J W J, Mei, H, Bijkerk, R, van Zonneveld, A J, Koivula, R W, Elders, P J M, ’t Hart, L M & Slieker, R C 2023, ' Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism : a Mendelian randomisation study ', Diabetologia, vol. 66, no. 6, pp. 1057-1070 . https://doi.org/10.1007/s00125-023-05886-8
Aims/hypothesis The aim of this study was to identify differentially expressed long non-coding RNAs (lncRNAs) and mRNAs in whole blood of people with type 2 diabetes across five different clusters: severe insulin-deficient diabetes (SIDD), severe ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea52a35e62700b83debe83291a455903
https://research.vumc.nl/en/publications/c0f95e31-b148-4e23-aa6f-502a037a592e
https://research.vumc.nl/en/publications/c0f95e31-b148-4e23-aa6f-502a037a592e