The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug

Autor: Anthony J. Day, Douglas P. Dyer, Nikolaos Kouvatsos, Leela C Biant, Jennifer M. Thomson, Caroline M. Milner, Andrew Price, Sanjay Anand, Eckart Bartnik, Jenny L Scott, Matthias Herrmann, Sheona P Drummond, Thomas Leeuw

Publikováno v: Osteoarthritis and Cartilage.

ObjectivesTo investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA.MethodsKnee articular cartilages from OA pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d3fc25757917baa910be09d877c244
https://doi.org/10.1016/j.joca.2023.05.013

Custom Implants in TKA Provide No Substantial Benefit in Terms of Outcome Scores, Reoperation Risk, or Mean Alignment: A Systematic Review

Autor: Eran Beit Ner, Leela C Biant, Saad Dosani, Gwenllian Tawy

Publikováno v: Clin Orthop Relat Res
Ner, E B, Dosani, S, Biant, L & Tawy, G 2021, ' Custom Implants in TKA Provide No Substantial Benefit in Terms of Outcome Scores, Reoperation Risk, or Mean Alignment: A Systematic Review ', Clinical Orthopaedics and Related Research . https://doi.org/10.1097/CORR.0000000000001651

Background Failure to accurately replicate the native anatomy and biomechanics of the knee has been suggested to contribute to dissatisfaction after TKA. Custom implants promise a personalized surgical approach, with the aim of improving patient sati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de85fc86dc26d5a8ab8ee14717540280
https://doi.org/10.1097/corr.0000000000001651

Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review

Autor: Anthony J. Freemont, James G. Convill, Leela C Biant, Gwenllian Tawy

Publikováno v: Convill, J G, Tawy, G, Freemont, T & Biant, L 2020, ' Clinically Relevant Molecular Biomarkers for use in Human Knee Osteoarthritis: A Systematic Review ', Cartilage, pp. 1947603520941239 . https://doi.org/10.1177/1947603520941239

Objective Biomarkers in osteoarthritis (OA) could serve as objective clinical indicators for various disease parameters, and act as surrogate endpoints in clinical trials for disease-modifying drugs. The aim of this systematic review was to produce a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a63fcfcba3f2f7902bcc752726d957
https://doi.org/10.1177/1947603520941239

Cost of Disability

Autor: Gwenllian Tawy, Leela C Biant

Publikováno v: Joint Function Preservation ISBN: 9783030829575
Tawy, G & Biant, L 2021, Cost of Disability . in A Gobbi, J G Lane, U G Longo & I Dallo (eds), Joint Function Preservation . Springer Nature, Cham, Switzerland, pp. 33-41 . https://doi.org/10.1007/978-3-030-82958-2_3

Damage to the osteo-chondral (OC) unit can result in a personal, economic, and societal burden of disability.The cost to patients are wider than the symptoms of pain and functional limitation. Lost working days can cause financial insecurity; particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9e0d7f4df868eef495a1a43c847dc7
https://doi.org/10.1007/978-3-030-82958-2_3

The Relationships between Coronal Plane Alignments and Patient-Reported Outcomes Following High Tibial Osteotomy: A Systematic Review

Autor: Leela C Biant, Hamza Shahbaz, Gwenllian Tawy, Michael J. McNicholas

Publikováno v: Cartilage. 13(1_suppl)

Objective This systematic review aimed to determine whether coronal angular corrections correlate with patient reported outcomes following valgus-producing high tibial osteotomy (HTO). Design Ovid MEDLINE, Embase, and Web of Science were systematical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fff97c860ee1f7e8099309bb21b372
https://pubmed.ncbi.nlm.nih.gov/33884908