Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leen Farhat-Younis"'
Autor:
Leen Farhat-Younis, Manho Na, Amichai Zarfin, Aseel Khateeb, Nadine Santana-Magal, Alon Richter, Amit Gutwillig, Diana Rasoulouniriana, Annette Gleiberman, Lir Beck, Tamar Giger, Avraham Ashkenazi, Adi Barzel, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/f9a3adc13def42b0b29b48a9f758942d
Autor:
Leen Farhat-Younis, Manho Na, Amichai Zarfin, Aseel Khateeb, Nadine Santana-Magal, Alon Richter, Amit Gutwillig, Diana Rasoulouniriana, Annette Gleiberman, Lir Beck, Tamar Giger, Avraham Ashkenazi, Adi Barzel, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 12 (2024)
Despite the central role of T cells in tumor immunity, attempts to harness their cytotoxic capacity as a therapy have met limited efficacy, partially as a result of the suppressive microenvironment which limits their migration and activation. In cont
Externí odkaz:
https://doaj.org/article/8b32bc93547d4d01a1ed2717a985adc2
Autor:
Amit Gutwillig, Nadine Santana-Magal, Leen Farhat-Younis, Diana Rasoulouniriana, Asaf Madi, Chen Luxenburg, Jonathan Cohen, Krishnanand Padmanabhan, Noam Shomron, Guy Shapira, Annette Gleiberman, Roma Parikh, Carmit Levy, Meora Feinmesser, Dov Hershkovitz, Valentina Zemser-Werner, Oran Zlotnik, Sanne Kroon, Wolf-Dietrich Hardt, Reno Debets, Nathan Edward Reticker-Flynn, Peleg Rider, Yaron Carmi
Publikováno v:
eLife, Vol 11 (2022)
Despite the remarkable successes of cancer immunotherapies, the majority of patients will experience only partial response followed by relapse of resistant tumors. While treatment resistance has frequently been attributed to clonal selection and immu
Externí odkaz:
https://doaj.org/article/fb33e4cafa1a4209ba1b058808d753b4
Autor:
Diana Rasoulouniriana, Nadine Santana-Magal, Amit Gutwillig, Leen Farhat-Younis, Lior Tal, Sarah Amar, Michael Milyavsky, Siva Sai Naga Anurag Muddineni, Neta Solomon, Hana Shpilt, Shahar Dotan, Noam Pilpel, Claudia Waskow, Meora Feinmesser, Peleg Rider, Yaron Carmi
Publikováno v:
Cancer Immunology Research. :OF1-OF18
The pioneering design of chimeric antigen receptor (CAR) T-cell therapy demonstrated the potential of reprogramming the immune system. Nonetheless, T-cell exhaustion, toxicity, and suppressive microenvironments limit their efficacy in solid tumors. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2450bd40e191e33c039896c5ef96a739
https://doi.org/10.1158/2326-6066.cir-22-0423
https://doi.org/10.1158/2326-6066.cir-22-0423
Autor:
Yaron Carmi, Peleg Rider, Meora Feinmesser, Claudia Waskow, Noam Pilpel, Shahar Dotan, Hana Shpilt, Neta Solomon, Siva Sai Naga Anurag Muddineni, Michael Milyavsky, Sarah Amar, Lior Tal, Leen Farhat-Younis, Amit Gutwillig, Nadine Santana-Magal, Diana Rasoulouniriana
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a828b462c9d6002c2d495c8387f825dc
https://doi.org/10.1158/2326-6066.22651051
https://doi.org/10.1158/2326-6066.22651051
Autor:
Yaron Carmi, Peleg Rider, Nathan E. Reticker-Flynn, Ian L. Linde, Haim Gutman, Oran Zlotnik, Meora Feinmesser, Rachel Blau, Ron Shamir, Dvir Netanely, Lior Tal, Diana Rasoulouniriana, Annette Gleiberman, Amit Gutwillig, Leen Farhat-Younis, Nadine Santana-Magal
Melanoma tumor cells secrete lysosomes which are taken up by dendritic cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aa16b2f62d7eeeedff4ea1bfa17b7f
https://doi.org/10.1158/0008-5472.22423346.v1
https://doi.org/10.1158/0008-5472.22423346.v1
Autor:
Yaron Carmi, Peleg Rider, Nathan E. Reticker-Flynn, Ian L. Linde, Haim Gutman, Oran Zlotnik, Meora Feinmesser, Rachel Blau, Ron Shamir, Dvir Netanely, Lior Tal, Diana Rasoulouniriana, Annette Gleiberman, Amit Gutwillig, Leen Farhat-Younis, Nadine Santana-Magal
Cell numbers of multiple immune cell substes, and mainly dendritic cells, are decreased over time in melanoma tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8ab8dc9ec2cacb40bc60874cdce5d6
https://doi.org/10.1158/0008-5472.22423352.v1
https://doi.org/10.1158/0008-5472.22423352.v1
Autor:
Yaron Carmi, Peleg Rider, Nathan E. Reticker-Flynn, Ian L. Linde, Haim Gutman, Oran Zlotnik, Meora Feinmesser, Rachel Blau, Ron Shamir, Dvir Netanely, Lior Tal, Diana Rasoulouniriana, Annette Gleiberman, Amit Gutwillig, Leen Farhat-Younis, Nadine Santana-Magal
Tumor antigens are drained into sentinel lymph nodes independently of dendritic cell migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c34f7561e2776d320b0356e8b288dd
https://doi.org/10.1158/0008-5472.22423349
https://doi.org/10.1158/0008-5472.22423349
Autor:
Yaron Carmi, Peleg Rider, Nathan E. Reticker-Flynn, Ian L. Linde, Haim Gutman, Oran Zlotnik, Meora Feinmesser, Rachel Blau, Ron Shamir, Dvir Netanely, Lior Tal, Diana Rasoulouniriana, Annette Gleiberman, Amit Gutwillig, Leen Farhat-Younis, Nadine Santana-Magal
Higher doses of immunmotherapy do not induce tumor regression when administrated to large melanoma lesions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d043a2c894f843c9ca0dddca0ddfcc68
https://doi.org/10.1158/0008-5472.22423358.v1
https://doi.org/10.1158/0008-5472.22423358.v1
Autor:
Diana Rasoulouniriana, Nadine Santana-Magal, Amit Gutwillig, Leen Farhat-Younis, Hana Shpilt, Shahar Dotan, Noam Pilpel, Peleg Rider, Yaron Carmi
Publikováno v:
Cancer Research. 83:4075-4075
The pioneering design of chimeric antigen receptor T-cell (CAR-T) therapy demonstrated the potential of reprogramming the immune system. Nonetheless, T-cell exhaustion, toxicity, and suppressive microenvironment limit their efficacy in solid tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cc12ea778c4e91e9db1eee1a8e32c0
https://doi.org/10.1158/1538-7445.am2023-4075
https://doi.org/10.1158/1538-7445.am2023-4075