Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Leen J M, Seys"'
Autor:
Laurens Zwanenburg, Jimmy Borloo, Bregt Decorte, Myrna J. M. Bunte, Sanaz Mokhtari, Sonia Serna, Niels-C. Reichardt, Leen J. M. Seys, Angela van Diepen, Arjen Schots, Ruud H. P. Wilbers, Cornelis H. Hokke, Edwin Claerebout, Peter Geldhof
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract The development of effective recombinant vaccines against parasitic nematodes has been challenging and so far mostly unsuccessful. This has also been the case for Ostertagia ostertagi, an economically important abomasal nematode in cattle, a
Externí odkaz:
https://doaj.org/article/a608e2c84ed44f5fa0e498328daafac3
Autor:
Benoit Misset, Hans Slabbynck, Ursula Smole, Linos Vandekerckhove, Nicolas Dauby, Helena Catharine Aegerter, Nicolas De Schryver, Jozefien Declercq, Catherine Legrand, Levi Hoste, Gil Verschelden, Fre Bauters, Xavier Wittebole, Bastiaan Maes, Eva Van Braeckel, Sébastien Anguille, Catherine Van Der Straeten, Marc Buyse, Sylvie Rottey, Tom Fivez, Dieter Stevens, Stefaan J. Vandecasteele, Maya Hites, Elke Govaerts, I Peene, Karel Van Damme, Simon Tavernier, Frank Hulstaert, Roos Colman, Stefanie De Buyser, Elisabeth De Leeuw, Jeroen Van der Hilst, Filip Moerman, Fabienne Liénart, Leen J M Seys, Leslie Naesens, Filomeen Haerynck, Ingel K. Demedts, Cedric Bosteels, Victor Bosteels, Pieter Depuydt, Johan Van Laethem, Bart N. Lambrecht
Publikováno v:
The Lancet. Respiratory Medicine
The Lancet. Respiratory medicine, Vol. 9, no.12, p. 1427-1438 (2021)
The lancet respiratory medicine
The Lancet. Respiratory medicine, Vol. 9, no.12, p. 1427-1438 (2021)
The lancet respiratory medicine
Background Infections with SARS-CoV-2 continue to cause significant morbidity and mortality. Interleukin (IL)-1 and IL-6 blockade have been proposed as therapeutic strategies in COVID-19, but study outcomes have been conflicting. We sought to study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c947dee87ae75466e399e2163313e8a
https://doi.org/10.1016/s2213-2600(21)00377-5
https://doi.org/10.1016/s2213-2600(21)00377-5
Autor:
Leen J M Seys, Fien M Verhamme, Lisa L Dupont, Elke Desauter, Julia Duerr, Ayca Seyhan Agircan, Griet Conickx, Guy F Joos, Guy G Brusselle, Marcus A Mall, Ken R Bracke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129897 (2015)
Airway surface dehydration, caused by an imbalance between secretion and absorption of ions and fluid across the epithelium and/or increased epithelial mucin secretion, impairs mucociliary clearance. Recent evidence suggests that this mechanism may b
Externí odkaz:
https://doaj.org/article/f500d0f6563d431289fad7355f5ca904
Autor:
Ellen De Meester, Alexander Botzki, Leen J M Seys, Peter Vandenabeele, Filip Van Nieuwerburgh, Tuur Muyldermans, Jonathan Maelfait, Bart N. Lambrecht, Evelien Dierick, Bartosz Wiernicki, Katrien Staes, Richard de Reuver
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109500-(2021)
Cell Reports, 36(6):109500. Cell Press
CELL REPORTS
Cell Reports, 36(6):109500. Cell Press
CELL REPORTS
Summary: Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1 (ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS). ADAR1 converts adenosines into inosines within dsRNA. This process called A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67227824facd3f1ec08aff363d515a37
https://doi.org/10.1016/j.celrep.2021.109500
https://doi.org/10.1016/j.celrep.2021.109500
Autor:
Guy Brusselle, Wim Janssens, Bart L. Haagmans, Guy Joos, Leen J M Seys, Ken R. Bracke, Alex KleinJan, Fien Verhamme, W. Widagdo
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Clinical Infectious Diseases, 66(1), 45-53. Oxford University Press
Clinical Infectious Diseases, 66(1), 45-53. Oxford University Press
The MERS coronavirus receptor, dipeptidyl peptidase 4 is upregulated in the lungs of smokers and chronic obstructive pulmonary disease (COPD) patients. This offers a potential mechanism for the increased susceptibility of smokers and COPD patients fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad338e08435e91313095d7dab41eafb
http://europepmc.org/articles/PMC7108100
http://europepmc.org/articles/PMC7108100
Autor:
Fien M. Verhamme, Pieter Mestdagh, Griet Conickx, Guy Joos, Jo Vandesompele, Francisco Avila Cobos, Alan Hsu, Leen J M Seys, Philip M. Hansbro, Ken R. Bracke, Guy Brusselle, Peter A. B. Wark, Richard Kim, Tania Maes, Lies Lahousse, Bart M. Vanaudenaerde
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 195:43-56
Aberrant expression of microRNAs (miRNAs) can have a detrimental role in disease pathogenesis.To identify dysregulated miRNAs in lung tissue of patients with chronic obstructive pulmonary disease (COPD).We performed miRNA and mRNA profiling using hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531cf2768992b6e38ba7efa9f9886b1c
https://doi.org/10.1164/rccm.201506-1182oc
https://doi.org/10.1164/rccm.201506-1182oc
Autor:
Yannick Morias, Johan Mattsson, Thomas Naessens, Eva Hamrud, Karl J. Staples, Kristofer Thörn, Ulf Gehrmann, Guy Brusselle, Faye Melville, Danen Cunoosamy, Elisabeth Israelsson, Bart N. Lambrecht, Leen J M Seys, Gabriel Skogberg, Ken R. Bracke
Publikováno v:
Airway cell biology and immunopathology.
Introduction: Emerging evidence supports a crucial role for tertiary lymphoid organs (TLO) in chronic obstructive pulmonary disease (COPD) progression. However, mechanisms underlying TLO generation during COPD remain to be defined. Aim: We hypothesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::819d7e6ffb8a8491533dfb8ebe16c92e
https://doi.org/10.1183/13993003.congress-2019.pa1676
https://doi.org/10.1183/13993003.congress-2019.pa1676
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L687-L695
Chronic inflammatory responses in the lungs contribute to the development and progression of chronic obstructive pulmonary disease (COPD). Although research studies focused initially on the contributions of the innate immune system to the pathogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5cee61bf8606a91b26e6359add7467
https://doi.org/10.1152/ajplung.00304.2016
https://doi.org/10.1152/ajplung.00304.2016
Autor:
Bart M. Vanaudenaerde, Colin D. Bingle, Leen J M Seys, Elise G De Smet, Ken R. Bracke, Guy Brusselle, Fien M. Verhamme
Publikováno v:
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
International Journal of Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
Elise G De Smet,1 Leen JM Seys,1,2 Fien M Verhamme,1 Bart M Vanaudenaerde,3 Guy G Brusselle,1 Colin D Bingle,4 Ken R Bracke1 1Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent Universit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6dd0611a8bbc2307db5f0a0b446237
https://lirias.kuleuven.be/handle/123456789/615216
https://lirias.kuleuven.be/handle/123456789/615216
Publikováno v:
Epidemiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0e9c4cc021edec33a2759814fc93396
https://doi.org/10.1183/1393003.congress-2017.pa1564
https://doi.org/10.1183/1393003.congress-2017.pa1564