Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Leela Goodspeed"'
Autor:
Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 3, Pp 100174- (2022)
Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and co
Externí odkaz:
https://doaj.org/article/8ffc4aeca8934757a42ccde986d1a313
Autor:
Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107818- (2020)
Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obe
Externí odkaz:
https://doaj.org/article/0ab5266a0eec4194a0bd5b3e2ad576af
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227830 (2020)
Estrogens are important for maintaining metabolic health in males. However, the key sources of local estrogen production for regulating energy metabolism have not been fully defined. Immune cells exhibit aromatase activity and are resident in metabol
Externí odkaz:
https://doaj.org/article/53f402a55b064808a1112826da71d4a5
Autor:
Laura J. den Hartigh, Leela Goodspeed, Shari A. Wang, Heidi L. Kenerson, Mohamed Omer, Kevin D. O'Brien, Warren Ladiges, Raymond Yeung, Savitha Subramanian
Publikováno v:
Experimental Physiology, Vol 103, Iss 11, Pp 1469-1480 (2018)
New Findings What is the central question of this study? Whether chronic oral rapamycin promotes beneficial effects on glucose/lipid metabolism and energy balance when administered to mice with an obesogenic diet rich in saturated fat and sucrose has
Externí odkaz:
https://doaj.org/article/0d1ac30dac254f139ce9ae2ee60b9052
Autor:
Katya B Rubinow, Barbara Houston, Shari Wang, Leela Goodspeed, Kayoko Ogimoto, Gregory J Morton, Christopher McCarty, Robert E Braun, Stephanie T Page
Publikováno v:
Asian Journal of Andrology, Vol 20, Iss 3, Pp 276-283 (2018)
Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor (AR) is expressed in monocytes/macrophages, which are resident in key metabolic tis
Externí odkaz:
https://doaj.org/article/9a1337f7c38f4243a0f5b086461988fb
Autor:
Laura J den Hartigh, Shari Wang, Leela Goodspeed, Tomasz Wietecha, Barbara Houston, Mohamed Omer, Kayoko Ogimoto, Savitha Subramanian, G A Nagana Gowda, Kevin D O'Brien, Karl J Kaiyala, Gregory J Morton, Alan Chait
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172912 (2017)
BACKGROUND:Widely used as a weight loss supplement, trans-10,cis-12 conjugated linoleic acid (10,12 CLA) promotes fat loss in obese mice and humans, but has also been associated with insulin resistance. OBJECTIVE:We therefore sought to directly compa
Externí odkaz:
https://doaj.org/article/b68becef00ec4893a2579e0537d569ae
Autor:
Savitha Subramanian, Michael S. Turner, Yilei Ding, Leela Goodspeed, Shari Wang, Jane H. Buckner, Kevin O'Brien, Godfrey S. Getz, Catherine A. Reardon, Alan Chait
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2831-2841 (2013)
Obesity is a chronic inflammatory state characterized by infiltration of adipose tissue by immune cell populations, including T lymphocytes. Natural killer T (NKT) cells, a specialized lymphocyte subset recognizing lipid antigens, can be pro- or anti
Externí odkaz:
https://doaj.org/article/23a12788d7474eb28246d48885291959
Autor:
Tomio Umemoto, Savitha Subramanian, Yilei Ding, Leela Goodspeed, Shari Wang, Chang Yeop Han, Antonio Sta. Teresa, Jinkyu Kim, Kevin D. O'Brien, Alan Chait
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2380-2389 (2012)
Adipose tissue inflammation is associated with insulin resistance and increased cardiovascular disease risk in obesity. We previously showed that addition of cholesterol to a diet rich in saturated fat and refined carbohydrate significantly worsens d
Externí odkaz:
https://doaj.org/article/1c063bfd10f24d9f9aab549983572aed
Autor:
Savitha Subramanian, Leela Goodspeed, Shari Wang, Jinkyu Kim, Lixia Zeng, George N. Ioannou, W. Geoffrey Haigh, Matthew M. Yeh, Kris V. Kowdley, Kevin D. O'Brien, Subramaniam Pennathur, Alan Chait
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 9, Pp 1626-1635 (2011)
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver disease. Mechanisms that underlie this progression remain poorly understood, partly due to lack
Externí odkaz:
https://doaj.org/article/b93dae1dab6f45a5bc4196f64f7feadc
Autor:
Laura J den Hartigh, Shari Wang, Leela Goodspeed, Yilei Ding, Michelle Averill, Savitha Subramanian, Tomasz Wietecha, Kevin D O'Brien, Alan Chait
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108564 (2014)
Serum amyloid A (SAA) increases in response to acute inflammatory stimuli and is modestly and chronically elevated in obesity. SAA3, an inducible form of SAA, is highly expressed in adipose tissue in obese mice where it promotes monocyte chemotaxis,
Externí odkaz:
https://doaj.org/article/444ce7faf282459eae97ed450a40aba6