Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Leehyeon Kim"'
Autor:
Do Hoon Kwon, Ok Hyun Park, Leehyeon Kim, Yang Ouk Jung, Yeonkyoung Park, Hyeongseop Jeong, Jaekyung Hyun, Yoon Ki Kim, Hyun Kyu Song
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The autophagy adapter p62/SQSTM1 plays a key role in selective autophagy and also recognizes N-end rule substrates. Here the authors provide molecular insights into p62 N-end rule substrate recognition by solving the structures of the p62 ZZ-domain i
Externí odkaz:
https://doaj.org/article/fb9f90376e734fe7b3892591b7d6608f
Publikováno v:
Biochemical and Biophysical Research Communications. 582:86-92
The cellular glucose level has to be tightly regulated by a variety of cellular processes. One of them is the degradation of gluconeogenic enzymes such as Fbp1, Icl1, Mdh2, and Pck1 by GID (glucose-induced degradation deficient) E3 ubiquitin ligase.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79af5d1b009cd3ef96453985e257795d
https://doi.org/10.1016/j.bbrc.2021.10.007
https://doi.org/10.1016/j.bbrc.2021.10.007
Autor:
Kwon Jeong, Leehyeon Kim, Hyun Jung Hwang, Joori Park, Oliver Mühlemann, Simone C. Rufener, Hyun Kyu Song, Yeonkyoung Park, Yoon Ki Kim
Publikováno v:
Nucleic Acids Research
Park, Yeonkyoung; Park, Joori; Hwang, Hyun Jung; Kim, Leehyeon; Jeong, Kwon; Song, Hyun Kyu; Rufener, Simone C.; Mühlemann, Oliver; Kim, Yoon Ki (2021). Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction. Nucleic acids research, 49(14), pp. 8261-8276. Oxford University Press 10.1093/nar/gkab579
Park, Yeonkyoung; Park, Joori; Hwang, Hyun Jung; Kim, Leehyeon; Jeong, Kwon; Song, Hyun Kyu; Rufener, Simone C.; Mühlemann, Oliver; Kim, Yoon Ki (2021). Translation mediated by the nuclear cap-binding complex is confined to the perinuclear region via a CTIF–DDX19B interaction. Nucleic acids research, 49(14), pp. 8261-8276. Oxford University Press 10.1093/nar/gkab579
Newly synthesized mRNA is translated during its export through the nuclear pore complex, when its 5′-cap structure is still bound by the nuclear cap-binding complex (CBC), a heterodimer of cap-binding protein (CBP) 80 and CBP20. Despite its critica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305a87f55891849e07a51edab2029f25
http://europepmc.org/articles/PMC8373075
http://europepmc.org/articles/PMC8373075
Autor:
Leehyeon Kim, Chih-Cheng Lin, Ting-Jhen Lin, Yan-Cih Cao, Min-Chun Chen, Mei-Yi Chou, Wen-Hsuan Lin, Minki Kim, Jian-Li Wu, Ming-Che Shih, Hyun Kyu Song, Meng-Chiao Ho
The submergence response in higher plants is highly dependent on the protein stability of group VII ethylene response factors, which are primarily degraded through the oxygen-dependent Cys-Arg branch of the N-degron pathway of targeted proteolysis. K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cc7559ad5d93b0df814806ccce93ba8
https://doi.org/10.1101/2022.08.19.504472
https://doi.org/10.1101/2022.08.19.504472
Autor:
Leehyeon Kim, Byung‐Gil Lee, Minki Kim, Min Kyung Kim, Do Hoon Kwon, Hyunmin Kim, Heike Brötz‐Oesterhelt, Soung‐Hun Roh, Hyun Kyu Song
Publikováno v:
EMBO J
The ClpP serine peptidase is a tetradecameric degradation molecular machine involved in many physiological processes. It becomes a competent ATP-dependent protease when coupled with Clp-ATPases. Small chemical compounds, acyldepsipeptides (ADEPs), ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d98396bf8d9db7f2361f6c66e1e3ca6
https://europepmc.org/articles/PMC9251834/
https://europepmc.org/articles/PMC9251834/
Publikováno v:
J Biol Chem
The N-degron pathway, formerly the N-end rule pathway, is a protein degradation process that determines the half-life of proteins based on their N-terminal residues. In contrast to the well-established in vivo studies over decades, in vitro studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0de6e4b9e85f3c5ed39d4847b5fb12e7
https://doi.org/10.1074/jbc.ra119.010912
https://doi.org/10.1074/jbc.ra119.010912
Publikováno v:
Proc Natl Acad Sci U S A
N-degron pathways are proteolytic systems that recognize proteins bearing N-terminal (Nt) degradation signals (degrons) called N-degrons. Our previous work identified Gid4 as a recognition component (N-recognin) of the Saccharomyces cerevisiae proteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f02e9e0804cde64ed8b3d0ea3aa027c
https://doi.org/10.1073/pnas.2115430118
https://doi.org/10.1073/pnas.2115430118
Autor:
Hyun Kyu Song, Heike Brötz-Oesterhelt, Hyun-Min Kim, Do Hoon Kwon, Min Kyung Kim, Soung Hun Roh, Leehyeon Kim, Byung-Gil Lee
The ClpP serine peptidase is a tetradecameric degradation machine involved in many physiological processes. It becomes a competent ATP-dependent protease with Clp-ATPases. Small chemical compounds, acyldepsipeptides (ADEPs), are known to cause dysreg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d693be3b8c8a8134ac46284ca8deed3f
https://doi.org/10.1101/2021.09.20.461017
https://doi.org/10.1101/2021.09.20.461017
Autor:
Se Hwan Jang, Zee Yong Park, Do Hoon Kwon, Jiwon Heo, Hyun Kyu Song, Leehyeon Kim, Jin Seok Shin
Publikováno v:
Protein Sci
The N-degron pathway determines the half-life of proteins in both prokaryotes and eukaryotes by precisely recognizing the N-terminal residue (N-degron) of substrates. ClpS proteins from bacteria bind to substrates containing hydrophobic N-degrons (Le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d0a343c2c94dd0777ca83b2f29b5d
https://pubmed.ncbi.nlm.nih.gov/33368743
https://pubmed.ncbi.nlm.nih.gov/33368743