Výsledky vyhledávání - "Leen De Rycke"

Synovial Tissue Response to Treatment with TNF Blockers in Peripheral Spondyloarthritis

Autor: Jacqueline E Paramarta, Leen De Rycke, Dominique Baeten

Publikováno v: open rheumatology journal, 5, 127-132. Bentham Science Publishers B.V.
The Open Rheumatology Journal

This review describes the synovial response to treatment in peripheral spondyloarthritis (SpA). A series of recent studies demonstrates that the synovial histopathology is largely homogenous between different SpA subtypes and can be strongly modulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb2ed8150e17a68b90a2524c9de83f6
https://doi.org/10.2174/1874312901105010127

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Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis

Autor: Rik Joos, Eric Veys, Bernard Vandooren, Paul P. Tak, Annemieke M. H. Boots, Juan D. Cañete, Veronique Van den Bossche, Elli Kruithof, Dominique Baeten, Leen De Rycke

Publikováno v: Arthritis and rheumatism, 54(8), 2594-2604. John Wiley and Sons Inc.

Objective To characterize the synovial immunopathologic features of juvenile-onset spondylarthritis (SpA) in relation to adult SpA and other forms of juvenile idiopathic arthritis (JIA). Methods Synovial biopsy samples were obtained from 10 patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f986951be5daa32cb776e540d4be8020
https://doi.org/10.1002/art.22024

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Identification of synovial biomarkers of response to experimental treatment in early-phase clinical trials in spondylarthritis

Autor: Dominique Baeten, Eric Veys, Elli Kruithof, Oliver FitzGerald, Paul P. Tak, Iain B. McInnes, Barry Bresnihan, Leen De Rycke, Bernard Vandooren, Filip De Keyser

Publikováno v: Arthritis and rheumatism, 54(6), 1795-1804. John Wiley and Sons Inc.

Objective To identify biomarkers for effective treatment in early-phase clinical trials of spondylarthritis (SpA), by analyzing which synovial features can be reliably identified in patients with SpA. Methods Synovial biopsies were performed at weeks

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d0211f7abad14abcacbdfe7ca05024
https://doi.org/10.1002/art.21914

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Infliximab, but not etanercept, induces IgM anti-double-stranded DNA autoantibodies as main antinuclear reactivity: biologic and clinical implications in autoimmune arthritis

Autor: Leen De Rycke, Filip Van den Bosch, Dominique Baeten, Elli Kruithof, Filip De Keyser, Eric Veys

Publikováno v: Arthritis and rheumatism, 52(7), 2192-2201. John Wiley and Sons Inc.

Objective To analyze the clinical and biologic correlates of autoantibody induction during longer-term tumor necrosis factor α (TNFα) blockade with either the monoclonal antibody infliximab or the soluble receptor etanercept. Methods Thirty-four pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4984e0e45dcf7f6c1cbd71f444572e8
https://doi.org/10.1002/art.21190

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Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity

Autor: Tineke Cantaert, Elli Kruithof, Leen De Rycke, Filip De Keyser, Anthony P. Nicholas, Bart Vandekerckhove, Dominique Baeten, Eric Veys, Joshua D. Echols

Publikováno v: Arthritis and rheumatism, 52(8), 2323-2330. John Wiley and Sons Inc.

Objective To address the ongoing debate concerning the specificity of synovial citrullinated proteins for rheumatoid arthritis (RA) and to analyze their pathophysiologic relevance to the induction or perpetuation of the RA-specific anti–citrullinat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f82918d149d026333724c9d452254e7
https://doi.org/10.1002/art.21220

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Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor ? blockade in spondylarthropathy

Autor: Bernard Vandooren, Filip Van den Bosch, Filip De Keyser, Dominique Baeten, Eric Veys, Elli Kruithof, Markus Rihl, Jieruo Gu, David T. Y. Yu, Leen De Rycke

Publikováno v: Arthritis and rheumatism, 50(9), 2942-2953. John Wiley and Sons Inc.

Objective To investigate the role of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in spondylarthropathy (SpA) synovitis. Methods Paired samples of synovial biopsy tissue as well as serum and synovial flu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1902f5e876943c9d3f32b5c3721ba9
https://doi.org/10.1002/art.20477

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Antinuclear antibodies following infliximab treatment in patients with rheumatoid arthritis or spondylarthropathy

Autor: Leen De Rycke, Eric Veys, Filip Van den Bosch, Elli Kruithof, Nancy Van Damme, Ilse Hoffman, Filip De Keyser, Nancy Van den Bossche

Publikováno v: Arthritis & Rheumatism. 48:1015-1023

Objective To investigate the effect of infliximab treatment on antinuclear antibodies (ANAs), anti–double-stranded DNA (anti-dsDNA), antinucleosome, antihistone, and anti–extractable nuclear antigen (anti-ENA) antibodies in rheumatoid arthritis (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec83009c23bd54d30d13d9587bf875f
https://doi.org/10.1002/art.10876

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Calprotectin (S100A8/9) as serum biomarker for clinical response in proof-of-concept trials in axial and peripheral spondyloarthritis

Autor: Dominique Baeten, Jacqueline E Paramarta, Leen De Rycke, Nataliya Yeremenko, M. Turina

Publikováno v: Arthritis research & therapy, 16(4). BioMed Central
Arthritis Research & Therapy

Introduction Biomarkers complementing clinical evaluations may help to reduce the length and size of proof-of-concept (PoC) trials aimed to obtain quick “go/no go” decisions in the clinical development of new treatments. We aimed to identify and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150c6d7c171474203fbfe0b23d4e0ba9
https://doi.org/10.1186/s13075-014-0413-4

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Undifferentiated spondyloarthritis vs ankylosing spondylitis and psoriatic arthritis: a real-life prospective cohort study of clinical presentation and response to treatment

Autor: Dominique Baeten, Paul P. Tak, Jacqueline E Paramarta, Carmen A. Ambarus, Leen De Rycke

Publikováno v: Rheumatology (Oxford, England), 52(10), 1873-1878. Oxford University Press

Objective. SpA is a phenotypically heterogeneous disease, with AS and PsA as its best studied subtypes. This study aimed to investigate whether, despite a different phenotypic presentation, patients with undifferentiated SpA (uSpA) have similar disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2ba59d92bc9e081f1012705e26c5c
https://pubmed.ncbi.nlm.nih.gov/24080862

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Efficacy and safety of adalimumab for the treatment of peripheral arthritis in spondyloarthritis patients without ankylosing spondylitis or psoriatic arthritis

Autor: Koen Vos, Huib J. Dinant, Tanja F Heijda, Leen De Rycke, Paul P. Tak, Jacqueline E Paramarta, Carmen A. Ambarus, Dominique Baeten

Publikováno v: Annals of the rheumatic diseases, 72(11), 1793-1799. BMJ Publishing Group

Objectives To evaluate the efficacy and safety of adalimumab in patients with peripheral spondyloarthritis (SpA) not fulfilling the criteria for ankylosing spondylitis (AS) or psoriatic arthritis (PsA). Methods 40 patients with active peripheral SpA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23068d15f786d581226464caf03090e2
https://pubmed.ncbi.nlm.nih.gov/23139265

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