Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Leela Daya–Grosjean"'
Publikováno v:
Cancer Letters. 250:213-219
The predisposition to skin cancers in childhood is the hallmark of xeroderma pigmentosum (XP), a rare autosomal recessive disorder, deficient in DNA repair and hypersensitive to ultraviolet irradiation. Human papillomavirus (HPVs), are common infecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7ddbce8b6d328a49c4ee377f02a958
https://doi.org/10.1016/j.canlet.2006.10.008
https://doi.org/10.1016/j.canlet.2006.10.008
Autor:
Leela Daya-Grosjean, Alain Spatz, Christian Hiesse, Jean Pierre Armand, Sophie Queille, Alain Sarasin, Lionel Luron, Marie-Françoise Avril, Vincent Ribrag, Pierre Duvillard
Publikováno v:
Carcinogenesis. 28:724-731
Immunosuppressed renal transplant recipients (RTRs) are predisposed to non-melanoma skin cancers (NMSCs), predominantly squamous cell carcinomas (SCCs). We have analyzed skin lesions from RTRs with aggressive tumors for p53 gene modifications, the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf894351ad2a03316996e90a5eff957
https://doi.org/10.1093/carcin/bgl191
https://doi.org/10.1093/carcin/bgl191
Publikováno v:
Cancer Letters. 225:181-192
The development of basal cell carcinoma, the commonest human cancer in fair skinned populations, is clearly associated with constitutive activation of sonic hedgehog signaling. Insight into the genesis of BCC came from the identification of germline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1544eaf4a7da02640ee04ed23e0a87
https://doi.org/10.1016/j.canlet.2004.10.003
https://doi.org/10.1016/j.canlet.2004.10.003
Autor:
Alain Sarasin, Leela Daya-Grosjean
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 571:43-56
Xeroderma pigmentosum (XP), a rare hereditary syndrome, is characterized by a hypersensitivity to solar irradiation due to a defect in nucleotide excision repair resulting in a predisposition to squamous and basal cell carcinomas as well as malignant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37175db285225464218a41f3e8eceb71
https://doi.org/10.1016/j.mrfmmm.2004.11.013
https://doi.org/10.1016/j.mrfmmm.2004.11.013
Autor:
K. Mollier, Nicole Basset-Seguin, F.R. de Gruijl, Alain Sarasin, Leela Daya-Grosjean, Anny Fourtanier, Nadem Soufir, Emeric Roux, Sophie Queille
Publikováno v:
Molecular Carcinogenesis. 39:195-198
To characterize further the role of the INK4a-ARF locus in the multistep process of skin carcinogenesis, we performed a mutational analysis of this locus in skin lesions from hairless mice either irradiated with UVB alone or with a solar simulator de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929be92b477e7fa88af0cbf67f31488c
https://doi.org/10.1002/mc.20004
https://doi.org/10.1002/mc.20004
Autor:
M. Ribojad, Thierry Magnaldo, J. Rivet, Gisele Delestaing, Nicole Basset-Seguin, O. Thibaudeau, Nadem Soufir, Alain Sarasin, Leela Daya-Grosjean
Publikováno v:
Journal of Investigative Dermatology. 119(6):1355-1360
Xeroderma pigmentosum is an inheritable autosomal recessive DNA repair deficient syndrome characterized by a high predisposition to skin cancers. An elevated proportion of tumors from xeroderma pigmentosum patients harbor ultraviolet-induced mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035c98316749cc46bde74131b65a435f
Autor:
Alain Sarasin, Monique Vuillaume, Andras Perl, Ghislaine Martin, Fabienne Lachaise, Maurice Wegnez, Leela Daya-Grosjean, Christianne Drougard
Publikováno v:
Free Radical Biology and Medicine. 30:1365-1373
Xeroderma Pigmentosum (XP) is a rare recessively inherited human disease associated with a hypersensitivity to ultraviolet radiation. The ultraviolet component of sunlight can initiate and promote the formation of cutaneous tumors as seen in the skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542da0cb292dd89e27db4f9ae88f7670
https://doi.org/10.1016/s0891-5849(01)00532-9
https://doi.org/10.1016/s0891-5849(01)00532-9
Autor:
Alain Sarasin, Leela Daya-Grosjean
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 450:193-199
Germline mutations of the human patched gene, PTCH, are responsible for the nevoid basal cell carcinoma (NBCC) syndrome or Gorlin's syndrome, characterized by multiple skin cancers, internal cancers and severe developmental abnormalities. The patched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb38a286e6a22ef19a1ca95a42afe0f
https://doi.org/10.1016/s0027-5107(00)00025-7
https://doi.org/10.1016/s0027-5107(00)00025-7
Autor:
Bakar Bouadjar, Christiane Drougard, Alain Sarasin, Marie-Françoise Avril, Nathalie Bodak, Leela Daya-Grosjean, Sophie Queille
Publikováno v:
Proceedings of the National Academy of Sciences. 96:5117-5122
Recently, hptc , a human gene homologous to the Drosophila segment polarity gene patched ( ptc ), has been implicated in the nevoid basal-cell carcinoma (BCC) syndrome, and somatic mutations of hptc also have been found in sporadic BCCs, the most fre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032b3ffcee142f8a4418aa9edf31b670
https://doi.org/10.1073/pnas.96.9.5117
https://doi.org/10.1073/pnas.96.9.5117
Autor:
Christiane Drougard, Sophie Seite, Chantal Medaisko, Alain Sarasin, Sophie Queille, Sylvie Tison, Leela Daya-Grosjean, Anny Fourtanier
Publikováno v:
Molecular Carcinogenesis. 22:167-174
We investigated skin lesions induced in hairless SKH:HR1 mice by chronic exposure to a solar ultraviolet light (UV) simulator for alterations of the p53 gene in conserved domains. Mutations of exons 5-8 of the p53 gene in skin lesions were screened i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e50d6126c4b283073b5e9c57267267a
https://doi.org/10.1002/(sici)1098-2744(199807)22:3<167::aid-mc4>3.0.co
https://doi.org/10.1002/(sici)1098-2744(199807)22:3<167::aid-mc4>3.0.co