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Background Improvement of patient with cancer outcome can be achieved by identifying novel mechanisms that underlie cancer pathogenesis. GTP cyclohydrolase (GTPCH) is the rate-limiting enzyme for neopterin and tetrahydrobiopterin (BH4) synthesis. Ele

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https://ora.ox.ac.uk/objects/uuid:a38cf8c4-a732-499d-84c2-c712f8f10163

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Role of Delta-like 4 in Jagged1-induced tumour angiogenesis and tumour growth

Autor: Oon, C, Bridges, E, Sheldon, H, Sainson, R, Jubb, A, Turley, H, Leek, R, Buffa, F, Harris, A, Li, J

Publikováno v: Oncotarget. 8(25)

Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key Notch ligands implicated in tumour angiogenesis. They were shown to have opposite effects on mouse retinal and adult regenerative angiogenesis. In tumours, both ligands are upregulated but their rela

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Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma (OPSCC):Hypoxia biomarkers from 64Cu-ATSM PET/CT imaging

Autor: Suh, Yae-Eun, Lawler, Katherine Joanne, Henley-Smith, Rhonda, Pike, Lucy, Leek, R, Barrington, Sally Fiona, Odell, Edward William, Ng, Tony Tsz-cheong, Pezzella, Francesco, Guerrero-Urbano, Maria Teresa, Tavassoli, Mahvash

Publikováno v: Suh, Y-E, Lawler, K J, Henley-Smith, R, Pike, L, Leek, R, Barrington, S F, Odell, E W, Ng, T T, Pezzella, F, Guerrero-Urbano, M T & Tavassoli, M 2017, ' Association between hypoxic volume and underlying hypoxia-induced gene expression in oropharyngeal squamous cell carcinoma (OPSCC) : Hypoxia biomarkers from 64Cu-ATSM PET/CT imaging ', British Journal of Cancer, vol. 116, pp. 1057–1064 . https://doi.org/10.1038/bjc.2017.66

Background: Hypoxia imaging is a promising tool for targeted therapy but the links between imaging features and underlying molecular characteristics of the tumour have not been investigated. The aim of this study was to compare hypoxia biomarkers and

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https://kclpure.kcl.ac.uk/en/publications/1f111c37-d6f9-4adb-90c9-d856af6c7212

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Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

Autor: Biswas, S, Troy, H, Leek, R, Chung, YL, Li, JL, Raval, RR, Turley, H, Gatter, K, Pezzella, F, Griffiths, JR, Stubbs, M, Harris, AL

In cultured clear-cell renal carcinoma (CCRCC) 786-0 cells transfected with HIF1alpha (HIF-1+), HIF-2alpha (HIF-2+), or empty vector (EV), no significant differences were observed in the growth rates in vitro, but when grown in vivo as xenografts HIF

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https://ora.ox.ac.uk/objects/uuid:fffdf176-3d28-4c9d-9539-a1da73da3540

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Automated uro-oncology data collection: the Cancer Research Uro-Oncology Database

Autor: Charlesworth, PJ, Kilbey, N, Taylor, M, Leek, R, Cranston, D, Turner, G, Crew, J, Harris, A, Protheroe, A

OBJECTIVE: To develop a relational database (Cancer Research Uro-Oncology Database, CRUD) to enable automatic data collection on all urological malignancies within our region, as there is increasing emphasis on good data collection for surgical patie

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