Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leela, Shrestha"'
Autor:
Huanyu Z. Li, Ashley C. W. Pike, Irina Lotsaris, Gamma Chi, Jesper S. Hansen, Sarah C. Lee, Karin E. J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Robert J. Vandenberg, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. T
Externí odkaz:
https://doaj.org/article/32dcb0d22d77485888ff653efcd48c4e
Autor:
Simon R. Bushell, Ashley C. W. Pike, Maria E. Falzone, Nils J. G. Rorsman, Chau M. Ta, Robin A. Corey, Thomas D. Newport, John C. Christianson, Lara F. Scofano, Chitra A. Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M. M. Mukhopadhyay, James D. Love, Nicola A. Burgess-Brown, Rebecca Sitsapesan, Phillip J. Stansfeld, Juha T. Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P. Carpenter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to
Externí odkaz:
https://doaj.org/article/602dd2cc133c49529d8807b7b0d875ca
Autor:
Thomas J. McCorvie, Paula M. Loria, Meihua Tu, Seungil Han, Leela Shrestha, D. Sean Froese, Igor M. Ferreira, Allison P. Berg, Wyatt W. Yue
Publikováno v:
Nature Structural & Molecular Biology. 29:628-638
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We pre
Autor:
Huanyu Z. Li, Ashley C.W. Pike, Gamma Chi, Jesper S. Hansen, Sarah G. Lee, Karin E.J. Rödström, Simon R. Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A. Burgess-Brown, Timothy R. Dafforn, Elisabeth P. Carpenter, David B. Sauer
Proline is widely known as the only proteogenic amino acid with a secondary amine. In addition to its crucial role in protein structure, the secondary amino acid modulates neurotransmission and regulates the kinetics of signaling proteins. To underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd0b3c1551d3725c4f410b48f6a6e46
https://doi.org/10.1101/2023.05.17.541173
https://doi.org/10.1101/2023.05.17.541173
Autor:
Laiyin Nie, S.R. Bushell, Victoria Cole, Paul Brennan, Tiago Moreira, A. Quigley, Gian Filippo Ruda, Leela Shrestha, James D. Love, Tomas C. Pascoa, N.A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Elisabeth P. Carpenter, A. Chu, Ashley C. W. Pike, David Speedman
Publikováno v:
Nat Struct Mol Biol
Very long chain fatty acids (VLCFAs) are essential building blocks for the synthesis of ceramides and sphingolipids. The first step in the fatty acid elongation cycle is catalyzed by the 3-keto acyl-coenzyme A (CoA) synthases (in mammals, ELOVL elong
Autor:
Thomas J, McCorvie, Paula M, Loria, Meihua, Tu, Seungil, Han, Leela, Shrestha, D Sean, Froese, Igor M, Ferreira, Allison P, Berg, Wyatt W, Yue
Publikováno v:
Nature structuralmolecular biology. 29(7)
Glycogen synthase (GYS1) is the central enzyme in muscle glycogen biosynthesis. GYS1 activity is inhibited by phosphorylation of its amino (N) and carboxyl (C) termini, which is relieved by allosteric activation of glucose-6-phosphate (Glc6P). We pre
Autor:
Paul Brennan, James D. Love, Leela Shrestha, Laiyin Nie, Gian Filippo Ruda, Tomas C. Pascoa, Shubhashish M.M. Mukhopadhyay, A. Chu, A. Quigley, Victoria Cole, Tiago Moreira, S.R. Bushell, Elisabeth P. Carpenter, N.A. Burgess-Brown, Ashley C. W. Pike, David Speedman
Very long chain fatty acids (VLCFAs) are essential building blocks for synthesis of the ceramides and sphingolipids required for nerve, skin and retina function and 3-keto acyl-CoA synthases (ELOVL elongases) perform the first step in the FA elongati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7454b44666c6c5228050e372073713a1
https://doi.org/10.1101/2020.11.11.378570
https://doi.org/10.1101/2020.11.11.378570
Autor:
Leela Shrestha, Heinrich Meier, Stephen J. Tucker, Shubhashish M.M. Mukhopadhyay, Aytug K. Kiper, Elisabeth P. Carpenter, N.A. Burgess-Brown, Susanne Rinné, Ashley C. W. Pike, Michael G. Hahn, Karin E. J. Rödström, Wei Zhang, A. Quigley, Thomas Müller, Matthias Goldstein, Magdalena Platzk, David Speedman, Niels Decher, Martina Delbeck, Linus J. Conrad
TWIK-related acid-sensitive potassium (TASK) channels—members of the two pore domain potassium (K2P) channel family—are found in neurons1, cardiomyocytes2–4 and vascular smooth muscle cells5, where they are involved in the regulation of heart r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096eaf3bc556c30ff74ca034592deea8
https://ora.ox.ac.uk/objects/uuid:ccfd06d8-38f8-4a7f-826c-b775098feab8
https://ora.ox.ac.uk/objects/uuid:ccfd06d8-38f8-4a7f-826c-b775098feab8
Autor:
Marie-Laëtitia Thézénas, N.A. Burgess-Brown, Roman Fischer, Patrick J Venables, Leela Shrestha, Anna B Montgomery, Wyatt W. Yue, Jolanta Kopec
Publikováno v:
Annals of the Rheumatic Diseases
BackgroundPeriodontitis (PD) is a known risk factor for rheumatoid arthritis (RA) and there is increasing evidence that the link between the two diseases is due to citrullination by the unique bacterial peptidylarginine deiminase (PAD) enzyme express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91009714b4b08847a71601c014b2f8fc
https://ora.ox.ac.uk/objects/uuid:6944c2a9-e1c6-4a1f-82b8-ea85eb3b80ee
https://ora.ox.ac.uk/objects/uuid:6944c2a9-e1c6-4a1f-82b8-ea85eb3b80ee
Autor:
Magdalena Platzk, Matthias Goldstein, Karin E. J. Rödström, Thomas Mueller, N.A. Burgess-Brown, Niels Decher, David Speedman, A. Quigley, Leela Shrestha, Ashley C. W. Pike, Stephen J. Tucker, Aytug K. Kiper, Michael G. Hahn, Wei Zhang, Martina Delbeck, Susanne Rinné, Heinrich Meier, Linus J. Conrad, Elisabeth P. Carpenter, Shubhashish M.M. Mukhopadhyay
TASK channels are unusual members of the two-pore domain potassium (K2P) channel family, with unique and unexplained physiological and pharmacological characteristics. TASKs are found in neurons1,2, cardiomyocytes3–5 and vascular smooth muscle cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17291ea4dc5113dfd63aa4378c450609
https://doi.org/10.1101/706168
https://doi.org/10.1101/706168