Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Leela Cherian"'
Autor:
Lamin Mbye, Robert Garcia, James M. Tour, J. Clay Goodman, Leela Cherian, Thomas A. Kent, Claudia S. Robertson, Paul J. Derry, Kimberly Mendoza, Lizanne G. Nilewski
Publikováno v:
J Neurotrauma
Hypotension worsens outcome after all severities of traumatic brain injury (TBI), with loss of cerebral autoregulation being a potential contributor. Previously, we demonstrated that intravenous injection of a high capacity catalytic antioxidant, pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9db55564f03185f72ce01c123e0d2a5
https://europepmc.org/articles/PMC6602099/
https://europepmc.org/articles/PMC6602099/
Autor:
Yuqing Chen, Ming-Ming Jiang, Shan Chen, George Al Shamy, Leela Cherian, Zixue Jin, Clay Goodman, Brendan Lee, Elda Munivez, Philippe M. Campeau, Claudia S. Robertson, Simran Madan, Qin Sun, Bettina Kron, Rajiv R. Ratan
Publikováno v:
Molecular genetics and metabolism. 125(1-2)
Arginine is a semi-essential amino acid which serves as a substrate for nitric oxide (NO) production by nitric oxide synthase (NOS) and a precursor for various metabolites including ornithine, creatine, polyamines, and agmatine. Arginase competes wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d430890c7c558932d816468b0aaf9508
https://pubmed.ncbi.nlm.nih.gov/30055993
https://pubmed.ncbi.nlm.nih.gov/30055993
Autor:
Matthew N. Rasband, Claudia S. Robertson, Leela Cherian, Miguel A. Marin, Kelli Baalman, Tammy Szu-Yu Ho, Marlesa Godoy
Publikováno v:
The Journal of Neuroscience. 35:2283-2292
Microglia are the brain's resident immune cells and function as the main defense against pathogens or injury. However, in the absence of disease, microglia have other functions in the normal brain. For example, previous studies showed that microglia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c9496cd04e95802165ac897ccd09915
https://doi.org/10.1523/jneurosci.3751-14.2015
https://doi.org/10.1523/jneurosci.3751-14.2015
Autor:
Claudia S. Robertson, Raymond J. Grill, Tian Siva Tian, Leela Cherian, H. Julia Hannay, Mahek Shah, Carla Cerami Hand, Jovany Cruz Navarro, Robert Garcia
Publikováno v:
Journal of Neurotrauma. 29:1156-1166
Pyroglutamate helix B surface peptide (pHBSP) is an 11 amino acid peptide, designed to interact with a novel cell surface receptor, composed of the classical erythropoietin (EPO) receptor disulfide linked to the beta common receptor. pHBSP has the cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd75b5b863e1c7032ee4e299e7a3521b
https://doi.org/10.1089/neu.2011.1827
https://doi.org/10.1089/neu.2011.1827
Autor:
Leela Cherian, Raymond J. Grill, Claudia S. Robertson, Shibu Pillai, Jovany Cruz Navarro, Robert Garcia
Publikováno v:
Journal of Neurotrauma. 29:322-334
The purpose of this study was to investigate the increased susceptibility of the brain, after a controlled mild cortical impact injury, to a secondary ischemic insult. The effects of the duration and the timing of the secondary insult after the initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91ac22ea2f9b668b603f018710e12f5
https://doi.org/10.1089/neu.2011.1979
https://doi.org/10.1089/neu.2011.1979
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:451-456
Darbepoetin alfa (darbEpo) is an erythropoietic glycoprotein that activates the erythropoietin receptor. The aim of our study was to determine whether darbEpo is neuroprotective in a cortical impact injury (CII) model and to determine the characteris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c02d0e8a46f04183d51f60a0ce5072
https://doi.org/10.1124/jpet.110.176602
https://doi.org/10.1124/jpet.110.176602
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:789-794
This study was designed to determine the effect of erythropoietin (Epo) on cerebral blood flow (CBF), nitric oxide (NO) concentration, and neurological outcome after traumatic brain injury. In one experiment, the hemodynamic effects of Epo were deter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44b548cf4082a48f7d42fb34e019f01
https://doi.org/10.1124/jpet.107.119628
https://doi.org/10.1124/jpet.107.119628
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 56:1235-1240
Background: Oxidative DNA lesions have not been well studied in traumatic brain injury (TBI). Methods: TBI was induced with a controlled cortical impact injury in rats. Brain tissue was examined for 8-hydroxy2'-deoxyguanosine (oh8dG) using monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61fa0f206cc5e377d631c27d5140024
https://doi.org/10.1097/01.ta.0000130759.62286.0e
https://doi.org/10.1097/01.ta.0000130759.62286.0e
Publikováno v:
Brain Pathol
Nitric oxide (NO) is a gaseous chemical messenger which has functions in the brain in a variety of broad physiological processes, including control of cerebral blood flow, interneuronal communications, synaptic plasticity, memory formation, receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbeb99ddaf4845190ea16c1ff8a3c87
https://doi.org/10.1111/j.1750-3639.2004.tb00053.x
https://doi.org/10.1111/j.1750-3639.2004.tb00053.x
Publikováno v:
Journal of Neurotrauma. 15:1059-1066
Previous studies had shown that pre- and postinjury glucose administration increased brain injury caused by a mild cortical impact injury only when the traumatic injury was complicated by a secondary ischemic insult. The purpose of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9310b7abf64e7362810fcc59c8efbdca
https://doi.org/10.1089/neu.1998.15.1059
https://doi.org/10.1089/neu.1998.15.1059