AID in non-Hodgkin B-cell lymphomas: The consequences of on- and off-target activity.

Autor: Leeman-Neill RJ; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States. Electronic address: rjl2165@cumc.columbia.edu., Bhagat G; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States., Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.

Publikováno v: Advances in immunology [Adv Immunol] 2024; Vol. 161, pp. 127-164. Date of Electronic Publication: 2024 Mar 31.

Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression.

Autor: Leeman-Neill RJ; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Song D; SIAT-HKUST Joint Laboratory of Cell Evolution and Digital Health, Shenzhen-Hong Kong Collaborative Innovation Research Institute, Shenzhen, China.; Division of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Bizarro J; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Wacheul L; RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S./FNRS), Université libre de Bruxelles (ULB), Biopark Campus, Gosselies, Belgium., Rothschild G; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Singh S; Institut für Medizinische Physik und Biophysik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Yang Y; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China., Sarode AY; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Gollapalli K; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Wu L; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Zhang W; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Chen Y; Division of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China., Lauring MC; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Whisenant DE; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Bhavsar S; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Lim J; Department of Pharmacy, School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju, Republic of Korea., Swerdlow SH; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Bhagat G; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Zhao Q; State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China., Berchowitz LE; Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA., Lafontaine DLJ; RNA Molecular Biology, Fonds de la Recherche Scientifique (F.R.S./FNRS), Université libre de Bruxelles (ULB), Biopark Campus, Gosselies, Belgium., Wang J; SIAT-HKUST Joint Laboratory of Cell Evolution and Digital Health, Shenzhen-Hong Kong Collaborative Innovation Research Institute, Shenzhen, China. jgwang@ust.hk.; Division of Life Science, Department of Chemical and Biological Engineering, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China. jgwang@ust.hk.; Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong SAR, China. jgwang@ust.hk., Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York City, NY, USA. ub2121@cumc.columbia.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Dec; Vol. 55 (12), pp. 2160-2174. Date of Electronic Publication: 2023 Dec 04.

The clinical and pathological features of plasma cell myeloma post solid organ transplantation.

Autor: Ofori K; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Soderquist CR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Murty VV; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Park D; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Vlad G; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Leeman-Neill RJ; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Lentzsch S; Division of Hematology/Oncology, Columbia University Irving Medical Center, New York City, New York, US., Alobeid B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US., Bhagat G; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, New York, US.

Publikováno v: American journal of hematology [Am J Hematol] 2020 Dec; Vol. 95 (12), pp. 1531-1541. Date of Electronic Publication: 2020 Sep 17.

The Common Key to Class-Switch Recombination and Somatic Hypermutation: Discovery of AID and Its Role in Antibody Gene Diversification.

Autor: Leeman-Neill RJ; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and.; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032., Lim J; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and., Basu U; Department of Microbiology and Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032; and ub2121@cumc.columbia.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Nov 01; Vol. 201 (9), pp. 2527-2529.

BCL6 as a therapeutic target for lymphoma.

Autor: Leeman-Neill RJ; a Department of Pathology and Cell Biology , Columbia University Medical Center , New York , USA., Bhagat G; a Department of Pathology and Cell Biology , Columbia University Medical Center , New York , USA.

Publikováno v: Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2018 Feb; Vol. 22 (2), pp. 143-152. Date of Electronic Publication: 2018 Jan 04.